Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008

Ortega, M.; Marco, Francesc; Soriano, Álex; Almela, Manel; Martínez, J. A.; López, Josefina; Pitart, Cristina; Mensa, José

doi:10.1016/j.jhin.2010.09.026

Cited by 128 publications

(93 citation statements)

References 28 publications

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“…Studies have indicated an apparent decrease in the infection rates of C. albicans in recent decades but an increase in infections caused by NCAC species 8 , which corroborates the results of the present study, in which C. albicans represented only 36% of the isolates, whereas NCAC species (C. tropicalis, C. glabrata, and C. krusei) represented the majority of isolates (64%). These results are similar to other recent studies conducted in central-western Brazil.…”

Section: Discussionsupporting

confidence: 92%

“…There have been, however, increases in HI caused by non-C. albicans Candida (NCAC) species such as C. tropicalis, C. glabrata, C. parapsilosis, and C. krusei [6][7][8] . The occurrence of infections caused by these yeasts is relevant to HI vigilance because these micro-organisms have varying virulence attributes and profi les of antifungal drug sensitivity, including recent reports of resistance to the principal antifungal drugs currently administered in hospitals 9,10 .…”

Section: Introductionmentioning

confidence: 99%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Hospital infections caused by Candida spp. are a leading cause of morbidity and mortality in hospitalized patients, particularly those that are critically ill or immunocompromised. In this study, the distributio n of Candida species in isolates from the University Hospital of the Federal University at Grande Dourados and their in vitro susceptibility to antifungal drugs were analyzed. Methods: Yeasts were phenotypically identifi ed using classical methodologies. Antifungal susceptibility tests to amphotericin B and fl uconazole were performed using the broth microdilution technique. Results: A total of 50 Candida isolates were obtained from hospitalized patients during the study period. We analyzed yeast isolates from urine (n=31; 62%), blood (n=12; 24%), and tracheal secretions (n=7; 14%). The following Candida species were identifi ed: C. tropicalis (n=21; 42%), C. albicans (n=18; 36%), C. glabrata (n=10; 20%), and C. krusei (n=1; 2%). Antifungal susceptibility tests demonstrated that C. albicans was susceptible to both antifungal agents. However, 31.2% of the non-C. albicans Candida isolates displayed dose-dependent susceptibility to fl uconazole, and 3.1% were resistant to amphotericin B. Conclusions: In contrast to previous reports, our results indicated that C. tropicalis was the most commonly isolated yeast species among the hospital patients. The predominance of non-C. albicans Candida infections confi rms the importance of species-level identifi cation for implementing appropriate antifungal therapies.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…28 C. glabrata has been associated with prior use of azoles, and transplants of solid organ and hematopoietic cells. 2,[29][30][31] Some Candida spp. were isolated between 2011 and 2013: Candida kefyr, Candida krusei and Fusarium sp.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Castro

Schütze

Bücker

et al. 2016

Rev. Assoc. Med. Bras.

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“…3 The extensive use of antifungals for prophylaxis became the leading cause of colonization of non-albicans Candida (NAC) species and increasing resistance to antifungal drugs. 4 Drug resistance to azoles is emerging, hence early speciation and antifungal susceptibility pattern helps in guiding the physician in choosing the appropriate antifungal drug and thus prevent therapeutic failures.…”

Section: Introductionmentioning

confidence: 99%

Rapid identification and susceptibility pattern of various Candida isolates from different clinical specimens in a tertiary care hospital in Western Uttar Pradesh

et al. 2017

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Background: Candida species are component of normal flora of human beings. Candidiasis is the commonest fungal disease affecting mucosa, skin, nails and internal organs. A variety of predisposing factors are known to cause candidiasis either by altering balance of normal microbial flora of the body or by lowering the host defence.Methods: A total of 90 specimens submitted in the department of microbiology were included in this study. Identification of Candida species as well as antifungal sensitivity testing was performed with Vitek®2 compact (Biomerieux France) using Vitek2 cards for identification of yeast and yeast like organisms (ID-YST cards). Antifungal susceptibility testing was performed using Vitek2 fungal susceptibility card (AST YS01) kits respectively.Results: The distribution of the clinical samples were urine 53 (58.9%), sputum 14 (15.5%), blood 10 (11.1%), nail 6 (6.7%) and high vaginal swab 7 (7.8%). Among 90 clinical isolates, species obtained were C. tropicalis 53 (59%), C. albicans 23 (25.5%), C. glabrata 6 (6.7%), C. parapsilosis 4 (4.4%), C. krusei 2 (2.2%), C. pelliculosa 1 (1.1%), C. famata 1 (1.1%).Conclusions: Infections caused by non-candida albicans species have increased. Identification of Candida species and their antifungal susceptibility are important for the treatment of hospitalized patients with serious underlying disease.

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Candida species bloodstream infection: epidemiology and outcome in a single institution from 1991 to 2008

Cited by 128 publications

References 28 publications

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Prevalence of fungemia in a tertiary hospital: Analysis of the last decade

Rapid identification and susceptibility pattern of various Candida isolates from different clinical specimens in a tertiary care hospital in Western Uttar Pradesh

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