Candidate Medicinal Plant Species of Djiboutian Pharmacopeia for Testing Pharmacological Activities on Common Microbial Diseases

Abdoul-Latif, Fatouma Mohamed; Osman, Djaltou Aboubaker; Fourreh, Abdirahman Elmi; Abdallah, Alshaimaa Hassan; Merito, Ali; Hassan, Souad; Asfaw, Zemede; Kelbessa, Ensermu

doi:10.22159/ijpps.2016v8i10.5788

Cited by 3 publications

(3 citation statements)

References 65 publications

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“…Several studies conducted in recent decades revealed that extracts from the bark of A. seyal have antibacterial action [25,38,39], antimalarial effect [40], antimycobacterial effect, cyclooxygenase inhibition effect [41], molluscicidal activity [42], and anticancer activities [43,44]. Acacia gum has been established to possess several therapeutic actions, such as hypoglycemic, antidiabetic, antioxidant, immunomodulatory, and cytoprotective antiulcer, and has prebiotic properties [18,25].…”

Section: Medicinal Usesmentioning

confidence: 99%

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing Acacia seyal

et al. 2022

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Acacia seyal is an important source of gum Arabic. The availability, traditional, medicinal, pharmaceutical, nutritional, and cosmetic applications of gum acacia have pronounced its high economic value and attracted global attention. In addition to summarizing the inventions/patents applications related to gum A. seyal, the present review highlights recent updates regarding its phytoconstituents. Traditional, cosmetic, pharmaceutical, and medicinal uses with the possible mechanism of actions have been also reviewed. The patent search revealed the identification of 30 patents/patent applications of A. seyal. The first patent related to A. seyal was published in 1892, which was related to its use in the prophylaxis/treatment of kidney and bladder affections. The use of A. seyal to treat cancer and osteoporosis has also been patented. Some inventions provided compositions and formulations containing A. seyal or its ingredients for pharmaceutical and medical applications. The inventions related to agricultural applications, food industry, cosmetics, quality control of gum Arabic, and isolation of some chemical constituents (L-rhamnose and arabinose) from A. seyal have also been summarized. The identification of only 30 patents/patent applications from 1892 to 15 November 2021 indicates a steadily growing interest and encourages developing more inventions related to A. seyal. The authors recommend exploring these opportunities for the benefit of society.

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Section: Medicinal Usesmentioning

confidence: 99%

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing Acacia seyal

et al. 2022

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“…Many clinically useful prescription drugs have originated from traditional medicinal plants. Since there are many traditional medicinal plants widely used by society, it is worth subjecting these plants to investigate for the discovery of drugs with anticipation of obtaining new bioactive substances [1].…”

Section: Introductionmentioning

confidence: 99%

“…The method allows the growth of plant materials that otherwise would be difficult to grow in nature because of geographic, climatic, or seasonal restrictions. From the plant materials, the production of secondary metabolites can also be manipulated in vitro, which can lead to overproduction of compounds of interest, or the production of chemicals not originally found in native plants [1].…”

Section: Introductionmentioning

confidence: 99%

Bridelia Scandens Wild. A New Source for Podophyllotoxin Production in Vitro by Feeding Coniferyl Alcohol

Ravikumar

Krishna

Ajith

2020

Asian J Pharm Clin Res

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Objective: In the present study, a new method for the production of anticancerous compound podophyllotoxin (PTOX) was developed for Bridelia scandens Wild. by feeding coniferyl alcohol. Methods: The production of anticancerous compound PTOX through leaf explant derived calli of B. scandens. Murashige and Skoog (MS) medium fortified with 0.5 mg/l 6-Benzylaminopurine (BAP) and 0.5 mg/l 2,4-D (2,4-Dichlorophenoxyacetic acid) induced luxuriant mass of callus growth. Suspension culture was initiated by sterile MS media fortified with 0.1–1.0 mg/l BAP and 0.1–1.0 mg/l 2,4-D. and growth product was analyzed by the high-pressure liquid chromatography method. Results: Phytochemical analysis of the B. scandens leaf and leaf calli showed the presence of PTOX at the concentrations of 0.69 and 1.81, respectively. The callus cell suspension was established with the same callogenic media also it is augmented with 10–70 mg/l of coniferyl alcohol to elicit the biosynthesis of PTOX. Successive cultures of the calli suspension yielded stable production of PTOX of 3.91 mg/g dry cell weight at 50 mg/l coniferyl alcohol in the media. The biosynthesis of PTOX was ideal when plant cells were cultivated in the dark with an agitation speed of 100 rpm. Conclusion: The growth and production of PTOX were found to be better with glucose than with sucrose as the medium carbon source. The harvesting of the secondary metabolite from the in vitro grown leaf calli of B. scandens is a better way to stop the exploitation of medicinal plants.

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Evaluation of Antioxidant and Antibacterial Activities, Cytotoxicity of Acacia seyal Del Bark Extracts and Isolated Compounds

et al. 2020

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Water extract of Acacia seyal bark is used traditionally by the population in Djibouti for its anti-infectious activity. The evaluation of in vitro antibacterial, antioxidant activities and cytotoxicity as well as chemical characterization of Acacia seyal bark water and methanolic extracts were presented. The water extract has a toxicity against the MRC-5 cells at 256 μg/mL while the methanolic extract has a weak toxicity at the same concentration. The methanolic extract has a strong antioxidant activity with half maximal inhibitory concentration (IC50) of 150 ± 2.2 μg/mL using 1-diphenyl-2-picrylhydrazyl (DPPH) and IC50 of 27 ± 1.3 μg/mL using 2,2′-azino-bis 3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical methods. For ferric reducing/antioxidant power (FRAP) assay, the result is 45.74 ± 5.96 μg Vitamin C Equivalent (VCE)/g of dry weight (DW). The precipitation of tannins from methanol crude extract decreases the MIC from 64 µg/mL to 32 µg/mL against Staphylococcus aureus and Corynebacterium urealyticum. However, the antioxidant activity is higher before tannins precipitation than after (IC50 = 150 µg/mL for methanolic crude extract and 250 µg/mL after tannins precipitation determined by DPPH method). By matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis, the results showed that the condensed tannins consist of two types of catechin and gallocatechin-based oligomers. The fractionation led to the identification of three pure compounds: two flavanols catechin and epicatechin; one triterpene as lupeol; and a mixture of three steroids and one fatty acid: campesterol, stigmasterol, clionasterol, and oleamide.

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Candidate Medicinal Plant Species of Djiboutian Pharmacopeia for Testing Pharmacological Activities on Common Microbial Diseases

Cited by 3 publications

References 65 publications

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing Acacia seyal

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing Acacia seyal

Bridelia Scandens Wild. A New Source for Podophyllotoxin Production in Vitro by Feeding Coniferyl Alcohol

Evaluation of Antioxidant and Antibacterial Activities, Cytotoxicity of Acacia seyal Del Bark Extracts and Isolated Compounds

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