Candidose Oral

Mangueira, Dayane Franco Barros

doi:10.4034/rbcs.2010.14.02.09

Cited by 3 publications

(4 citation statements)

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“…According to human studies, C. albicans is the most common strain in both healthy the mucosa and oral candidiasis, because of its high pathogenicity and ability to adhere to the mucosa [ 3 ]. In addition, C. tropicalis , C. krusei and C. glabrata strains have been reported to play an important role in oral candidiasis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

et al. 2021

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The effectiveness of antifungal agents may be insufficient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal effect of thymoquinone against Candida albicans , Candida tropicalis , Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candida albicans ATCC 10,231, C. tropicalis ATCC 750, C.krusei ATCC 6258 and C. glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and ΣFIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical significance was set at p < 0.05. A statistically significant difference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin ( p < 0.05). MIC values for thymoquinone were determined as 15 μg/mL for C. albicans , C. tropicalis and C. krusei while it was 30 μg/mL for C. glabrata . Moreover, MIC for nystatin was found as 1.875 μg/mL for C. albicans , C. tropicalis and C. krusei , whereas it was 7.5 μg/mL in C. glabrata. Interaction assays and ΣFIC index value revealed that, TQ and nystatin have a synergistic effect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic effect when combined with nystatin.

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Section: Discussionmentioning

confidence: 99%

“…Oral candidiasis is an opportunistic infection affecting the palatal and jugal mucosal regions of the oral mucosa [ 3 ]. In addition, the use of nystatin, miconazole, fluconazole and ketoconazole are often recommended for the treatment of this disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

et al. 2021

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“…A mais comum delas é a candidíase oral, que se caracteriza como uma infecção produzida pelos microorganismos Candida sp, sendo a espécie albicans, a que mais acomete o meio bucal. Trata-se de uma infecção oportunista, visto que este fungo é um habitante natural do sítio anatômico oral, porém torna-se patológico principalmente em indivíduos imunossuprimidos (Mangueira et al, 2010;Siqueir et al, 2014). A candidíase pode se apresentar nas formas clínicas pseudomembranosa, eritematosa, crônica hiperplásica e queilite angular, podendo ocorrer mais.…”

Section: Antifúngicosunclassified

“…A candidíase pode se apresentar nas formas clínicas pseudomembranosa, eritematosa, crônica hiperplásica e queilite angular, podendo ocorrer mais. De um tipo no mesmo indivíduo ao mesmo tempo (Mangueira et al 2010;Vieira et al 2012). Tendo em vista o número de casos, e a importância do tratamento, está esquematizada na Tabela 7, a terapêutica para o tratamento dessas afecções.…”

Section: Antifúngicosunclassified

Protocolo farmacoterápico para as clínicas de atenção básica do curso de Odontologia

Manta

Silva

Nunes

et al. 2022

RSD

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Introdução: A importância da prescrição medicamentosa na odontologia está bem estabelecida na literatura, apesar de existirem poucas publicações referentes a protocolos farmacológicos. A grande quantidade de medicamentos ofertados ao cirurgião-dentista (CD), com suas respectivas indicações, posologias, contraindicações e efeitos adversos, somam inseguranças na hora da escolha do medicamento mais adequado. Objetivo: Elaboração de um protocolo farmacoterápico, usando como meio de obtenção deste protocolo um código de resposta rápida (QR CODE), acessados através de dispositivos eletrônicos moveis. Método: avaliação da incidência de uso de medicamentos nas áreas de cirurgia oral menor, endodontia (e urgências endodônticas), periodontia, odontopediatria e como profilaxia antibiótica. Usando como critérios de inclusão artigos, livros e bulários da ANVISA entre os anos de 2006 a 2021. Resultados: Elaboração de um protocolo medicamentoso de uso adulto e infantil baseado em odontologia segundo a literaturas recentes, usando como meio de divulgação e acesso um QR CODE, acessível através de dispositivos eletrônicos moveis. Conclusão: A utilização de um método digital/eletrônico, onde grande parcela de profissionais e estudantes de odontologia tem acesso, colabora para ambos na tomada de decisões no momento da prescrição de uma droga, assegurando o conhecimento dos fármacos mais frequentes na odontologia.

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Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study

Castro

Souza

Bezerra

et al. 2015

BMC Complement Altern Med

155

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BackgroundLimitations of antifungal agents used in the treatment of oral candidiasis, as the development of resistant strains, are known by the scientific community. In this context, the aim of this study was to evaluate the antifungal activity of thymol against Candida albicans, Candida tropicalis and Candida krusei strains and to determine its mode of action and synergistic effect when combined with the synthetic antifungal nystatin.MethodsThe minimum inhibitory concentration (MIC) was determined using a microdilution technique, and the minimum fungicidal concentration (MFC) was determined via subculture sowing. The mode of action of thymol was established by verifying fungal growth in the presence of sorbitol or ergosterol. The fractional inhibitory concentration index (FIC) was determined using the checkerboard method.ResultsThymol presented an antifungal effect, with MICs of 39 μg/mL for C. albicans and C. krusei and 78 μg/mL for C. tropicalis. The results of the antifungal test remained unchanged in the presence of sorbitol; however, the MIC value of thymol against C. albicans increased eight times (from 39.0 to 312.5 μg/mL) in presence of exogenous ergosterol. The combination of thymol and nystatin reduced the MIC values of both products by 87.4 %, generating an FIC index of 0.25.ConclusionsThymol was found to have a fungicidal effect on Candida species and a synergistic effect when combined with nystatin.

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Candidose Oral

Cited by 3 publications

References 0 publications

Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

Protocolo farmacoterápico para as clínicas de atenção básica do curso de Odontologia

Antifungal activity and mode of action of thymol and its synergism with nystatin against Candida species involved with infections in the oral cavity: an in vitro study

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