Canid genomics: Mapping genes for behavior in the silver fox

Spady, Tyrone C.; Ostrander, Elaine A.

doi:10.1101/gr.6055807

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…The similarity of the fox genome to that of the dog (Kukekova et al . ; Spady & Ostrander ) allowed Kukekova et al . () to adapt dog microsatellite markers to the fox to create a meiotic linkage map.…”

Section: Molecular Approaches To Behavioral Genetics In the Dogmentioning

confidence: 99%

“…Silver foxes (a morph of the Red fox, Vulpes vulpes) have been bred for over 50 years at the Institute for Cytology and Genetics (ICG) in Novosibirsk, Russia. Starting in 1959, Dmitry Belyaev selectively bred foxes for tame behavior toward humans (for reviews see Kukekova et al 2008a,b;Spady & Ostrander 2007;Trut 1999). Within two decades it was clear his experiment was a success, and now the ICG possess a strain of foxes that show high levels of sociable behavior toward humans, as well as a strain that is highly aggressive toward people.…”

Section: Advantages Of a Canid Model For Behavioral Geneticsmentioning

confidence: 99%

“…The similarity of the fox genome to that of the dog (Kukekova et al 2007;Spady & Ostrander 2007) allowed Kukekova et al (2007) to adapt dog microsatellite markers to the fox to create a meiotic linkage map. Kukekova et al (2008a,b) then linked the markers to objectively measured behaviors from the tame, aggressive and unselected strains of Belyaev foxes as well as tame × aggressive F1 hybrids and a backcross of the F1s to tame foxes.…”

Section: Foxesmentioning

confidence: 99%

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The canid genome: behavioral geneticists' best friend?

Hall

Wynne

2012

Genes Brain and Behavior

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We review a range of studies on the genetic contribution to behavior in canid species. We begin by identifying factors that make canids a promising model in behavioral genetics and proceed to review research over the last decade that has used canids to identify genetic contributions to behavior. We first review studies that have selectively bred dogs to identify genetic contributions to behavior and then review studies that estimate heritability from populations of nonlaboratory bred dogs. We subsequently review studies that used molecular genetics to identify gene-behavior associations and note associations that have been uncovered. We then note challenges in canid behavioral genetics research that require further consideration. We finish by suggesting alternative phenotyping methods and identify areas in which canids may have as yet unexploited advantages, such as in gene-environment interaction studies where genetic factors are found to moderate the effects of environmental variables.

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Section: Molecular Approaches To Behavioral Genetics In the Dogmentioning

confidence: 99%

Section: Advantages Of a Canid Model For Behavioral Geneticsmentioning

confidence: 99%

Section: Foxesmentioning

confidence: 99%

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The canid genome: behavioral geneticists' best friend?

Hall

Wynne

2012

Genes Brain and Behavior

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“…Kukekova et al ( 2004 ) reported, that over 60 % of tested canine-derived microsatellite markers robustly amplified fox DNA were polymorphic in foxes and were thus applicable for genotyping fox pedigrees. Because of the close phylogenetic relationship between the dog and the red fox, genomic resources developed previously in the dog have proven useful in the construction of the fox meiotic linkage map (Spady and Ostrander 2007 ). The first meiotic linkage map of the silver fox (which is a colour variant of the red fox) has been published by Kukekova et al ( 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox (Vulpes vulpes L.)

et al. 2014

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Polymorphism of 30 canine-derived microsatellites was studied in a group of 200 red foxes kept on 2 Polish farms. 22 out of 30 microsatellites were selected to study association between marker genotypes and body weight (BW), body length (BL), body circumference (BC), tail length (TL), ear height (EH), length of the right front limb (FRLL), length of the right rear limb (RRLL), length of the right front foot (FRFL) and length of the right rear foot (RRFL). A total of 112 alleles and 243 genotypes were found at 22 autosomal microsatellite loci. Three monomorphic loci deemed as uninformative were excluded from the study. The association between marker genotypes and the studied traits was analysed using general linear model (GLM) procedure and least squares means (LSM). Linkage disequilibrium (LD) was estimated to assess non-random association between microsatellite loci. Out of 19 microsatellites studied four markers showed no association with the studied traits, three markers had a significant effect on one trait, and another three markers had significant effect on two traits. Among ten microsatellites with significant effect on four economically important traits (BW, BL, BC, TL) four were associated with two characters: marker FH2613 with BW and BC, marker FH2097withBL and BC, marker ZUBECA6 with BW and BC, whereas marker REN75M10 was associated with BL and TL. The strongest LD (r2 ranged from 0.15 to 0.33) was estimated between nine loci with significant effect on economically important traits (BW, BL, BC, TL).

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“…The family Canidae is consisted of 36 species, including dog (Canis familiaris) and three fur-bearing animals: red fox (Vulpes vulpes), arctic fox (Alopex lagopus) and Chinese raccoon dog (Nyctereutes procyonoides procyonoides). Due to extensive variability of behaviour traits observed in different dog breeds, the dog and silver fox are considered as a useful models to study genetic background of it (OSTRANDER and WAYNE, 2005;SPADY and OSTRANDER, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic mapping and STR polymorphism of two candidate genes (<i>DRD2</i> and <i>HTR1D</i>) for behaviour traits in four canids (short communication)

Szczerbal¹,

Nowacka‐Woszuk²,

Racka³

et al. 2007

Arch. Anim. Breed.

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Abstract. The dopamine D2 receptor (DRD2) and serotonin receptors 1D (HTR1D) are candidate genes for behavioural traits. In the present study, we show chromosomal location and polymorphism of these genes in four species from the family Canidae: dog (CFA), red fox (VVU), arctic fox (ALA) and the Chinese raccoon dog (NPP). Using fluorescence in situ hybridisation (FISH) the DRD2 gene was localized in the following chromosomes: CFA5q12-13, VVU12q21, ALA10q14 and NPP3q14 and the HTR1D gene was mapped to: CFA2q25, VVU2q22, ALA8q25 and NPP10q25. A microsatellite marker (TG)n in intron 3 of the DRD2 gene and (CA)n motif located in a 3’-flanking region of the HTR1D gene were polymorphic in all studied species. The obtained results can be helpful in further studies on effects of polymorphisms of these genes on behaviour traits in canids.

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Canid genomics: Mapping genes for behavior in the silver fox

Cited by 7 publications

References 36 publications

The canid genome: behavioral geneticists' best friend?

The canid genome: behavioral geneticists' best friend?

Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox (Vulpes vulpes L.)

Cytogenetic mapping and STR polymorphism of two candidate genes (<i>DRD2</i> and <i>HTR1D</i>) for behaviour traits in four canids (short communication)

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Canid genomics: Mapping genes for behavior in the silver fox

Cited by 7 publications

References 36 publications

The canid genome: behavioral geneticists' best friend?

The canid genome: behavioral geneticists' best friend?

Microsatellite polymorphism and its association with body weight and selected morphometrics of farm red fox (Vulpes vulpes L.)

Cytogenetic mapping and STR polymorphism of two candidate genes (&lt;i&gt;DRD2&lt;/i&gt; and &lt;i&gt;HTR1D&lt;/i&gt;) for behaviour traits in four canids (short communication)

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Cytogenetic mapping and STR polymorphism of two candidate genes (<i>DRD2</i> and <i>HTR1D</i>) for behaviour traits in four canids (short communication)