2023
DOI: 10.1017/thg.2023.28
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Candidate Genes for Prediction of Efficacy and Safety of Statin Therapy in the Kazakh Population

Raikhan Y. Tuleutayeva,
Assem R. Makhatova,
Saule O. Rakhyzhanova
et al.

Abstract: The purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017−2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significa… Show more

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“…However, the issues of ADR-related drug safety of statins have also aroused great concerns. 8 ADR not only causes additional harm to patients, but also greatly interferes with clinical routine treatment. It is necessary to put on the agenda to systematically manage the use of statins in clinical practice.…”
Section: Introductionmentioning
confidence: 99%
“…However, the issues of ADR-related drug safety of statins have also aroused great concerns. 8 ADR not only causes additional harm to patients, but also greatly interferes with clinical routine treatment. It is necessary to put on the agenda to systematically manage the use of statins in clinical practice.…”
Section: Introductionmentioning
confidence: 99%