Candidiasis in Simians

Wikse, Steven E.; Fox, James G.; Kovatch, Robert M.

doi:10.21236/ad0860429

Cited by 6 publications

(9 citation statements)

References 1 publication

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“…Disease Anorexia, dysphagia, open-mouth breathing due to ulcers of the hard palate, dehydration, and diarrhea are associated with candidiasis (Kaufmann and Quist, 1969b;Wikse et al, 1970;Weller, 1994). Onychomycosis, with shortening, erosion, and deformation of the nails, and balanitis have also been associated with candidiasis (Kerber et al, 1968;Wikse et al, 1970).…”

Section: Candidiasismentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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Section: Candidiasismentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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“…In fact, numerous studies have shown that nonhuman primates experience Candida species infections from similar predisposing factors as humans, including immunodeficiency [33][34][35]. Furthermore, rhesus macaques have been shown to have vaginal-associated Langerhans' cells, macrophages, and CD4 ϩ and CD8 ϩ T cells similar to those of humans [36,37].…”

mentioning

confidence: 99%

Differential Susceptibility of Two Species of Macaques to Experimental Vaginal Candidiasis

1999

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Vulvovaginal candidiasis (VVC) caused by Candida albicans is a significant problem in women of childbearing age. Unfortunately, protective host defense mechanisms against VVC are poorly understood. Although rodent models of experimental vaginal candidiasis have been useful, several differences from humans limit the correlation of experimental data. The purpose of the present study was to examine two species of macaques as an alternative model of experimental vaginitis. Screening of pig-tailed and rhesus macaques demonstrated that each had mucosal Candida colonization and prior immune sensitization to C. albicans. Vaginal-associated immunity (cytokines, antibodies, and innate resistance) was also detected in cervicovaginal lavage fluid from both species. Nevertheless, intravaginal inoculation of C. albicans into both species, either untreated or under estrogen-treated conditions, resulted in vaginal infection in rhesus, but not pig-tailed, macaques. Several estrogen-dependent changes in the rhesus immune status coincided with susceptibility to infection. Taken together, these results suggest that pig-tailed and rhesus macaques may be useful in studying pathogenesis and immunity associated with C. albicans vaginitis.

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“…Candida albicans was isolated from tongue, liver, lung, and intestine. As suggested by Wikse et al [12], the pre valence of candidiasis in nonhuman primates probably exceeds that indi cated by published reports and it should be considered in the differential diagnosis of chronic upper respiratory and/or enteric disease.…”

Section: Pathologymentioning

confidence: 84%

“…In contrast, reports of lesions in nonhuman primates relatable to infection with Candida spp. are few and most are associated with other disease processes or anti bacterial prophylaxis [10,12]. The opportunistic nature of Candida spp.…”

Section: Introductionmentioning

confidence: 99%