Candidate gene analysis of osteochondrosis in <scp>S</scp>panish <scp>P</scp>urebred horses

Sevane, Natalia; Dunner, S.; Boado, A.; Cañón, Javier

doi:10.1111/age.12453

Cited by 9 publications

(10 citation statements)

References 47 publications

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“…There was limited evidence for consistent loci across the different horse breeds. A validation study with 144 Spanish Purebred horses using 48 intragenic genetic variants from previous reports showed suggestive associations for two SNPs on ECA 2 and 4 and a significant association for one SNP on ECA 2 .…”

Section: Linked and Associated Risk Loci For Osteochondrosismentioning

confidence: 84%

Genetic risk factors for osteochondrosis in various horse breeds

Naccache

Metzger

Distl

2018

Equine Veterinary Journal

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Osteochondrosis (OC) is an injury to cartilage canals with a following necrosis in the growth cartilage, from there it can develop to osteochondrosis dissecans (OCD). Due to its high impact in the equine industry, new insights into predisposing factors and potential high-risk genetic variants are warranted. This article reviews advancements in quantitative and molecular genetics in refining estimation of genetic parameters and identifying predisposing genetic loci. Heritabilities were highest for hock OC with estimates at 0.29-0.46 in Hanoverian warmblood and Norwegian trotters, whereas in Thoroughbreds only very low genetic variation seemed to be present in hock OC lesions. Whole genome scans using the Illumina Equine SNP50 or SNP70 Beadchip were performed in Thoroughbred, Standardbred, French and Norwegian trotter, Hanoverian and Dutch warmblood. Validation studies in Spanish Purebred and Hanoverian warmblood horses corroborated OC risk loci on ECA 3, 14, 27 and 29. Particularly, a strong association with hock-OCD was found for a single nucleotide polymorphism (SNP) on horse chromosome (ECA) 3 upstream to the LCORL gene. Gene expression and microRNA analyses may be helpful to understand pathophysiological processes in equine OC and to connect OCD-associated genomic regions with potential candidate genes. Furthermore progress in elucidating the underlying genetic variants and pathophysiological changes in OC may be expected from whole genome DNA and RNA next-generation sequencing studies.

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Section: Linked and Associated Risk Loci For Osteochondrosismentioning

confidence: 84%

Genetic risk factors for osteochondrosis in various horse breeds

Naccache

Metzger

Distl

2018

Equine Veterinary Journal

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“…To date, there is no comparative literature for deformity in any aquatic animal species. Reports in terrestrial livestock species indicated that QTL regions on chromosome 26 are associated with bone related diseases ( Rafati et al, 2016 ; Sevane et al, 2016 ). However, no markers were detected to be associated with skin fluke ( Supplementary File S6 ).…”

Section: Discussionmentioning

confidence: 99%

First High-Density Linkage Map and Single Nucleotide Polymorphisms Significantly Associated With Traits of Economic Importance in Yellowtail Kingfish Seriola lalandi

et al. 2018

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The genetic resources available for the commercially important fish species Yellowtail kingfish (YTK) (Seriola lalandi) are relative sparse. To overcome this, we aimed (1) to develop a linkage map for this species, and (2) to identify markers/variants associated with economically important traits in kingfish (with an emphasis on body weight). Genetic and genomic analyses were conducted using 13,898 single nucleotide polymorphisms (SNPs) generated from a new high-throughput genotyping by sequencing platform, Diversity Arrays Technology (DArTseqTM) in a pedigreed population comprising 752 animals. The linkage analysis enabled to map about 4,000 markers to 24 linkage groups (LGs), with an average density of 3.4 SNPs per cM. The linkage map was integrated into a genome-wide association study (GWAS) and identified six variants/SNPs associated with body weight (P < 5e-8) when a multi-locus mixed model was used. Two out of the six significant markers were mapped to LGs 17 and 23, and collectively they explained 5.8% of the total genetic variance. It is concluded that the newly developed linkage map and the significantly associated markers with body weight provide fundamental information to characterize genetic architecture of growth-related traits in this population of YTK S. lalandi.

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“…Studies by Sevane et al . () on Spanish Purebred Horses did not confirm such results. We believe that the horse breed used in our studies may have largely contributed to the results being divergent from the results reported by Wittwer et al .…”

Section: Genotype Frequencies Of Investigated Loci and Significance Omentioning

confidence: 76%

Polymorphisms in selected genes and analysis of their relationship with osteochondrosis in Polish sport horse breeds

et al. 2018

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The aim of this research was to evaluate the polymorphisms of selected genes and to find their potential effect on the occurrence of osteochondrosis in Polish Warmbloods (sport horse breeds). The study was conducted on a group of 198 horses subjected to official performance tests. Investigated joints-fetlock, hock and stifle-were X-rayed twice, once before and again at the end of the tests (first and second examination), and on this basis the degree of disease was evaluated. Based on the results of previous research, 13 candidate genes potentially associated with the occurrence of osteochondrosis were selected and, among them, 32 polymorphisms were tested. Seven SNPs located in the MATN1, CPVL, HYAL1, XIRP2, FRZB, COL5A2 and IGF1 genes were found to be associated with occurrence of osteochondrotic lesions in different joints. These intragenic polymorphisms seem to provide valuable information about the genetic basis of osteochondrosis in sport horse breeds.

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Candidate gene analysis of osteochondrosis in Spanish Purebred horses

Cited by 9 publications

References 47 publications

Genetic risk factors for osteochondrosis in various horse breeds

Genetic risk factors for osteochondrosis in various horse breeds

First High-Density Linkage Map and Single Nucleotide Polymorphisms Significantly Associated With Traits of Economic Importance in Yellowtail Kingfish Seriola lalandi

Polymorphisms in selected genes and analysis of their relationship with osteochondrosis in Polish sport horse breeds

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