Candidate Biomarkers for Fatigue in Systemic Lupus Erythematosus: A Critical Review

Mahieu, Mary A.; Ramsey‐Goldman, Rosalind

doi:10.2174/1573397112666161029224953

Cited by 5 publications

(5 citation statements)

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“…In addition to diets, we inquired about dietary supplements. It was no surprise to see that 70% of patients took supplements as common symptoms of lupus include vitamin D and iron deficiency; 18 Figure 4 Research questions important to lupus patients. Text cloud analysis, using 'wordcloud' software, of free text from an optional question in the survey asking for patient ideas for research.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to diets, we inquired about dietary supplements. It was no surprise to see that 70% of patients took supplements as common symptoms of lupus include vitamin D and iron deficiency; 18 however, only 7% of the patients taking supplements took fish oils, known to have health benefits, 19 modify blood lipid profiles 20,21 and reduce cardiovascular risk, which is high in lupus patients. 22…”

Section: Discussionmentioning

confidence: 99%

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Diet and lupus: what do the patients think?

Robinson

McDonnell

Wincup

et al. 2019

Lupus

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Objectives Cardiovascular disease (CVD) is the leading cause of mortality in patients with systemic lupus erythematosus (lupus). Therefore, using diet to control blood lipid levels and modify CVD risk could be a promising therapeutic strategy to control disease symptoms. The primary objective of this study was to learn about lupus patient experiences with diet including their opinion on considering diet as a therapeutic option. The secondary objective was to obtain this information in a cost and time effective manner. Methods A lay summary and a 15 question diet-based online survey was publicly available for 3 weeks. Social media was used to promote the survey through relevant charities, hospitals and research groups. Results 300 responses were received, 284 of whom had lupus. Patients reported that there was a lack of clinical counselling regarding diet with only 24% of patients stating that their doctor had spoken to them about diet. Despite this, 100% of patients stated that they would change their diet if they knew it would help their symptoms and 83% would take part in a future diet-based clinical trial. Text analysis of patient research suggestions identified a particular interest in using diet to treat fatigue

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Section: Discussionmentioning

confidence: 99%

“…In addition to diets, we inquired about dietary supplements. It was no surprise to see that 70% of patients took supplements as common symptoms of lupus include vitamin D and iron deficiency; 18 however, only 7% of the patients taking supplements took fish oils, known to have health benefits, 19 modify blood lipid profiles 20,21 and reduce cardiovascular risk, which is high in lupus patients. 22…”

Section: Discussionmentioning

confidence: 99%

Diet and lupus: what do the patients think?

Robinson

McDonnell

Wincup

et al. 2019

Lupus

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Section: Vitamin D and Its Major Extra-musculoskeletal Impactsmentioning

confidence: 99%

“…Up to 80% of patients with SLE report symptoms of fatigue during their disease course [95]. Fatigue in SLE patients has been found to be related to low serum vitamin D levels [95,96,97,98,99]. A cross-sectional study of 90 patients with SLE found that those with vitamin D deficiency (25-(OH)D 3 ≤10 ng/mL) reported higher fatigue scores that those with adequate vitamin D levels [100].…”

Section: Vitamin D and Its Major Extra-musculoskeletal Impactsmentioning

confidence: 99%

The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus

Mak

2018

IJMS

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Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The mechanistic roles that vitamin D plays regarding immune activation for combating infection, as well as pathologically and mediating autoimmune conditions, have been progressively unraveled. In vitro and in vivo models have demonstrated that the action of vitamin D on various immunocytes is not unidirectional. Rather, how vitamin D affects immunocyte functions depends on the context of the immune response, in the way that its suppressive or stimulatory action offers physiologically appropriate and immunologically advantageous outcomes. In this review, the relationship between various aspects of vitamin D, starting from its adequacy in circulation to its immunological functions, as well as its autoimmune conditions, in particular systemic lupus erythematosus (SLE), a prototype autoimmune condition characterized by immune-complex mediated inflammation, will be discussed. Concurring with other groups of investigators, our group found that vitamin D deficiency is highly prevalent in patients with SLE. Furthermore, the circulating vitamin D levels appear to be correlated with a higher disease activity of SLE as well as extra-musculoskeletal complications of SLE such as fatigue, cardiovascular risk, and cognitive impairment.

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“…It is therefore a ferric parameter very indispensable in the differential diagnosis of iron deficiency anaemia, ferropenia with or without anaemia, evaluation of ferric status. In some situations of inflammatory processes, ferritin may be increased, even in inflammatory anaemia, autoimmune diseases such as rheumatoid arthritis and others with hepatic injury [17].…”

Section: Ferritinmentioning

confidence: 99%

Ferritin: Could be a Health Indicator

M¹,

L²

2018

J Fam Med Dis Prev

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• AbstractHealth indicators show a health-related characteristic that allows the study, evaluation and conclusion of a health process. Therefore, it allows us to influence public health policies to obtain an improvement in the health status of the population.Iron deficiency is one of the most prevalent forms of malnutrition, without quality of life and can present in anaemia, with reduce of hemoglobin (it causes 50% of anaemia around the world) and in ferropenia, iron deficiency, without anaemia. The iron deficiency has a very heavy rates of mortality associated of it.The iron element is a d-block transition element with an oxidation changeable ranging between -2 and 6+ which makes iron to be in different biological ways: ferrous (Fe 2+ ), ferric (Fe 3+ ), or ferryl (Fe. This capacity allows iron to bind to manifold ligands/proteins of the human organism, which are essential for all living cells; to participate in many metabolic and energetic pathways, like a production of energy in mitochondria, binding and transport of oxygen, regulation of cell growth and differentiation, synthesis and packaging of neurotransmitters and degradation of catecholamines [2], synthesis of the deoxyribonucleic acid or DNA [3] and others.As free iron is toxic to cells, it is stored complexed to protein as ferritin. Thus, the serum ferritin level correlates with a total body iron, could discard ferropenia (iron deficiency without anaemia) and establish he quality of life.Women, especially in their fertile stage, tend to have lower values because of menstrual losses, even during normal menses. In this small text we will try to reflect on how ferritin can be a parameter of evaluation of quality of life and normality of body functions.

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Candidate Biomarkers for Fatigue in Systemic Lupus Erythematosus: A Critical Review

Cited by 5 publications

References 0 publications

Diet and lupus: what do the patients think?

Diet and lupus: what do the patients think?

The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus

Ferritin: Could be a Health Indicator

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