2015
DOI: 10.1073/pnas.1503292112
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Candidate ionotropic taste receptors in the Drosophila larva

Abstract: We examine in Drosophila a group of ∼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of the body wall that may be chemosensory. Expression was not observed in neurons of one taste organ, the terminal organ, although these neurons express many drivers of the Gr (Gustatory receptor) family. For most driver… Show more

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Cited by 84 publications
(78 citation statements)
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“…Some IRs are expressed in gustatory organs of adult or larval Drosophila [88, 97, 98], where investigations into their roles in taste perception have only recently been initiated. A large clade of IRs, the IR20a clade, consists of ~35 members that are more distantly related to the iGluRs.…”
Section: The Largest Families Of Chemoreceptorsmentioning
confidence: 99%
See 2 more Smart Citations
“…Some IRs are expressed in gustatory organs of adult or larval Drosophila [88, 97, 98], where investigations into their roles in taste perception have only recently been initiated. A large clade of IRs, the IR20a clade, consists of ~35 members that are more distantly related to the iGluRs.…”
Section: The Largest Families Of Chemoreceptorsmentioning
confidence: 99%
“…Neurons expressing these drivers project to taste centers in the CNS. Eleven drivers are expressed in the larva, mostly in single pairs of pharyngeal neurons [97]. …”
Section: The Largest Families Of Chemoreceptorsmentioning
confidence: 99%
See 1 more Smart Citation
“…As in the adult, members of Gr , ppk , and Ir families are expressed in larval taste neurons [19-21], defining sub-populations that are likely to have distinct functional roles. Gr and Ir genes that are expressed include some that are specific to larvae and others that are also in the adult [19,20]. Only a single sweet receptor, Gr43a, is expressed in the pharynx and brain [22].…”
Section: Introductionmentioning
confidence: 99%
“…We note that Drosophila larvae also use external digestion: they live in their food and engage in social digestion as they feed collectively (Gregg et al, 1990;Dombrovski et al, 2017) and actively regulate external digestion (Sakaguchi & Suzuki, 2013). Larvae express IR60b in their dorsal pharyngeal sensilla (Stewart et al, 2015).…”
Section: Introductionmentioning
confidence: 95%