Candida infective endocarditis

Baddley, John W.; Benjamin, Daniel K.; Patel, Mukesh; Miró, José M.; Athan, Eugene; Baršić, Bruno; Bouza, Emilio; Clara, Liliana; Elliott, Tom; Kanafani, Zeina A.; Klein, John L.; Lerakis, Stamatios; Levine, Diane; Spelman, Denis; Rubinstein, Ethan; Tornos, Pilar; Morris, Arthur J.; Pappas, Peter G.; Fowler, Vance G.; Chu, Vivian H.; Cabell, Christopher H.

doi:10.1007/s10096-008-0466-x

Cited by 181 publications

(126 citation statements)

References 21 publications

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“…Higher mortality rates have been noted in these cases [2], with development of large vegetations and subsequent increased risk for septic emboli and unique skin lesions (according to the fungi isolated). Their clinical characteristics are similar to bacterial infective endocarditis and that is why modified Duke criteria still apply for its diagnostic approach [1].…”

Section: Discussionmentioning

confidence: 98%

“…Fungi comprise less than 2% of all cases of infective endocarditis [1,2,9] with Candida spp. representing 50-80% of them and C. albicans being the most commonly isolated species (30-40%).…”

Section: Discussionmentioning

confidence: 99%

“…Predisposing risk factors for fungal endocarditis include recent healthcare exposure, use of broad spectrum antibiotics, use of short-term indwelling catheters, prosthetic heart valves and intravenous drug users (IVDUs) [1,2,5]. Higher mortality rates have been noted in these cases [2], with development of large vegetations and subsequent increased risk for septic emboli and unique skin lesions (according to the fungi isolated).…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors include the presence of prosthetic valves, short term indwelling catheters, broad spectrum antibiotic use, history of health associated care and intravenous drug use [1,2]. A distinct clinical syndrome of disseminated candidiasis in heroin abusers exists [3] and it is associated with the use of lemon in the preparation of heroin prior to injection [4].…”

Section: Introductionmentioning

confidence: 99%

“…Manifestations include development of lesions in the skin of hair bearing areas such as the scalp, the beard, and the axillary and pubic areas where pustules are formed in the location of follicles, ocular lesions such as episcleritis and chorioretinitis, and lesions in bone and costal cartilage [3]. Candida endocarditis complicates candidaemia in up to 17.7% of patients [5] and is associated with a mortality rate of 30.3%, nearly double of that of bacterial infective endocarditis [2].…”

Section: Introductionmentioning

confidence: 99%

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Heroin with a Twist: Candida Glabrata Endocarditis Concurrent with Brain Mycetomas in an IV Drug User

Panos¹

2017

JMEN

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A 47-year-old male, with a history of IV drug use and usage of fresh lemon juice in the preparation of heroin doses, with hepatitis B and hepatitis C, presented with fever, dyspnea and a new found cardiac murmur at the apex. Echocardiography showed large vegetations on both leaflets of the mitral valve. After blood cultures were drawn an empiric antibiotic regimen was initiated. The mitral valve was successfully replaced surgically. Twenty-four hours post surgically the patient was extubated and was found to be suffering from left hemiplegia. Brain CT scan showed diffused sites of hemorrhage of the brain parenchyma, compatible with septic emboli that had underwent a hemorrhagic conversion. As mycetomas were considered in the differential diagnosis of these lesions, new blood cultures were drawn with an emphasis on the isolation of fungi, as this correlates with the use of lemon juice in the preparation of heroin doses, while the treatment regimen was modified to include an echinocandin to cover extensively for Candida spp. Two sets of blood cultures were positive for Candida glabrata. The patient responded well to the treatment administered and regained a significant amount of mobility.

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Section: Discussionmentioning

confidence: 98%

“…Fungi comprise less than 2% of all cases of infective endocarditis [1,2,9] with Candida spp. representing 50-80% of them and C. albicans being the most commonly isolated species (30-40%).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heroin with a Twist: Candida Glabrata Endocarditis Concurrent with Brain Mycetomas in an IV Drug User

Panos¹

2017

JMEN

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Infective Endocarditis

Mumtaz

Danziger‐Isakov

Mavroudis

et al. 2012

Pediatric Cardiac Surgery

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Infective Endocarditis

and¹,

Malani²

2013

Inpatient Cardiovascular Medicine

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Infective endocarditis (IE) is a rare, life-threatening disease that has long-lasting effects even among patients who survive and are cured. IE disproportionately affects those with underlying structural heart disease and is increasingly associated with healthcare contact, particularly in patients who have intravascular prosthetic material. In the setting of bacteraemia with a pathogenic organism, an infected vegetation may form as the end result of complex interactions between invading microorganisms and the host immune system. Once established, IE can involve almost any organ system in the body. The diagnosis of IE may be difficult to establish and a strategy that HHS Public Access ToC blurbInfective endocarditis (IE) is caused by damage to the endocardium of the heart followed by microbial, usually bacterial, colonization. IE is a multisystem disease that can be fatal if left untreated and antimicrobial prophylaxis strategies for IE remain controversial.

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Candida infective endocarditis

Abstract: Purpose-Candida infective endocarditis (IE) is uncommon but often fatal. Most epidemiologic data are derived from small case series or case reports. This study was conducted to explore epidemiology, treatment patterns, and outcomes of patients with Candida IE.

Cited by 181 publications

References 21 publications

Heroin with a Twist: Candida Glabrata Endocarditis Concurrent with Brain Mycetomas in an IV Drug User

Heroin with a Twist: Candida Glabrata Endocarditis Concurrent with Brain Mycetomas in an IV Drug User

Infective Endocarditis

Infective Endocarditis

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