Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: A pilot study

Jham, Bruno Correia; França, Esdras Campos; Oliveira, Ricardo Reis; Santos, Vagner Rodrigues; Kowalski, Luiz Paulo; Freire, Addah Regina da Silva

doi:10.1016/j.tripleo.2006.02.005

Cited by 52 publications

(79 citation statements)

References 17 publications

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“…Patients presenting the highest populations of these yeasts prior to RT are also the first to develop clinically detectable infection 7,20 , which reinforces the need for antifungal preventive approach for oral candidiasis in irradiated patients 20,21 . On the other hand, as opportunistic pathogens, the high prevalence and populations of fungi also reflect the poor conditions of oral hygiene and deterioration along the RT 34 , as well nutritional deficiencies and loss of weight in irradiated patients.…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 85%

“…Mucositis is associated with ulcerated areas, hinder nutrition and might facilitate the deployment of local or systemic infections 5 , usually caused by opportunistic microorganisms, such as enteric pathogens, anaerobic Gramnegative rods and yeasts 7,19,20,41,42 sometimes already present in higher proportions in cancer patients before RT 23 . The presence, severity and persistence of xerostomia seem to be the main factors associated with the presence of candidiasis in irradiated patients, facilitating the colonization of surfaces that previously did not harbor these fungi, allowing the growth of yeast populations 43,44 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…The occurrence of Candida sp. varies from 20 to 70% in patients undergoing RT, and some studies suggest that other species besides C. albicans are more favored in the irradiated patients 7,45 . However, literature has failed to discover any advantage for non-albicans Candida during or after RT 23,34,44,46,47 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…Individuals undergoing RT, often report the occurrence of inflammation of mucosa (mucositis), xerostomia, dysphagia, dysgeusia and candidiasis, particularly in patients who have not received previous dental treatment before RT [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review AbstractThe occurrence and severity of mucositis are the main complaints of patients with head and neck cancer submitted to radiotherapy (RT). This condition appears to be associated with changes in the oral microbiota and other side effects of RT, such as xerostomia and candidiasis. The aim of this study was to evaluate the effect of RT on the oral microbiota and its impact on radioinduced mucositis through literature review. Descriptors were selected for the collection of information in different databases, especially SciELO, BIREME, LILACS and PubMed. It was decided to consider only articles published since 1985. The descriptors radiotherapy, mucositis, dental caries, xerostomia, head and neck neoplasms and health promotion were used. It was selected 91 articles specifically discussing the microbiological aspects of mucositis, dental caries, oral candidiasis and microbial effects on the oral health of cancer patients, and 59 were included in the review. It was observed that microbial contamination is a secondary phenomenon capable of exacerbate the inflammation induced by the interaction of the radiation with the oral tissues, aggravating mucositis mainly in patients who present precarious conditions of oral hygiene, which reinforces the role of preventive dentistry in the follow up of the irradiated patient. Descriptors: Radiotherapy; Mucositis; Dental Caries; Xerostomia; Head And Neck Neoplasms; Health Promotion. ResumoA ocorrência e a severidade da mucosite constituem as principais queixas dos pacientes com câncer de cabeça e pescoço submetidos à radioterapia (RT). Essa condição parece estar associada às modificações da microbiota bucal e aos demais efeitos colaterais da RT, como xerostomia e a candidíase. O presente trabalho de revisão da literatura teve como objetivo avaliar o efeito que a RT exerce sobre a microbiota bucal e seu impacto na mucosite radioinduzida através de revisão de literatura. Foram selecionados os descritores para a coleta de informações em diferentes bancos de dados, destacando-se SciELO, BIREME, LILACS e PubMed. Decidiu-se considerar apenas artigos publicados desde 1985. Utilizou-se como descritores os termos radioterapia, mucosite, cárie dentária, xerostomia, neoplasias de cabeça e pescoço e promoção da saúde. Foram selecionados 91 artigos que discutiam especificamente os aspectos microbiológicos da mucosite, cárie dentária, candidíase oral e efeitos microbianos na saúde bucal de pacientes oncológicos e 59 foram incluídos na revisão. Observou-se que a contaminação microbiana é fenômeno secundário capaz de agravar a inflamação induzida pela interação da radiação com os tecidos bucais, agravando-se, principalmente, em pacientes que apresentam condições precárias de higiene bucal, o que reforça o papel da odontologia preventiva no acompanhamento do paciente irradiado. Descritores: Radioterapia; Mucosite; Cárie Dentária; Xerostomia; Neoplasias de Cabeça e Pescoço; Promoção da...

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Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 85%

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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show abstract

“…4 Several other mechanisms are also proposed for increasing of antifungal resistance when the yeasts are in biofilm form such as: altered growth; presence of extracellular matrix with delayed penetration of the antimicrobial agent; expression of resistance genes and presence of persisters cells. 5,6 The planktonic cell form is rarely found in human tissue, they are generally found in biofilm form in tissue, mucosal, implants, catheters and other surfaces, though. 7 Besides, it has recently been shown that the cells that detach from the biofilm have a greater association with mortality than equivalent planktonic yeasts.…”

Section: Introdutionmentioning

confidence: 99%

Biofilm Antifungal Susceptibility of Candida Urine Isolated from Ambulatory Patients

Becker¹,

Bulle²,

Rodrigues³

et al. 2016

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. Justificativa e Objetivos: A associação entre a formação de biofilme e resistência antifúngica foi sugerida por ser um fator importante na patogênese de diversas espécies de Candida. Além disso, estudos têm incluído candidíase invasiva de pacientes hospitalizados; no entanto, existem poucos estudos que avaliaram a distribuição das espécies, suscetibilidade aos antifúngicos e formação de biofilme de espécies de Candida isoladas de pacientes ambulatoriais. Assim, o objetivo deste estudo foi avaliar se a produção de biofilme contribui para a resistência antifúngica em Candida isoladas de amostras de urina obtidas de pacientes de ambulatório. (1/9) de C. tropicalis foram resistentes cetoconazol e foram anidulafungina (ANI) não-suscetíveis. Conclusão: MétodosNossos resultados mostraram a alta capacidade de formação de biofilme entre espécies de Candida isoladas de pacientes ambulatoriais.Background and Objectives: the association between the biofilm formations an antifungal resistance has

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A systematic review of oral fungal infections in patients receiving cancer therapy

Lalla

Latortue

Hong

et al. 2010

Support Care Cancer

220

179

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Purpose-The aims of this systematic review were to determine, in patients receiving cancer therapy, the prevalence of clinical oral fungal infection and fungal colonization, to determine the impact on quality of life and cost of care, and to review current management strategies for oral fungal infections.Methods-Thirty-nine articles that met the inclusion/exclusion criteria were independently reviewed by two calibrated reviewers, each using a standard form. Information was extracted on a number of variables, including study design, study population, sample size, interventions, blinding, outcome measures, methods, results, and conclusions for each article. Areas of discrepancy between the two reviews were resolved by consensus. Studies were weighted as to the quality of the study design, and recommendations were based on the relative strength of each paper. Statistical analyses were performed to determine the weighted prevalence of clinical oral fungal infection and fungal colonization.Results-For all cancer treatments, the weighted prevalence of clinical oral fungal infection was found to be 7.5% pretreatment, 39.1% during treatment, and 32.6% after the end of cancer therapy. Head and neck radiotherapy and chemotherapy were each independently associated with a significantly increased risk for oral fungal infection. For all cancer treatments, the prevalence of oral colonization with fungal organisms was 48.2% before treatment, 72.2% during treatment, and 70.1% after treatment. The prophylactic use of fluconazole during cancer therapy resulted in a prevalence of clinical fungal infection of 1.9%. No information specific to oral fungal infections was found on quality of life or cost of care.Conclusions-There is an increased risk of clinically significant oral fungal infection during cancer therapy. Systemic antifungals are effective in the prevention of clinical oral fungal infection in patients receiving cancer therapy. Currently available topical antifungal agents are less efficacious, suggesting a need for better topical agents.

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Candida oral colonization and infection in Brazilian patients undergoing head and neck radiotherapy: A pilot study

Cited by 52 publications

References 17 publications

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Biofilm Antifungal Susceptibility of Candida Urine Isolated from Ambulatory Patients

A systematic review of oral fungal infections in patients receiving cancer therapy

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