“…Nevertheless, these are essential to support these patients' lives. (1,3,4) The strict execution techniques of these procedures and compliance with asepsis standards, in combination with appropriate staff numbers during care need to be taken into account in the practices at the neonatal intensive care units (NICU). (4) In that sense, the access to the VLBW infants' vascular network through central catheters and mechanic pulmonary ventilation, necessary for the preterm infants' life support, have been considered the main factors responsible for the occurrence of healthcare associated infections (HAI), with high rates at the NICU.…”
Objective: To correlative the invasive care procedures applied to very-low-birth-weight infants with the occurrence of neonatal sepsis. Methods: Retrospective, longitudinal cohort study undertaken through the investigation of secondary data between 2008 and 2012. The infants' characteristics were analyzed by means of the Mann-Whitney test (means) and the chi-square test to compare frequencies. All variables with significance of p<0.20 in the bivariate analysis were included in a logistic regression model. Results: The data demonstrated fourteen infants with an episode of late sepsis. The mean gestational age was 30 weeks. Female gender and cesarean birth were the most frequent. The birth weight and the use of an arterial umbilical catheter explained the occurrence of sepsis, offering an 8.5 times higher risk for the outcome. Conclusion: Vascular accesses need start insertion and handling techniques to improve the health indicators.
ResumoObjetivo: Correlacionar os procedimentos assistenciais invasivos realizados nos recém-nascidos de muito baixo peso com a ocorrência de sepse neonatal. Métodos: Estudo de coorte retrospectivo, longitudinal, por meio de pesquisa de dados secundários, durante os anos de 2008-2012. As características dos recém-nascidos foram analisadas pelo teste de Mann-Whitney (médias) e o teste do qui quadrado para comparação de frequências. Todas as variáveis com significância de p<0,20 na análise bivariada compuseram um modelo de regressão logística. Resultados: Os dados demonstraram quatorze recém-nascidos com episódio de sepse tardia. A idade gestacional média foi de trinta semanas. Gênero feminino e parto cesáreo foram os mais frequentes. O peso de nascimento e o uso do cateter umbilical arterial explicaram a ocorrência de sepse, tendo este oferecido 8,5 vezes maior risco para o desfecho. Conclusão: Acessos vasculares necessitam rigor nas técnicas de inserção e manuseio para a melhoria dos indicadores de saúde.
“…Nevertheless, these are essential to support these patients' lives. (1,3,4) The strict execution techniques of these procedures and compliance with asepsis standards, in combination with appropriate staff numbers during care need to be taken into account in the practices at the neonatal intensive care units (NICU). (4) In that sense, the access to the VLBW infants' vascular network through central catheters and mechanic pulmonary ventilation, necessary for the preterm infants' life support, have been considered the main factors responsible for the occurrence of healthcare associated infections (HAI), with high rates at the NICU.…”
Objective: To correlative the invasive care procedures applied to very-low-birth-weight infants with the occurrence of neonatal sepsis. Methods: Retrospective, longitudinal cohort study undertaken through the investigation of secondary data between 2008 and 2012. The infants' characteristics were analyzed by means of the Mann-Whitney test (means) and the chi-square test to compare frequencies. All variables with significance of p<0.20 in the bivariate analysis were included in a logistic regression model. Results: The data demonstrated fourteen infants with an episode of late sepsis. The mean gestational age was 30 weeks. Female gender and cesarean birth were the most frequent. The birth weight and the use of an arterial umbilical catheter explained the occurrence of sepsis, offering an 8.5 times higher risk for the outcome. Conclusion: Vascular accesses need start insertion and handling techniques to improve the health indicators.
ResumoObjetivo: Correlacionar os procedimentos assistenciais invasivos realizados nos recém-nascidos de muito baixo peso com a ocorrência de sepse neonatal. Métodos: Estudo de coorte retrospectivo, longitudinal, por meio de pesquisa de dados secundários, durante os anos de 2008-2012. As características dos recém-nascidos foram analisadas pelo teste de Mann-Whitney (médias) e o teste do qui quadrado para comparação de frequências. Todas as variáveis com significância de p<0,20 na análise bivariada compuseram um modelo de regressão logística. Resultados: Os dados demonstraram quatorze recém-nascidos com episódio de sepse tardia. A idade gestacional média foi de trinta semanas. Gênero feminino e parto cesáreo foram os mais frequentes. O peso de nascimento e o uso do cateter umbilical arterial explicaram a ocorrência de sepse, tendo este oferecido 8,5 vezes maior risco para o desfecho. Conclusão: Acessos vasculares necessitam rigor nas técnicas de inserção e manuseio para a melhoria dos indicadores de saúde.
“…The presence of C. krusei, which is the less common of the species, has been found in patients with hematologic neoplasms 8 . C. albicans is also the main etiological agent of candidiasis among neonatal ICU patients, although the infection epidemiology has been changing in the same way as for adult patients 23,24 . Among the non-C. albicans species, C. parapsilosis was previously found to be the most prevalent 25 .…”
Introduction: Infections caused by Candida spp are a major public health concern, due to the high mortality rate and the limited therapeutic arsenal. Objectives: To assess the prevalence of Candida spp infections and susceptibility to antifungal agents in a general hospital. Methods: Descriptive, cross-sectional study with collection of epidemiological and laboratory data on Candida spp cultures (2014 to 2019), at a large tertiary and philanthropic hospital in the city of Piracicaba, São Paulo state, Brazil. Results: A total of 63 episodes of Candida spp infection were eligible, being more prevalent in adults (88.9%) aged ≥ 70 years (41.3%), causing 40 deaths (63.5%). The C. albicans species represented 41.3% of the infections, with a mortality rate of 37.5%, while non-albicans species accounted for 58.7%, highlighting C. tropicalis (25.4%) and C. glabrata (23.8%), with a mortality rate of 27.5% for both species. Regarding the susceptibility profile, most were sensitive to echinocandins and azoles over the years. C. glabrata presented one case of resistance and dose-dependent sensitivity to caspofungin and micafungin and fluconazole, which was expected due to the decreased sensitivity to azoles, while the results for echinocandins were in agreement with previous studies showing increased resistance to this group of drugs. Conclusion: Given the high prevalence of hospital fungal infections and the associated mortality rate, determining the local epidemiological profile and susceptibility to drugs is an important strategy for guiding antifungal therapy.
“…Entretanto, estes são essenciais ao suporte à vida destes pacientes. (1,3,4) O rigor nas técnicas de execução destes procedimentos, a observância dos padrões de assepsia, aliados ao quantitativo adequado de profissionais na assistência, necessitam ser considerados nas práticas das unidades de terapia intensiva neonatal (UTIN). (4) Nesse sentido, o acesso à rede vascular do RNMBP através de cateteres centrais e a ventilação pulmonar mecânica, necessários para o suporte à vida dos pré-termo, vêm sendo considerados os principais responsáveis pela ocorrência de infecção relacionada à assistência à saúde (IRAS) com altas taxas nas UTIN.…”
Conflitos de interesse: não há conflitos de interesse a declarar.
ResumoObjetivo: Correlacionar os procedimentos assistenciais invasivos realizados nos recém-nascidos de muito baixo peso com a ocorrência de sepse neonatal. Métodos: Estudo de coorte retrospectivo, longitudinal, por meio de pesquisa de dados secundários, durante os anos de 2008-2012. As características dos recém-nascidos foram analisadas pelo teste de Mann-Whitney (médias) e o teste do qui quadrado para comparação de frequências. Todas as variáveis com significância de p<0,20 na análise bivariada compuseram um modelo de regressão logística. Resultados: Os dados demonstraram quatorze recém-nascidos com episódio de sepse tardia. A idade gestacional média foi de trinta semanas. Gênero feminino e parto cesáreo foram os mais frequentes. O peso de nascimento e o uso do cateter umbilical arterial explicaram a ocorrência de sepse, tendo este oferecido 8,5 vezes maior risco para o desfecho. Conclusão: Acessos vasculares necessitam rigor nas técnicas de inserção e manuseio para a melhoria dos indicadores de saúde.
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