Candesartan plus hydrochlorothiazide: an overview of its use and efficacy

Mugellini, Amedeo; Nieswandt, Valentina

doi:10.1517/14656566.2012.745511

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…HCT is also used to lower blood pressure while walking, which is mostly caused by a drop in blood pressure at night [ 5 ]. In clinical trials lasting anywhere from 8 weeks to 3 years, the fixed-dose combination medication candesartan and hydrochlorothiazide has emerged as a key option in the treatment of hypertension due to its great efficacy in lowering blood pressure and preventing damage to target organs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Ali

2023

Journal of Analytical Methods in Chemistry

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Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both medicines in real pharmaceutical formulations. A new calibration approach was implemented based on chemical H-point standards. This approach was developed to resolve significantly overlapping spectra of two analytes and provide direct correction of both proportional and constant errors caused by the matrix of the sample. The first method of simultaneous determination of candesartan cilexetil and hydrochlorothiazide was carried out using the H-point standard addition method at wavelengths 239 and 283. For the ratio of the absorption at two selected wavelengths, one of which is the isoabsorptive point and the other being the maximum of one of the two components, the second method absorption ratio method was utilized. In distilled water, the isoabsorptive point of candesartan cilexetil and hydrochlorothiazide occurs at 258 nm. λmax of hydrochlorothiazide is 273 nm, which is the second wavelength used. Lastly, the absorbance correction method was implemented. This approach is based on absorbance correction equations and uses distilled water as the solvent for the examination of both medicines. In NaOH/EtOH solvent, the absorbance maxima of candesartan cilexetil and hydrochlorothiazide are 250 nm and 340 nm, respectively. For both wavelengths, candesartan cilexetil and hydrochlorothiazide exhibited linearity over a concentration range of 1–46 μg/ml and 1–44 μg/ml, respectively, for H-point standard addition. The Q-absorption ratio approach provides linearity over the concentration ranges of 1–46 μg/ml at 273 nm for candesartan cilexetil and 1–29 μg/ml for hydrochlorothiazide, 1–46 μg/ml at 258 nm for candesartan cilexetil, and 1–44 μg/ml for hydrochlorothiazide. For hydrochlorothiazide, the linearity for the correction absorbance method was obtained throughout a concentration range of 1–46 μg/ml at wavelengths 250 and 340 nm and 1–44 μg/ml at wavelength 250 nm. The results of the analysis have been statistically and empirically supported by recovery studies. All methods yielded recoveries in the range of 96 ̶102% for both medications. The LOD ranged from 0.46 ̶0.94 μg/mL for hydrochlorothiazide and from 1.26 ̶2.40 μg/mL for candesartan cilexetil. The approaches were then used to quantify candesartan cilexetil and hydrochlorothiazide in pharmaceutical tablets.

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Section: Introductionmentioning

confidence: 99%

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Ali

2023

Journal of Analytical Methods in Chemistry

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“…For example, the first SPC of an angiotensin receptor blocker (ARB) and a CCB was valsartan plus amlodipine which, apart from achieving better efficacy than each component, was also shown to significantly decrease the risk of edema, a frequent side-effect of dihydropyridine CCBs8. Similarly, olmesartan has been combined with either amlodipine or hydrochlorothiazide in SPCs9, as is the case with telmisartan10,11, losartan12,13, irbesartan14–16, candesartan17,18 and aliskiren (a direct renin antagonist)2,3,19.…”

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confidence: 99%

Single-pill combinations: a therapeutic option or necessity for vascular risk treatment?

Katsiki

Athyros

Karagiannis

2013

Journal of Drug Assessment

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Candesartan Cilexetil 32 mg/Hydrochlorothiazide 25 mg in Unselected Patients with High or Very High Cardiovascular Risk: Efficacy, Safety, and Metabolic Impact

2014

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Candesartan plus hydrochlorothiazide: an overview of its use and efficacy

Abstract: The fixed-dose combination drug candesartan/hydrochlorothiazide turned out to be a significant alternative in the treatment of hypertension, both for its high efficacy in BP reduction and in prevention of target organ damage, both for its tolerability and patient compliance.

Cited by 5 publications

References 56 publications

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Single-pill combinations: a therapeutic option or necessity for vascular risk treatment?

Candesartan Cilexetil 32 mg/Hydrochlorothiazide 25 mg in Unselected Patients with High or Very High Cardiovascular Risk: Efficacy, Safety, and Metabolic Impact

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