Candidemias: análisis multicéntrico en 16 hospitales andaluces

Rodríguez-Hernández, María Jesús; Pipaón, Maite Ruiz-Pérez de; Márquez‐Solero, Manuel; Martín-Rico, Patricia; Castón-Osorio, Juan José; Guerrero-Sánchez, Francisca; Vidal-Verdú, Elisa; García-Figueras, C.; Jiménez, Alfonso del Arco; Rodríguez-Baño, Jesús; Martín-Mazuelos, Estrella; Cisneros, José Miguel

doi:10.1016/j.eimc.2010.12.003

Cited by 33 publications

(12 citation statements)

References 19 publications

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“…The OR for mortality of PBS as a continuous variable (~1.4 combined with CCI or CDS) is comparable to those reported in other studies involving bloodstream infections . In addition, two studies of patients with CBI have used PBS≥2 as a cut‐off value to assess the risk of mortality and calculated ORs for mortality (4.10 and 6.21) are comparable to the ORs obtained in our cohort.…”

Section: Discussionsupporting

confidence: 88%

“…Creatinine levels were included in the models assessing the CDS, as this score does not include any variable recording information on chronic or acute kidney disease. The CCI, CDS and PBS were included as continuous or dichotomised variables in different models (≤2 and ≥3 were used as cut‐off CCI values, ≤3 and ≥4 were used for the CDS and ≤1 and ≥2 were used for the PBS). Thus, four different models were tested with the following comorbidity and severity measures: CCI and PBS as continuous variables (model 1), CCI and PBS as categorical variables (model 2), CDS and PBS as continuous variables (model 3) and CDS and PBS as categorical variables (model 4).…”

Section: Methodsmentioning

confidence: 99%

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The Pitt Bacteremia Score, Charlson Comorbidity Index and Chronic Disease Score are useful tools for the prediction of mortality in patients with Candida bloodstream infection

Vaquero-Herrero

Ragozzino

Castaño-Romero

et al. 2017

Mycoses

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Candida bloodstream infection (CBI) is associated with high mortality. The aim of this study was to compare the utility of the combined use of the Pitt Bacteremia Score (PBS) and Charlson Comorbidity Index (CCI) or Chronic Disease Score (CDS) to predict mortality among patients with CBI. Thereby, all consecutive patients with CBI at our institution between 2010 and 2014 were included. The PBS was used to evaluate CBI severity and the CCI and CDS were used to assess comorbidities of patients with CBI. Logistic regression analysis was used to estimate odds ratios for 30-day mortality in models including the PBS and CCI or CDS. A total of 189 CBI episodes were identified. Logistic regression models including the PBS and either CCI or CDS showed that the combined use of a comorbidity score and a severity score significantly predicted 30-day mortality. The performance of the different models was similar. Aggregated scores of comorbidity (CCI and CDS) and disease severity (PBS) are useful for the prediction of 30-day mortality risk in patients with CBI. Their use may facilitate the analysis of risk factors for poorer outcome and the development of an index for CBI mortality.

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

The Pitt Bacteremia Score, Charlson Comorbidity Index and Chronic Disease Score are useful tools for the prediction of mortality in patients with Candida bloodstream infection

Vaquero-Herrero

Ragozzino

Castaño-Romero

et al. 2017

Mycoses

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“…La mortalidad global de nuestra casuística fue comparable a otros estudios semejantes 3,9,11,38,[63][64][65] , es mayor a la que se debería tener 6,10,15,28,34,60 y no ha disminuido. Lo más importante para mejorar la evolución de los pacientes es llegar a un diagnóstico temprano.…”

Section: Artículo Originalunclassified

Epidemiología, especies, resistencia antifúngica y evolución de las candidemias en un hospital universitario de Buenos Aires, Argentina, durante 16 años

Tiraboschi

Pozzi

Farias

et al. 2017

Rev. chil. infectol.

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“…La sensibilidad frente al fluconazol, señalada por Almirante como muy alta (6) y por Rodríguez-Hernández en ambiente hospitalario cercana al 89% (8) , en nuestro estudio encontramos que 7 de 11 cepas fueron sensibles.…”

Section: Discussionunclassified

Aislamiento de Candida albicans de hisopado nasal y faríngeo en alumnos de secundaria

et al. 2014

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ResumenIntroducción: Candida sp puede encontrarse como comensal en equilibrio en la cavidad bucal humana; pero, en la población pediátrica y adolescente con un sistema inmune inmaduro las condiciones de la levadura se tornarían favorables para su patogenia. Objetivo: Determinar la presencia de Candida albicans en secreción faríngea y nasal en alumnos de educación secundaria. Diseño: Estudio descriptivo transversal. Lugar: Instituto de Medicina Tropical, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Alumnos del 4° (52) y 5° (50) años de secundaria. Intervenciones: En octubre del 2007, las muestras nasales y faríngeas de 102 estudiantes de 14 a 17 años fueron colectadas en medios de transporte y luego cultivadas en los laboratorios del Instituto de Medicina Tropical, en agar sabouraud y CHROMOagar Candida. Se identificó las colonias sospechosas de Candida sp mediante el estudio de clamiodoconidias, tubo germinativo y pruebas metabólicas. Principales medidas de resultados: Identificación de levaduras de Candida sp. Resultados: Se aisló levaduras del género Candida en 11 de los escolares (10,8%). El 36,4% de las levaduras presentó resistencia moderada al antimicótico fluconazol. Conclusiones: Es recomendable continuar con estudios de vigilancia epidemiológica sobre las levaduras de importancia médica en portadores nasofaríngeos, con el fin estar preparados ante eventuales cuadros infecciosos. Palabras clave: Candida albicans, escolares, fluconazol. Abstract Objective: To determine the presence of Candida albicans in throat and nasal secretion in high school students. Design: Crosssectional study. Setting: Institute of Tropical Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: High school students from San Juan Macias School in Santa Anita, Lima, Peru. Interventions: Nasal and throat samples were collected from 102 14-17 year-old students. Samples were grown on sabouraud agar and Candida CHROMOagar and identified by chlamydospores study and metabolic tests. Main outcome measures: Identification of C. albicans yeast. Results: Candida yeast was isolated from 11 students (10.8%). A significant percentage of yeast (36.4%) developed moderate resistance to fluconazole. Conclusions: Continuous surveillance of medically important yeasts in nasopharyngeal carriers is suggested in order to be prepared for eventual infectious conditions.

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Candidemias: análisis multicéntrico en 16 hospitales andaluces

Cited by 33 publications

References 19 publications

The Pitt Bacteremia Score, Charlson Comorbidity Index and Chronic Disease Score are useful tools for the prediction of mortality in patients with Candida bloodstream infection

The Pitt Bacteremia Score, Charlson Comorbidity Index and Chronic Disease Score are useful tools for the prediction of mortality in patients with Candida bloodstream infection

Epidemiología, especies, resistencia antifúngica y evolución de las candidemias en un hospital universitario de Buenos Aires, Argentina, durante 16 años

Aislamiento de Candida albicans de hisopado nasal y faríngeo en alumnos de secundaria

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