Candidate Reference Measurement Procedures for Chloride, Potassium, Sodium, Calcium, Magnesium, and Lithium by Inductively Coupled Plasma (Isotope Dilution) Sector Field Mass Spectrometry (ICP-(ID) SFMS) in Serum

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…Yu et al 20 at NIST described a faster method, as compared to the tedious preparation required by TIMS, for the determination of Ca, K and Mg aer a simple dilution of serum samples. Comparable results were obtained by a separate group in Germany, 21 using the same technique for the simultaneous determination of a wider panel of elements (Ca, Cl, K, Li, Mg and Na) aer dilution of the serum samples with 4 mmol L À1 HNO 3 . Polyatomic interferences on the measurements of the 42 Ca : 44 Ca and 24 Mg : 26 Mg were substantially resolved at medium resolution, whereas residual interferences on the ratio 39 K : 41 K could not be eliminated completely at levels below 100 ng g À1 even using the high resolution mode.…”

A Simple and Accurate Measurement Procedure for Serum Chloride by Ion Chromatography and Bias Evaluation of Six Ion Selective Electrode Measurements in China

“…Comparisons between IDMS, coulometry, and IC methods for serum chloride measurement. Items IDMS [6] Coulometry (KCl) [12]…”

“…In another study of purity valuation of KCl by constant-current coulometric titration, bromide was titrated the same as chloride, and the mass fraction of chloride was over evaluated [5]. In Germany, inductively coupled plasma (isotope dilution) sector field mass spectrometry, ICP-(ID) SFMS, was established as a candidate reference measurement procedure for serum chloride [6]. For the IDMS method, the mean bias compared with the target values of the National Institute of Standards and Technology (NIST) certified reference materials was 0.85% for Cl -, which was a little higher than the ± 0.7% tolerable bias in the criterion of minimum specification from biological variation.…”

An improved reference method for serum cations measurement by ion chromatography

“…According to the list of reference measurement methods/procedures for electrolytes from Joint Committee for Traceability in Laboratory Medicine (JCLTM), the traditional reference methods were flame atomic emission spectrometry (FAES) for serum sodium and potassium and flame atomic absorption spectrometry (FAAS) for magnesium and calcium, respectively. The primary measurement procedures for sodium, potassium, magnesium, and calcium were inductively coupled plasma mass spectrometry (ICP‐MS) . However, those methods were normally very elaborate and time‐consuming and not suitable for every metrological task.…”

“…The primary measurement procedures for sodium, potassium, magnesium, and calcium were inductively coupled plasma mass spectrometry (ICP-MS). [9][10][11][12] However, those methods were normally very elaborate and timeconsuming and not suitable for every metrological task. Thienpont et al 13 first reported that the ion chromatography could be recommended as reference method for the determination of serum cations in clinical chemistry.…”