Cancers of unknown primary

Tay, Jessica; Dewdney, Alice

doi:10.12968/hmed.2019.80.5.c70

Cited by 2 publications

(2 citation statements)

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“…Cancers of unknown primary (CUP) is defined as a metastatic malignant tumor confirmed by histopathology, but its primary sites cannot be identified in the initial treatment and further evaluation. [ 5 , 6 ] The clinical characteristics of heterogeneous tumors in this group varied and the prognosis was poor. Their common features are metastasis early, strong invasion, and unpredictable metastasis mode.…”

Section: Discussionmentioning

confidence: 99%

Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review

Zhu,

Li,

et al. 2023

Medicine

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Rationale: Cancer with unknown primary site is a kind of disease that is difficult to deal with clinically, accounting for 2% to 9% of all newly diagnosed cancer cases. Here, we report such a case with pelvic metastatic squamous cell carcinoma of an unknown primary site and review the relevant literature. Patient concerns & Diagnoses: A 43-year-old Chinese female patient was referred to our hospital and initially diagnosed as “malignant tumor of right adnexal area?, obstruction of right ureter, secondary hydronephrosis”. Interventions: Thereafter cytoreductive surgery was performed which included a total hysterectomy, left adnexectomy, partial omentum resection, pelvic lymph node dissection, and para-aortic lymph node dissection. The primary lesion could not be identified by supplementary examination and postoperative pathology. The patient was diagnosed as pelvic metastatic squamous cell carcinoma whose primary site was unknown. To prevent a recurrence, we administered adjuvant chemotherapy for the patient. Outcomes: The patient was followed up after treatment, complete remission has been maintained for 72 months, and no recurrence or metastasis has been found. Lessons: Our case demonstrates that surgery combined with chemotherapy could be helpful for pelvic metastatic squamous cell carcinoma of unknown primary site.

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Section: Discussionmentioning

confidence: 99%

Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review

Zhu,

Li,

et al. 2023

Medicine

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“…Therefore, International Guidelines tried to clarify the diagnostic management (5), highlighting the importance of patients' clinical and familiar history, and on risk factors such as cancer predisposition and occupational activity. A complete physical examination should be performed with accuracy for respiratory and abdominal systems which are the most common sites of primary cancers, according to the data reported in the follow-up and autopsy of CUPs' patients, without neglecting the clinical presentation that could drive the primary tumor research (6). The initial diagnostic work-up should include basic blood analyses and relevant tumor markers.…”

Section: Introductionmentioning

confidence: 99%

Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review

Parisi,

Gambardella,

Ruggiero

et al. 2024

Oncol Lett

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Cancers of unknown primary (CUPs) are a heterogeneous group of tumors characterized by a difficult diagnosis. The primitive tumor remains unknown, whereas metastases are the most common manifestation. Occult male breast cancers are very rare types of CUPs. The present study describes the case of a 64-year-old man affected by a CUP of presumed mammary origin. The aim of the article and the present review was to focus on their management. To the best of our knowledge, only thirteen cases have been reported in the literature. Because no specific guidelines are available, various approaches have been applied, influencing the treatment and the prognosis of patients with CUP.

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Cancers of unknown primary

Cited by 2 publications

References 10 publications

Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review

Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review

Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review

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