Candida albicans osteomyelitis in an infant

Pan, Nancy; Herzog, Ronit; Blanco, John S.; Nauseef, William M.; Jenkins, Stephen G.; Kovanlıkaya, Arzu; Salvatore, Christine M.; Toussi, Sima S.

doi:10.1097/bpb.0b013e3283613313

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…Fluconazole inhibits the demethylation of C-14 sterols, accumulates abnormal methyl sterols, increases cellular permeability, and has inhibitory action against fungal cells [11]. In their case report, Pan et al also preferred fluconazole to treat candidal osteomyelitis in pediatric patients, which has shown promising outcomes [12].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Fungal Osteomyelitis of the Distal Tibia in a Pediatric Patient

Afaque,

Agrawal,

Shankhwar

et al. 2024

Cureus

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Staphylococcus aureus infection is the most common cause of osteomyelitis. Over 100,000 fungal species have been described; only 150 are pathogenic to humans. These opportunistic infections frequently enter the body due to a decrease in host defense or through an invasive gateway, such as a dental extraction or skin discontinuity due to trauma. Symptoms and radiological examination often mimic those of other etiologies, which can lead to substantial delays in treatment. Our case is a 13-year-old healthy boy with no history of immune incompetency who presented to us with complaints of pain and swelling over his left ankle and leg with an on-and-off history of fever for 15 days. Based on his history and examination, he is diagnosed as having sub-acute osteomyelitis of the distal tibia with septic arthritis. The bacterial culture has no growth; however, the potassium hydroxide mount came positive for fungal elements having hyphae and pseudohyphae, and the fungal culture came positive for Candida. Management of fungal infections is challenging as they have infrequent involvement in bones. Fungal osteomyelitis is considered a rare entity in the literature, and the current case is studied for the management and diagnosis of a rare variant of osteomyelitis in the pediatric population. The treatment guidelines vary based on the identified organism and the duration of treatment. Debridement of fungal osteomyelitis or septic arthritis includes removing sinus tracts, evaluation for squamous cell carcinoma, bony and soft-tissue debridement, and antibiotic or antifungal bead placement. The spectrum of osteomyelitis ranges from Staphylococcus aureus organisms to tumors; therefore, it is necessary to investigate every spectrum of the disease, and fungal infections should be considered differential even though they are a rare entity. Early diagnosis, surgical debridement, and proper antifungal treatment based on fungal species lead to better clinical outcomes and results.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Fungal Osteomyelitis of the Distal Tibia in a Pediatric Patient

Afaque,

Agrawal,

Shankhwar

et al. 2024

Cureus

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“…However, it is resistant to many antibiotics and disinfectants, which makes it a difficult pathogen to treat. Candida albicans ( C. albicans ) can cause diseases such as cutaneous candidiasis, mucosal candidiasis, visceral and central nervous system candidiasis, pneumonia, gastroenteritis, endocarditis, osteomyelitis, and septicemia, so it has been recognized as an increasingly important human pathogen …”

Section: Introductionmentioning

confidence: 99%

Comparison of antimicrobial activities of polyacrylonitrile fibers modified with quaternary phosphonium salts having different alkyl chain lengths

Chang

Wang

Tong

et al. 2016

J of Applied Polymer Sci

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A series of polyacrylonitrile fibers (PANF) modified with quaternary phosphonium salts having various alkyl chain lengths (C 1 , C 2 , C 6 , C 8 , C 12 ) were synthesized and compared for their antimicrobial activities by the improved shake flask method. The asprepared fibers were named MTPB-PANF, ETPB-PANF, HTPB-PANF, OTPB-PANF, and DTPB-PANF, respectively. The representative microorganisms employed were Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Candida albicans (C. albicans). Results from the current study showed that the alkyl chain length of quaternary phosphonium salts not only affected the synthesis of the fibers, but also impacted their antimicrobial activities. There was a rule that the longer the alkyl chain length, the more easily the quaternary phosphonium salts modify the fibers and the better the antimicrobial activities of the modified fibers. All the modified fibers exhibited good broad-spectrum antimicrobial activities. Specifically, DTPB-PANF exhibited an outstandingly high antimicrobial activity, which was nearly unaffected by the environmental pH (3-10). It can kill all the four pathogens in 15 min and had an excellent wash-resistant property.

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Bacterial infections of the bones and joints

Cassat

2025

Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant

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Candida albicans osteomyelitis in an infant

Cited by 8 publications

References 25 publications

A Rare Case of Fungal Osteomyelitis of the Distal Tibia in a Pediatric Patient

A Rare Case of Fungal Osteomyelitis of the Distal Tibia in a Pediatric Patient

Comparison of antimicrobial activities of polyacrylonitrile fibers modified with quaternary phosphonium salts having different alkyl chain lengths

Bacterial infections of the bones and joints

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