Candidone, a flavanone from Tephrosia candida

Roy, Manisha; Mitra, Santi R.; Bhattacharyya, Anjan; Adityachaudhury, N.

doi:10.1016/0031-9422(86)80039-5

Cited by 22 publications

(12 citation statements)

References 8 publications

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“…[a] D À33°(CHCl 3 , c 1.0)} (Garcez et al, 1988). This compound exhibited closely comparable spectral data (UV, 1 H NMR) to published values (Roy et al, 1986). (C-2), 88.6 (C-6), 110.2 (C-8), 122.4 (C-2@), 125.8 (C-2', C-6'), 128.2 (C-4'), 128.5 (C-3', C-5'), 131.3 (C-3@), 139.2 (C-1'), 160.6 (C-5), 161.0 (C-7*), 163.2 (C-9*), 190.0 (C-4).…”

Section: Plantsupporting

confidence: 69%

Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis

Blatt

Chávez

Chai

et al. 2002

Phytotherapy Research

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Activity-guided fractionation of a chloroform-soluble extract of Lonchocarpus aff. fluvialis stem bark using a human epidermoid (KB) tumour cell line as a monitor afforded five rotenoids, one pterocarpan, one chalcone, three flavanones, one flavone and one triterpenoid. All of the compounds isolated proved to be of previously known structure. Among them, the rotenoids (-)-sumatrol and (+/-)-villosinol, the dibenzoylmethane derivative (+)-3,4-methylenedioxy-2'-methoxy-[2",3":4',3']-furanodibenzoylmethane, and the flavanones (-)-isoglabrachromene and (-)-candidone have been shown to exhibit significant cytotoxic activity against human cancer cells for the first time. This is the first report of the chemical constituents of this species, and the profile of compounds obtained was in accordance with the established chemosystematic patterns of species in the tribe Tephrosieae (Leguminosae, Papilionoideae).

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Section: Plantsupporting

confidence: 69%

Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis

Blatt

Chávez

Chai

et al. 2002

Phytotherapy Research

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“…C-L008 is an analogue of Ovalichalcone, a compound isolated from the seeds of Milletia ovalifolia known to have anti-bacterial and anti-fungal activities. [30, 31] C-P013 is an analogue of Amromadendrene, an oil extract of Melaleuca alternifolia with anti-inflammatory properties. [32, 33] C-A005 belongs to triucallane-type triterpenes, a class of compounds that have been widely used as a gastroprotective, hypocholoesterolaemic, and anti-inflammatories.…”

Section: Resultsmentioning

confidence: 99%

A sandwiched microarray platform for benchtop cell-based high throughput screening

Wu¹,

Wheeldon²,

Guo³

et al. 2011

Biomaterials

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The emergence of combinatorial chemistries and the increased discovery of natural compounds have led to the production of expansive libraries of drug candidates and vast numbers of compounds with potentially interesting biological activities. Despite broad interest in high throughput screening (HTS) across varied fields of biological research, there has not been an increase in accessible HTS technologies. Here, we present a simple microarray sandwich system suitable for screening chemical libraries in cell-based assays at the benchtop. The microarray platform delivers chemical compounds to isolated cell cultures by ‘sandwiching’ chemical-laden arrayed posts with cell-seeded microwells. In this way, an array of sealed cell-based assays was generated without cross-contamination between neighboring assays. After chemical exposure, cell viability was analyzed by fluorescence detection of cell viability indicator assays on a per microwell basis in a standard microarray scanner. We demonstrate the efficacy of the system by generating four hits from toxicology screens towards MCF-7 human breast cancer cells. Three of the hits were identified in a combinatorial screen of a library of natural compounds in combination with verapamil, a P-glycoprotein inhibitor. A fourth hit, 9-methoxy-camptothecin, was identified by screening the natural compound library in the absence of verapamil. The method developed here miniaturizes existing HTS systems and enables the screening of a wide array of individual or combinatorial libraries in a reproducible and scalable manner. We anticipate broad application of such a system as it is amenable to combinatorial drug screening in a simple, robust and portable platform.

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“…Both compounds showed distinct bathochromic shifts of 25 nm (compared to the spectrum in MeOH) which favours the position of the prenyl substituent at C-8 rather than at C-6(15). The prenylated pinocembrin derivative has been isolated previously from species of the Fabaceae such as Tephrosia candida (16) or Piscidia erythrina (17), whereas 8-C-eriodictyol was recently reported from Wyethia glabra (Asteraceae) (18). A further flavanone 10 isolated from the resin of E. stenophylla showed the molecular ion at mlz 272 in the mass spectrum which indicated the presence of three hydroxyl substituents in the molecule (19).…”

Section: Resultsmentioning

confidence: 99%

Epicuticular Flavonoids fromEncelia(Asteraceae)

Proksch¹,

Politt²,

Wollenweber³

et al. 1988

Planta Med

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Most of the species of the North American genus Encelia have been analysed for lipophilic flavonoids present as constituents of the resins secreted on the surfaces of leaves and stems. Thirty different flavonoids have been isolated and identified. The compounds included several new and unusual flavanones mainly based on pinocembrmn, naringenin, and eriodictyol. The structural elucidation of these compounds by spectroscopic means is described. The flavonoid patterns are briefly discussed with regard to the systematics of Encelia.

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Candidone, a flavanone from Tephrosia candida

Cited by 22 publications

References 8 publications

Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis

Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis

A sandwiched microarray platform for benchtop cell-based high throughput screening

Epicuticular Flavonoids fromEncelia(Asteraceae)

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