Candida parapsilosis as a Causative Agent of Onychomycosis in Patient with Cirrhosis of the Liver

Kukhar, Yelena; Smagulova, Ainura; Daniyarova, Ainash; Baiduissenova, Aliya; Kiyan, Vladimir

doi:10.3390/jof6040313

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, C. abidance (30.9%) and C. parapsilosis (27.3%) subsequently were the most frequent yeasts isolated of infected nails. This finding was similar to other studies ( 18 – 20 ).…”

Section: Discussionsupporting

confidence: 94%

The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020

Razavyoon¹,

Hashemia²,

Mansouri³

et al. 2022

IJM

View full text Add to dashboard Cite

Background and Objectives: Onychomycosis is caused by dermatophyte species, non- dermatophyte moulds (NDMs), and accounts for roughly 50% of all nail diseases. As the prevalence of onychomycosis is increasing, new epidemiologic documents may help with treatment and prevention. The present investigation aims to determine the epidemiological profile of onychomycosis in 2 mycology laboratories. Materials and Methods: A cross-sectional study conducted during eight months (2019-2020) on 169 patients with positive nail mycology tests referred to two mycological laboratory centers affiliated with Tehran University of Medical Science. The nail clippings were examined by direct smear and culture. Also, molecular assays were performed if needed. Results: 10% of nail lesions referred to Razi Hospital (RH), and 30% of nail lesions referred to TUMS mycology laboratory were positive. Middle age (40-60) suffer more from onychomycosis. Aspergillus flavus, Trichophyton mentagrophytes, and Candida albicans were the most common etiologic agents in each of the three main classes of fungi causing onychomycosis. Females were more infected. NDMs were the predominant etiologic agents, and toenails were the most common site of onychomycosis. Conclusion: The pattern of etiologic agents and clinical signs of onychomycosis differs according to geographical region and age, so repeated epidemiological surveys of onychomycosis seem to be fundamental.

show abstract

“…Also, C. abidance (30.9%) and C. parapsilosis (27.3%) subsequently were the most frequent yeasts isolated of infected nails. This finding was similar to other studies ( 18 – 20 ).…”

Section: Discussionsupporting

confidence: 94%

The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020

Razavyoon¹,

Hashemia²,

Mansouri³

et al. 2022

IJM

View full text Add to dashboard Cite

show abstract

“…It causes discoloration, thickening, fragility and eventual nail bed separation (Andrés & Alexandro, 2020). Over the years, Candida parapsilosis has been the most common Candida species for infections of the fingers and toes (Kukhar et al, 2020), and C. tropicalis (Arrua et al, 2015) has emerged as the second‐line pathogen causing onychomycosis (Torres‐Guerrero & Arenas, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of 2-chloro-N-phenylacetamide, docking and molecular dynamics studies against clinical isolates of Candida tropicalis and Candida parapsilosis

Silva

Pereira

Cordeiro

et al. 2022

Journal of Applied Microbiology

View full text Add to dashboard Cite

Aims This study evaluated the antifungal, antibiofilm and molecular docking of 2‐chloro‐N‐phenylacetamide against clinical isolates of Candida tropicalis and Candida parapsilosis. Methods and results Minimum inhibitory concentration (MIC) of the test drugs was determined by microdilution. A1Cl obtained MIC values ranging from 16 and 256 μg/ml. Fluconazole MIC ranging from 16 and 512 μg/ml. MIC of A1Cl showed fungicide activity, emphasizing the solid antifungal potential of this drug. An association study was performed with A1Cl and fluconazole (checkerboard), revealing indifference by decreasing. Thus, we conducted this study using A1Cl isolated. In the micromorphological assay, the test drugs reduced the production of virulence structures compared to the control (concentration‐dependent effect). A1Cl inhibited in vitro biofilm formation at all concentrations tested (1/4MIC to 8 × MIC) (p < 0.05) and reduced mature biofilm biomass (p < 0.05) against C. tropicalis and C. parapsilosis. In the ex vivo biofilm susceptibility testing (human nails fragments), A1Cl inhibited biofilm formation and reduced mature biofilm biomass (p < 0.05) more than 50% at MIC. Fluconazole had a similar effect at 4 × MIC. In silico studies suggest that the mechanism of antifungal activity of A1Cl involves the inhibition of the enzyme dihydrofolate reductase (DHFR) rather than geranylgeranyltransferase‐I. Conclusions The results suggest that A1Cl is a promising antifungal agent. Furthermore, this activity is related to attenuation of expression of virulence factors and antibiofilm effects against C. tropicalis and C. parapsilosis. Significance and impact of the study Our study provides the first evidence that A1Cl, a novel synthetic drug, has fungicidal effects against C. tropicalis and C. parapsilosis. Furthermore, in vitro and ex vivo biofilms assays have demonstrated the potential antibiofilm of A1Cl. The mechanism of action involves inhibiting the enzyme DHFR, which was supported by in silico analyses. Therefore, this potential can be explored as a therapeutic alternative for onychomycosis and, at the same time, contribute to decreasing the resistance of clinical isolates of C. tropicalis and C. parapsilosis.

show abstract

Fungal Melanonychia as a Solitary Black Linear Vertical Nail Plate Streak: Case Report and Literature Review of Candida-Associated Longitudinal Melanonychia Striata

Cohen¹,

Shurman²

2021

Cureus

View full text Add to dashboard Cite

Longitudinal melanonychia striata, presenting as a black linear vertical band of the nail plate, can be caused by pigmented lesions and non-pigmented etiologies. A fungal infection of the nail plate, also referred to as onychomycosis or tinea unguim, can result from dermatophytes, non-dermatophyte molds, and Candida . Albeit rare, Candida -associated fungal melanonychia can present as a longitudinal black nail plate streak. The case of a 79-year-old man who developed a solitary linear black streak on his right fourth fingernail after a prior history of recent trauma to the digit’s nail folds is described; the fungal culture grew Candida parapsilosis . Including our patient, Candida -associated longitudinal melanonychia striata has been described in four women and two men ranging in age from 40 to 79 years (median, 70 years) at diagnosis. The black streak, present from one month to one year (median, seven months), affected either a hand digit (five patients) or the great toe (one patient). Fungal organisms were visualized on either a potassium hydroxide preparation (one patient), pathologic evaluation of a nail plate specimen (three patients), or both (one patient). Culture grew Candida parapsilosis (two patients), Candida species (two patients), Candida albicans (one patient), and Candida tropicalis (one patient). All of the patients experienced clinical improvement after treatment. Topical treatment (5% amorolfine hydrochloride nail lacquer for two patients or modified Castellani paint and 1% clotrimazole cream for one man) or oral itraconazole (either as monotherapy for two women or combined with 5% amorolfine hydrochloride nail lacquer for one woman) was successfully used. Although the clinical presentation of fungal melanonychia can mimic subungual melanoma when it appears as a solitary black linear vertical nail plate streak, investigative studies--such as a potassium hydroxide preparation, nail plate pathology, nail matrix biopsy, and/or fungal culture--can be used to establish the diagnosis of Candida -associated longitudinal melanonychia striata and exclude the diagnosis of a pigmented melanocytic tumor.

show abstract

Candida parapsilosis as a Causative Agent of Onychomycosis in Patient with Cirrhosis of the Liver

Cited by 3 publications

References 15 publications

The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020

The epidemiology and etiology of onychomycosis in 2 laboratory centers affiliated to Tehran university of medical sciences during 2019-2020

Antifungal activity of 2-chloro-N-phenylacetamide, docking and molecular dynamics studies against clinical isolates of Candida tropicalis and Candida parapsilosis

Fungal Melanonychia as a Solitary Black Linear Vertical Nail Plate Streak: Case Report and Literature Review of Candida-Associated Longitudinal Melanonychia Striata

Contact Info

Product

Resources

About