Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis

Tasso, Camilla Olga; Ferrisse, Túlio Morandin; de Oliveira, Analú Barros; Ribas, Beatriz Ribeiro; Jorge, Janaina Habib

doi:10.1016/j.canep.2023.102451

Cited by 2 publications

(1 citation statement)

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“…Additionally, Candida albicans poses a risk for oral squamous cell carcinoma due to its capacity to stimulate the production of carcinogenic substances, including endogenous nitrosamines. Specifically, Candida albicans can transform nitrite into nitrosamines, concurrently producing acetaldehyde, which plays a carcinogenic role in the oral cavity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Red/Orange Autofluorescence in Selected Candida Strains Exposed to 405 nm Laser Light

Wiench,

Paliga,

Mertas

et al. 2024

Dentistry Journal

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Background: Candida albicans and similar species are significant pathogens in immunocompromised and hospitalized individuals, known for mucosal colonization and bloodstream/organ invasion. Many pathogenic fungi, including these species, exhibit autofluorescence (R/OF) under specific light conditions, a feature crucial for their detection. Aim: We investigated the use of a 405 nm diode laser for the direct observation of red/orange autofluorescence of Candida spp., common in the oral cavity, exploring its potential in health screenings. Methods: This study utilized cultures of Candida spp. on Sabouraud dextrose agar with Qdot 655 and 685 for fluorescence benchmarking, illuminated using a 405 nm diode laser (continuous wave, power 250 mW, 0.0425 J/cm² fluence, 0.0014 W/cm² power density). Images were captured using a yellow-filter camera at set intervals (48 to 144 h). Visual and computational analyses evaluated the R/OF in terms of presence, intensity, coloration, and intra-colony variation. Results: Most Candida strains displayed red/orange autofluorescence at all observation times, characterized by varied coloration and intra-colony distribution. Initially, there was an increase in R/OF intensity, which then stabilized in the later stages of observation. Conclusions: The majority of the Candida strains tested are capable of emitting R/OF under 405 nm laser light. This finding opens up new possibilities for integrating R/OF detection into routine dental screenings for Candida spp.

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Section: Introductionmentioning

confidence: 99%

Red/Orange Autofluorescence in Selected Candida Strains Exposed to 405 nm Laser Light

Wiench,

Paliga,

Mertas

et al. 2024

Dentistry Journal

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Fungal footprints in oral cancer: unveiling the oral mycobiome

Monteiro,

Kaushik,

de Arruda

et al. 2024

Front. Oral. Health

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Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer, with a high mortality rate. There is growing evidence supporting a link between oral cancer and the microbiome. The microbiome can impact various aspects of cancer, such as pathogenesis, diagnosis, treatment, and prognosis. While there is existing information on bacteria and its connection to oral cancer, the fungi residing in the oral cavity represent a significant component of the microbiome that remains in its early stages of exploration and understanding. Fungi comprise a minuscule part of the human microbiome called the mycobiome. Mycobiome is ubiquitous in the human body but a weakened immune system offers a leeway space for fungi to showcase its virulence. The role of mycobiome as a colonizer, facilitator, or driver of carcinogenesis is still ambiguous. Reactivating the mycobiome that undergoes collateral damage associated with cancer treatment can be watershed event in cancer research. The coordinated, virulent, non-virulent behavior of the fungi once they reach a critical density must be hacked, considering its diagnostic, prognostic and therapeutic implications in cancer. This review highlights the diversity of the mycobiome and its potential role in oral cancer.

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Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis

Cited by 2 publications

References 43 publications

Red/Orange Autofluorescence in Selected Candida Strains Exposed to 405 nm Laser Light

Red/Orange Autofluorescence in Selected Candida Strains Exposed to 405 nm Laser Light

Fungal footprints in oral cancer: unveiling the oral mycobiome

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