Candida auris Blood stream infection- a descriptive study from Qatar

Koleri, Junais; Petkar, Hawabibee Mahir; Soub, Hussam Abdel Rahman S. Al; Almaslamani, Muna

doi:10.1186/s12879-023-08477-5

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Herein, we report the first case of C. auris identified in Jordan through the national HAI and AMR surveillance program in Jordan. This adds Jordan to the eight other countries in the Middle East Region that have reported C. auris cases (Oman, Kuwait, Saudi Arabia, the United Arab Emirates, Iran, Sudan, Lebanon and Qatar) [6,[12][13][14].…”

Section: Discussionmentioning

confidence: 92%

Report of the First Case of Candida auris Identified in Jordan

Al-Ramahi,

Ghanem,

Sayyouh

et al. 2023

Microbiology Research

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Candida auris (C. auris) is an opportunistic budding yeast that has been identified across 41 countries, including several countries in the Middle East. The increasing global concern stems from the pathogen’s acquired resistance to antifungal drugs and its ability to form biofilms, which allows it to survive on hospital surfaces and medical devices for up to 14 days, compromising infection prevention measures in hospitals. In this report, we present the first (reported) case of C. auris isolated from a urine sample from a 48-year-old female living in Jordan. The patient succumbed to illness five days following admission to hospital. The isolate was identified retrospectively through the national surveillance system in Jordan and was confirmed by real-time PCR. Antifungal susceptibility was carried out using the microbroth dilution technique and the isolate was found to be susceptible to all tested antifungal drugs. Overall, the report emphasizes the need for active surveillance for the rapid identification of high-risk patients colonized with C. auris. It also stresses the importance of understanding the inter-clade difference in the susceptibility pattern of C. auris to facilitate the development of preventive and therapeutic strategies.

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Section: Discussionmentioning

confidence: 92%

Report of the First Case of Candida auris Identified in Jordan

Al-Ramahi,

Ghanem,

Sayyouh

et al. 2023

Microbiology Research

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“…Following being established in the healthcare facility, pandemic progression and associated critical care patients exposed to all highlighted risk factors contributed to this noticeable shift of epidemiology. To support that assumption, when a retrospective study of 36 cases of Candida auris fungemia was reviewed between 2018-2021, crossing the pandemic course, the majority occurred in patients who acquired long-term complications following primary COVID infection [32].…”

Section: Discussionmentioning

confidence: 99%

Trends in Bacterial and Candida Infections Prior to and Throughout the COVID-19 Pandemic

Mana,

Wilson,

Hadi

et al. 2023

Preprint

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Introduction: The COVID-19 pandemic caused by SARS-CoV-2 virus resulted in significant global health consequences. The interventions introduced to limit the spread of the virus had a significant impact on the course of the pandemic but also might involve other pathogens besides SARS-CoV-2. This study investigates the epidemiological variations for major bacterial and common fungal pathogens represented by Candidaspecies infection in Qatar through retrospective hospital records. Methods: Retrospective data was collected on all bacterial and Candida infections from Hamad General Hospital between January 2019-December, 2021. Statistical analyses were performed using R (Version 4.1.0). Infection count comparisons were performed using chi-square goodness of fit tests. Differences in patient numbers were tested with one-way ANOVA followed by post-hoc Tukey HSD. The number of infections and measures were correlated using Spearman rank correlation. The significance level was set at 0.05, and where applicable, the Holm-Bonferroni method was used to correct for multiple testing. Results: The general trend for bacterial and Candida infections showed a significant decrease (p < 0.05) following the imposed restrictions and increases during restriction lifting periods. The number of bacterial infections correlated with the number of international visitors (r= 0.61, p <0.01), while the number of Candida infections correlated with hospital admissions of COVID-19 patients (r=0.59, p = 0.013). Conclusions: The results provide a general overview of the infection trends in Qatar through the COVID-19 pandemic and illustrate some of the pandemic interventions' effects on bacterial and Candida infections. However, further research is needed to understand underlying trend dynamics better.

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“…In Tunisia, resistance to fluconazole was observed in 63 % and 16% of C. albicans and C. glabrata isolates from vaginal swab samples of pregnant women, respectively [ 45 ]. Moreover, numerous sporadic cases and outbreaks caused by C. auris have been recently reported in the MENA region, including Lebanon [ 27 , 29 , 30 , 46 , 47 , 48 ]. Other reports on Aspergillus showed differing frequency of azole resistance as follows: 31.5% were resistant in Lebanon [ 24 ], 30.6% were resistant in Iran [ 49 ], 3.3–25% were resistant in Turkey [ 50 , 51 , 52 ], 4.1% were resistant in Tunisia [ 53 ], 2.9% were resistant in Qatar [ 54 ], and 0% were resistant in Kuwait [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Use and Resistance in a Lower–Middle-Income Country: The Case of Lebanon

Hassoun,

Kassem,

Hamze

et al. 2023

Antibiotics

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Antimicrobial resistance is a serious threat, particularly in low- and middle-income countries (LMICs). Antifungal resistance is often underestimated in both healthcare and non-clinical settings. In LMICs, it is believed that the inappropriate use of antifungals, limited surveillance systems, and low diagnostic capacities are significant drivers of resistance. Like other LMICs, Lebanon lacks antifungal use and resistance surveillance programs, and the impact of antifungal resistance in the country remains unclear, especially during the unfolding economic crisis that has severely affected medical care and access to safe food and water. Interestingly, the widespread use of antifungals in medicine and agriculture has raised concerns about the development of antifungal resistance in Lebanon. In this light, we aimed to survey available antifungal drugs in the country and evaluate susceptibility patterns of prevalent fungal species to guide empiric treatments and develop antifungal stewardship programs in Lebanon. We noted that the economic crisis resulted in significant increases in antifungal drug prices. Additionally, a comprehensive literature search across PubMed, ScienceDirect, and Google Scholar databases identified 15 studies on fungal infections and antifungal resistance conducted from 1998 to 2023 in Lebanon. While data on antifungal resistance are limited, 87% of available studies in Lebanon focused on candidiasis, while the remaining 13% were on aspergillosis. Overall, we observed a marked antimicrobial resistance among Candida and Aspergillus species. Additionally, incidences of Candida auris infections have increased in Lebanese hospitals during the COVID-19 pandemic, with a uniform resistance to fluconazole and amphotericin-B. Taken together, a One Health approach, reliable diagnostics, and prudent antifungal use are required to control the spread of resistant fungal pathogens in healthcare and agricultural settings.

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Candida auris Blood stream infection- a descriptive study from Qatar

Cited by 10 publications

References 42 publications

Report of the First Case of Candida auris Identified in Jordan

Report of the First Case of Candida auris Identified in Jordan

Trends in Bacterial and Candida Infections Prior to and Throughout the COVID-19 Pandemic

Antifungal Use and Resistance in a Lower–Middle-Income Country: The Case of Lebanon

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