Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease

Zeng, Su-Ling; Rosati, Elisa; Saggau, Carina; Messner, Berith; Chu, Huikuan; Duan, Yi; Hartmann, Phillipp; Wang, Yanhan; Ma, Shengyun; Huang, Wendy; Lee, Jihyung; Lee, Sung Min; Carvalho-Gontijo, Raquel; Zhang, Vivian; Hoffmann, Joseph P.; Kolls, Jay K.; Brenner, David A.; Kisseleva, Tatiana; LeibundGut‐Landmann, Salomé; Bächer, Petra; Stärkel, Peter; Schnabl, Bernd

doi:10.1016/j.chom.2023.02.001

Cited by 27 publications

(9 citation statements)

References 49 publications

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“…The gut mycobiome contributes to ALD. C. albicans-specific Th17-cells migrate from the intestine to the liver and contribute to ethanol-induced liver disease in mice [42]. Candida albicans secrete the exotoxin candidalysin, which can cause damage to the hepatocytes and increases ethanol-induced liver disease in mice [43,44] (Fig.…”

Section: Alcohol-associated Liver Diseasementioning

confidence: 99%

The role of the microbiome in liver disease

Schöler,

Schnabl

2024

Current Opinion in Gastroenterology

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Purpose of review The intestinal microbiome and the gut-liver axis play a major role in health and disease. The human gut harbors trillions of microbes and a disruption of the gut homeostasis can contribute to liver disease. In this review, the progress in the field within the last 3 years is summarized, focusing on metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), autoimmune liver disease (AILD), and hepatocellular carcinoma (HCC). Recent findings Changes in the fecal virome and fungal mycobiome have been described in patients with various liver diseases. Several microbial derived metabolites including endogenous ethanol produced by bacteria, have been mechanistically linked to liver disease such as MASLD. Virulence factors encoded by gut bacteria contribute to ALD, AILD and HCC. Novel therapeutic approaches focused on the microbiome including phages, pre- and postbiotics have been successfully used in preclinical models. Fecal microbiota transplantation has been effective in attenuating liver disease. Probiotics are safe in patients with alcohol-associated hepatitis and improve liver disease and alcohol addiction. Summary The gut–liver axis plays a key role in the pathophysiology of liver diseases. Understanding the microbiota in liver disease can help to develop precise microbiota centered therapies.

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Section: Alcohol-associated Liver Diseasementioning

confidence: 99%

The role of the microbiome in liver disease

Schöler,

Schnabl

2024

Current Opinion in Gastroenterology

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“…Recently, the possible link between liver disease and C. albicans has been taken into consideration, and mechanisms explored include translocation of β-glucan, 126 Th17 cells, 127 and candidalysin 128 derived from or secreted by intestinal albicans, as well as the activation of Dectin-1 in Kupffer cells, and subsequent increase in IL-1β expression. 129 Nevertheless, still little is known about whether gut fungi count in HCC, although some bacterial species are found to be correlated.…”

Section: Specific Fungi In Oncogenesismentioning

confidence: 99%

Unveiling the hidden players: exploring the role of gut mycobiome in cancer development and treatment dynamics

Li,

Huang,

Chen

2024

Gut Microbes

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The role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic fungi in cancer biological process, including oncogenesis, progression, and treatment response. Mechanisms explored include fungal influence on host immunity, secretion of bioactive toxins/metabolites, interaction with bacterial commensals, and migration to other tissues in certain types of cancers. Attempts to utilize fungal molecular signatures for cancer diagnosis and fungal-derived products for treatment are discussed. A few studies highlight fungi’s impact on the responsiveness and sensitivity to chemotherapy, radiotherapy, immunotherapy, and fecal microbiota transplant. Given the limited understanding and techniques in fungal research, the studies on gut fungi are still facing great challenges, despite having great potentials.

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“… 109 In addition, alcohol uptake affects immune cell activity in a manner that contributes to hepatic inflammation. 110 , 111 There are in vitro data to suggest that defective efferocytosis by hepatic macrophages may contribute to liver injury in ALD. For example, exposure of macrophages to ethanol impaired their ability to engulf dead cells.…”

Section: Efferocytosis In Liver Diseases ( Fig 2 )mentioning

confidence: 99%

Efferocytosis in liver disease

Shi,

Moore,

Wang

et al. 2024

JHEP Reports

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Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease

Cited by 27 publications

References 49 publications

The role of the microbiome in liver disease

The role of the microbiome in liver disease

Unveiling the hidden players: exploring the role of gut mycobiome in cancer development and treatment dynamics

Efferocytosis in liver disease

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