Candida species in community-acquired pneumonia in patients with chronic aspiration

Moss, Benjamin; Musher, Daniel M.

doi:10.1186/s41479-021-00090-x

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…Patients with CAP who had large amounts of Candida spp in their respiratory samples all had a history consistent with aspiration and in each case was polymicrobial infection, suggesting a contributing role of Candida spp in the etiology of AspRF-CAP. 41 …”

Section: Discussionmentioning

confidence: 99%

Microbiological Profile of Patients with Aspiration Pneumonia Identified by Combined Detection Methods

Xu,

Zhang,

Zhang

et al. 2024

IDR

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Purpose Aspiration pneumonia (AP) challenges public health globally. The primary aim of this study was to ascertain the microbiological profile characteristics of patients with AP evaluated by combined detection methods, including conventional microbiological tests (CMTs), chips for complicated infection detection (CCID), and metagenomic next-generation sequencing (mNGS). Patients and Methods From June 2021 to March 2022, a total of thirty-nine patients with AP or community-acquired pneumonia with aspiration risk factors (AspRF-CAP) from 3 hospitals were included. Respiratory specimens, including bronchoalveolar lavage fluid (BALF), sputum, and tracheal aspirate, were collected for microorganism detection. Results Patients with AP were more inclined to be older, to have a shorter duration from illness onset to admission, to have a higher prevalence of different underlying diseases, particularly diabetes mellitus, chronic heart disease, and cerebrovascular disease, and to have a higher CURB-65 score (all P < 0.05). A total of 213 and 31 strains of microorganisms were detected in patients with AP and AspRF-CAP, respectively. The most common pathogens in AP were Corynebacterium striatum (17/213, 7.98%), Pseudomonas aeruginosa (15/213, 7.04%), Klebsiella pneumoniae (15/213, 7.04%), and Candida albicans (14/213, 6.57%). Besides, the most common pathogens in AspRF-CAP were Candida albicans (5/31, 16.13%), Pseudomonas aeruginosa (3/31, 9.68%) and Klebsiella pneumoniae (3/31, 9.68%). Moreover, Klebsiella pneumoniae (7/67, 10.45%) and Candida glabrata (5/67, 7.46%) were the most common pathogens among the 9 non-survived patients with AP. Conclusion The prevalent pathogens detected in cases of AP were Corynebacterium striatum, Pseudomonas aeruginosa, Klebsiella pneumoniae , and Candida albicans . Early combined detection methods for patients with AP enhance the positive detection rate of pathogens and potentially expedites the initiation of appropriate antibiotic therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Microbiological Profile of Patients with Aspiration Pneumonia Identified by Combined Detection Methods

Xu,

Zhang,

Zhang

et al. 2024

IDR

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“…Severe pneumonia is a common condition found among patients admitted to the Intensive Care Unit (ICU). 1 1154652H ICXXX10.1177/23247096231154652Journal of Investigative Medicine High Impact Case ReportsBriones-Claudett et al research-article20232023 1 Universidad de Las Americas, Quito, Ecuador 2 Ecuadorian Institute of Social Security, Babahoyo, Ecuador 3 OMNI Hospital, Guayaquil, Ecuador 4 Physiology and Respiratory-Center Briones-Claudett, Ecuador 5 Centro de Investigación Microbiológica, Guayaquil, Ecuador 6 Universidad Espíritu Santo, Samborondón, Ecuador 7 Universidad de Guayaquil, Ecuador 8 Universidad San Francisco de Quito, Ecuador…”

Section: Introductionmentioning

confidence: 99%

“…1 Pneumonia can be categorized into 3 according to site of acquisition and development: (1) community-acquired pneumonia (CAP), (2) hospital-acquired pneumonia (HAP), and (3) ventilator-associated pneumonia (VAP). 2 A wide spectrum of pathogens responsible for pneumonia has been established, with bacteria being the most representative pathogen identified. Bronchoalveolar lavage (BAL) is essential in identifying the pathogen, especially in patients with clinical features very suggestive of pneumonia.…”

Section: Introductionmentioning

confidence: 99%

An Unusual Case of Severe Pneumonia Caused Due Candida Tropicalis With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community

Claudett

Briones-Claudett²,

Vasconez³

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient. A 72-year-old man with a previous history of hypertension, ischemic stroke, and facial paralysis sequelae treated with the botulinic toxin, was admitted to the hospital for dyspnea. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection was negative. Computed tomography of the chest revealed bilateral consolidation with left predominance. A bronchoalveolar lavage sample was sent to molecular biology, but no microorganisms were detected using a FilmArray respiratory panel. However, mamanocandidas test for candida was 166 pg/mL (positive), and fungal structures were identified by the MALDI-TOF Biotyper mass spectrometry and attributed to C tropicalis. Antifungal therapy was started using caspofungin 75 mg as the initial dose followed by 50 mg daily. After 10 days of treatment, ventilatory weaning was achieved. By day 14, the patient was decannulated from the tracheostomy. Oral antifungal treatment with voriconazole was continued, and he was discharged from intensive care in good clinical condition. Severe pneumonia due to C tropicalis might occur in specific cases, especially in those patients with risk factors, and must thus be considered when approaching such cases.

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“…However, Candida spp. can cause thrush or even pneumonia in severely immunocompromised patients [3,4]. It was also found that Candida spp.…”

mentioning

confidence: 99%

“…It was also found that Candida spp. never caused pneumonia alone but contributed to the pathological process in association with bacterial pathogens or opportunistic members of normal respiratory bacterial microbiota [3]. That is why the microbe-microbe interactions within the oral microbiome including inter-kingdom fungal-bacterial signalling affecting microbial pathogenicity have attracted increasing attention [4].…”

mentioning

confidence: 99%

Molecular genetic identification of yeast isolate MF22_1

Fomina¹,

Filipishena²,

Polishchuk³

2022

Fiziol.rast. genet.

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Microscopic fungi including yeasts are important part of human microbiota. Among them, yeasts of genus Candida are very common and often the most predominant part of mycobiota. Candida spp., including Candida albicans and non-Candida albicans species, can be opportunistic pathogens affecting people with depressed immune system. The problem with some non-Candida albicans species, e.g. C. glabrata and C. krusei, is that they are highly resistant to antifungal therapy and, at the same time, difficult to identify accurately at the species level by widely clinically used conventional biochemical methods. The aim of this work was precise molecular genetic identification of human sputum yeast isolate MF22_1, allegedly belonging to Candida spp., by using multiple genetic markers. We used four fragments of its chromosomal DNA, which were sequenced and deposited by us in GenBank NCBI database: 1) ITS (GenBank OM479428, 548 bp), 2) 28S rRNA (OM479513, 607 bp), 3) 18S rRNA (OM4794321, 737 bp), and 4) RNA polymerase II gene -RPB2 (OM524388, 1,217 bp). The part of Nucleotide collection database [http://www.ncbi.nlm.nih.gov/nuccore/] containing information on the nucleotide structure of fungal DNA (taxid: 4751) was studied using BLASTN [http://blast.ncbi.nlm.nih.gov/Blast.cgi]. The BLASTN analysis established that all four sequenced genetic markers: ITS, 28S rRNA, 18S rRNA, and RPB2 of the studied isolate MF22_1 had the maximum similarity to the corresponding sequences of the type strains of Pichia kudriavzevii species. Therefore, it was confirmed that the isolate belonged to species Pichia kudriavzevii, which anamorph (or non-ascosporic state) is Candida krusei. This ubiquitous in the environment species is a common clinical isolate responsible for about 2 % incidences of yeast infections caused by Candida species in humans. Comparative analysis of a primary structure of ITS region demonstrated the great similarity of the ITS sequence of Pichia kudriavzevii MF22_1 to the majority of other Pichia kudriavzevii clinical isolates from human sputum, stool, blood etc., which are preserved in different culture collection of the institutions specializing in medical studies of yeasts around the world. For these clinical isolates of Pichia kudriavzevii, no clear correlation was observed between the similarity of ITS sequences and the type of biomaterial sampled from humans.

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Candida species in community-acquired pneumonia in patients with chronic aspiration

Cited by 8 publications

References 24 publications

Microbiological Profile of Patients with Aspiration Pneumonia Identified by Combined Detection Methods

Microbiological Profile of Patients with Aspiration Pneumonia Identified by Combined Detection Methods

An Unusual Case of Severe Pneumonia Caused Due Candida Tropicalis With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community

Molecular genetic identification of yeast isolate MF22_1

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