Candida G lab rata Chorioamnionitis Following In Vitro Fertilization and Embryo Transfer

Abstract

Candida glabrata is a yeast which is considered to be a commensal of the vagina with limited pathogenicity in the immunocompetent host. We report 2 cases of severe chorioamnionitis occurring in pregnancies achieved by in vitro fertilization techniques which resulted in preterm delivery and pregnancy loss. Candida glabrata as the causative agent was probably introduced into the uterus by the cannula at the time of embryo transfer. It is recommended that appropriate investigation of the microbial flora of the cervix be undertaken and treatment instituted prior to embryo transfer in order to prevent this complication.

Candida glabrata Sepsis in an Immunocompetent Individual: A Case Report

“…glabrata infection has also been reported as a cause of chorioamnionitis in healthy pregnant women [6][7][8]. The majority of cases appear to be reported in the IVF population and present at 15-24 weeks gestation.…”

“…The majority of cases appear to be reported in the IVF population and present at 15-24 weeks gestation. The authors propose that the possible source of infection is the lower genital tract, with introduction of organisms into the uterus at time of embryo transfer [6][7][8]. In the non-IVF population, C. glabrata chorioamnionitis has been associated with foreign bodies (cerclage and intrauterine devices) and immunosuppression (untreated gestational diabetes) [6].…”

Candida glabrata complicating in vitro pregnancy: successful management of subsequent pregnancy

“…Heretofore, little information was available to guide providers. Sfameni et al (4) reported two cases of C. glabrata causing chorioamnionitis within the setting of IVF. With the first case, the investigators reported their experience with a subsequent embryo transfer.…”

Chorioamniotite à Candida glabrata après fécondation in vitro

“…Nous avons retrouvé 12 cas publiés de chorioamniotite à C. glabrata en effectuant une recherche sur Pubmed avec les mots clés Candida glabrata et pregnancy (Tableau 1) [6][7][8][9][10][11][12][13][14]. Sept cas sont survenus à la suite d'une FIV [6][7][8]11] (Tableau 1). Si les facteurs de risques décrits semblent classiques en dehors des cas avec FIV (cerclage, diabète non traité, drépanocytose, ventilation maternelle et cathéter central), les cas décrits sur des FIV sont le plus souvent isolés associés dans trois cas à des ruptures des membranes dont il est difficile de distinguer s'il s'agit d'un facteur de risque ou d'un symptôme de la chorioamniotite à bas bruit.…”