Candida parapsilosis meningitis in a patient with AIDS. Report of a case and review of the literature

Corti, Marcelo; Solari, Hernán G.; Carolis, Luis De; Cangelosi, Diana; Arechavala, Alicia; Negroni, Ricardo

doi:10.1016/j.riam.2012.11.003

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…Risk factors for invasive candidiasis include neurosurgical interventions, previous treatment with antibiotics, parenteral nutrition, abdominal surgery, and an immunocompromised state such as HIV/AIDS, malignancy, or chronic steroid use (13,14). Increasingly, non-C. albicans etiologies of meningitis have been reported, like C. tropicalis, C. parapsilosis, and C. glabrata (14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Candida dubliniensis as a Cause of Chronic Meningitis

2020

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Background:Candida dubliniensis is closely related to Candida albicans and rarely isolated in clinical specimens. C. dubliniensis is increasingly recognized as a pathogen in immunocompromised hosts. We present the third known case of Candida dubliniensis meningitis in a young immunocompetent host.Case Presentation: A 27-year-old female with a history of intravenous heroin use and chronic hepatitis C presented with a 10-month history of headaches and progressive bilateral vision loss. On physical examination, visual acuity was 20/20 in her right eye and grade II papilledema was noted. Examination of her left eye revealed complete loss of vision and grade IV papilledema. An MRI with and without contrast revealed increased leptomeningeal enhancement involving the posterior fossa and spinal cord. After multiple lumbar punctures, cerebrospinal fluid fungal cultures grew Candida dubliniensis. The patient was successfully treated with a combination of liposomal amphotericin and fluconazole for 6 weeks with complete resolution of her CNS symptoms, with the exception of irreversible vision loss.Conclusion: We report a case of chronic meningitis due to Candida dubliniensis in an immunocompetent woman with hepatitis C and a history of intravenous heroin use. Additional studies are needed to confirm risk factors for Candida dubliniensis colonization, which likely predisposes individuals to invasive candidiasis.

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Section: Discussionmentioning

confidence: 99%

Case Report: Candida dubliniensis as a Cause of Chronic Meningitis

2020

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“…Selective susceptibility for CMC is seen in rare patients suffering from infections with persistence and recurrence along with severe debilitating property. From this knowledge it was termed as chronic mucocutaneous candidiasis [21].…”

Section: Related Workmentioning

confidence: 99%

A study on fungal speciation and drug susceptibility testing

Mujafar¹,

Ganesh²,

J³

et al. 2020

ijntps

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Fungal infections affect many people but most of these do not come to light as they are mild in clinical presentation. Candidiasis is the frequent fungal infection involving mucosa, skin, nails and internal organs caused by different species of Candida and Candida albicans being the prototype. The clinical manifestations vary with duration and severity. It occurs mostly as a comorbid disease with a primary disease or disorder. Candida comes under the phylum Fungi Imperfecti, order Moniliales and family Cryptococcaceae. Genus Candida comprises of 20 important species recognised as pathogenic in humans, of which 7 are renowned opportunistic pathogens. The following are some of the known species: Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Candida guilliermondii, Candida parapsilosis, Candida lusitaniae, Candida kefyr, Candida rugosa, Candida dubliniensis and Candida viswanathii. Among all the fungi, 600 species are identified to be causing infections in human. Candida albicans being one of the normal human commensals may cause infections from mild to severe forms, which is influenced by molecules that helps in adhesion and invasion, hydrolases, yeast to hyphal transition, biofilms etc. In general, equal importance has not been give to fungal infections as is being given for bacterial infections. Nowadays newly emerging species are on the tract as to cause infections and their identification profile being indeterminate, which could be confirmed only by molecular methods. Overall C.tropicalis was the frequent species causing infections clinically and resistance was demonstrated against azoles and caspofungin by C.albicans and C.krusei. This may be due to extensive use of echinocandins as empirical therapy without susceptibility testing which can increase the development of resistance and may deduct treatment options. Hence, routine antifungal susceptibility testing has to be done. Out of all these things accurate epidemiological analysis and data can be provided regarding the burden of fungal infections around the globe. As tip of the iceberg, most of the fungal infections are not being reported as it is unnoticed without prominent clinical presentation and due to lack of complete documentation.

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Fungal Infections of the Central Nervous System

Carod-Artal

2017

CNS Infections

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Candida parapsilosis meningitis in a patient with AIDS. Report of a case and review of the literature

Cited by 8 publications

References 21 publications

Case Report: Candida dubliniensis as a Cause of Chronic Meningitis

Case Report: Candida dubliniensis as a Cause of Chronic Meningitis

A study on fungal speciation and drug susceptibility testing

Fungal Infections of the Central Nervous System

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