Candidate Genes Colocalized to Linkage Regions in Inflammatory Bowel Disease

Martin, Kathleen M.; Radlmayr, M.; Borchers, R.R.; Heinzlmann, M.; Folwaczny, C

doi:10.1159/000065592

Cited by 41 publications

(30 citation statements)

References 39 publications

(49 reference statements)

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“…On the basis of the search rules, a total of 83 articles were initially identified. Further application of our inclusion/exclusion criteria yielded 9 articles (Simmons et al, 2000;Martin et al, 2002;Dresner-Pollak et al, 2004;Naderi et al, 2008;Noble et al, 2008;Pluskiewicz et al, 2009;Bentley et al, 2011;Hughes et al, 2011;Pei et al, 2011), which included 1666 cases of ulcerative colitis (UC) cases, 1796 cases of CD, and 2647 controls; these 9 articles were involved in this meta-analysis. There were 6 studies on ApaI (Simmons et al, 2000;Naderi et al, 2008;Noble et al, 2008;Pluskiewicz et al, 2009;Hughes et al, 2011;Pei et al, 2011), 5 on BsmI (Dresner-Pollak et al, 2004;Naderi et al, 2008;Pluskiewicz et al, 2009;Hughes et al, 2011;Pei et al, 2011) and FokI (Simmons et al, 2000;Naderi et al, 2008;Hughes et al, 2011;Pei et al, 2011;Bentley et al, 2011), and 8 on TaqI (Simmons et al, 2000;Martin et al, 2002;Naderi et al, 2008;Noble et al, 2008;Pluskiewicz et al, 2009Hughes et al, 2011Pei et al, 2011;Bentley et al, 2011) …”

Section: Description Of Available Studiesmentioning

confidence: 99%

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Wang¹,

Wang²,

Hu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. Therefore, we conducted a meta-analysis to shed some light on this issue and explored the sources of the heterogeneity between studies. We identified six articles for ApaI (cases/controls: 1902/1468), eight for TaqI (3053/2145), and five each for BsmI (1512/1616) and FokI (2315/1676). Data were analyzed under the random-effects model, and heterogeneity was explored by subgroup analyses. Overall, except for TaqI in allelic comparison [odds ratio (OR) = 0.90, 95% confidence interval (CI): 0.83-0.98], ApaI, BsmI, and FokI polymorphisms showed no significant associations with IBD across different genetic models of inheritance. However, subgroup analyses indicated significance for the association of ApaI with Crohn's

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Section: Description Of Available Studiesmentioning

confidence: 99%

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Wang¹,

Wang²,

Hu³

et al. 2014

Genet. Mol. Res.

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“…41 IBD was considered as resulting from the imbalance between luminal bacterial flora and the immune system. 16 Regular use of nonsteroidal anti-inflammatory drugs (NSAID) could reduce the incidence of IBD and CRC. Thus, inflammation may be important in the development of IBD and CRC.…”

Section: Main Characteristics Of Included Studiesmentioning

confidence: 99%

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

Wang

Chen

et al. 2011

Eur J Hum Genet

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Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are common health problems worldwide. Tumor necrosis factor (TNF) is a type of cytokine that induces inflammation and inhibits tumorigenesis. Several studies have assessed the relationship between the polymorphism of TNF-a-308 G4A and the susceptibility to IBD and CRC; however, the results have been controversial. In addition, the hypothesis whether the increased risk of CRC in IBD patients could be partly ascribed to the polymorphism of TNF-a-308 G4A was unclear. Therefore, we conducted this meta-analysis to confirm these associations. Pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated on the basis of data from 14, 18, and 7 studies from a total of 27 studies for the associations between the polymorphism of TNF-a-308 G4A and ulcerative colitis, Crohn's disease (CD) and CRC. In Europeans, the AA genotype increased the risk of ulcerative colitis (UC) (OR, 2.041; 95% CI, 1.261-3.301) and CD (OR, 1.730; 95% CI, 1.168-2.564) significantly, without obvious heterogeneity and publication bias. Meanwhile, the GA genotype increased the risk of UC in Asians (OR, 2.360; 95% CI, 1.269-4.390) significantly. However, no significant association was observed for CRC in any ethnic population. The results of this meta-analysis suggested that the polymorphism of TNF-a-308 G4A participates in modifying the susceptibility to UC and CD in Europeans and Asians. The increased risk of CRC in IBD patients should be clarified as the combined effects of polymorphisms in TNF-a and other cytokines, and the interaction with environmental factors, in future studies.

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“…North-South gradients in rates of CD have been described in Europe and North America (12,15,16), although data concerning seasonal variations in CD relapse rates are conflicting (17)(18)(19). In addition, VDR gene polymorphisms correlate with susceptibility to CD and to ulcerative colitis (20,21). Associations between VDR signaling and IBD are also supported by animal models, where vitamin D sufficiency is associated with reduced frequency of onset and improved IBD symptoms in animals with established disease (22,23).…”

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confidence: 99%

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

Wang

Dabbas

Laperrière

et al. 2010

Journal of Biological Chemistry

352

284

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Importantly, this synergistic response was also seen in macrophages from a donor wild type for NOD2 but was absent in macrophages from patients with Crohn disease homozygous for non-functional NOD2 variants. These studies provide strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition, as Crohn's pathogenesis is associated with attenuated NOD2 or DEFB2/HBD2 function.

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Candidate Genes Colocalized to Linkage Regions in Inflammatory Bowel Disease

Cited by 41 publications

References 39 publications

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis

Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

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