Cancers After Renal Transplantation in Tunisia: Multicenter Experience

Harzallah, Kais; Cherif, Mejda; Yaïch, S.; Skhiri, H.; Abderrahim, E.; Chareffedine, K.; Younsi, F. El; Abdallah, T. Ben; Hamida, J; Achour, A.; May, M. El; Manaa, J.; Hachicha, J.; Kheder, A.

doi:10.1097/00007890-201007272-01355

Cited by 5 publications

(9 citation statements)

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“…4,56,57 Sixteen of our reviewed studies identified incidences of KS in OTRs ( Table 2). 61 Several reports 58,62 from Middle Eastern organ transplant centers indicated high incidences of KS-an observation consistent with reports that the incidence of KS is much higher in Middle Eastern OTRs (5.3%) than in those from Western countries (including the United States) (0.5%). One study 60 reported that KS was the third most common de novo tumor in this patient population.…”

Section: Incidence and Risk Factors Of Skin Cancers In Otrssupporting

confidence: 78%

“…One study 60 reported that KS was the third most common de novo tumor in this patient population. 61 Areas of cutaneous diagnosis mostly included the upper and lower limbs, with legs being affected nearly twice as often as arms. 61 Several reports 58,62 from Middle Eastern organ transplant centers indicated high incidences of KS-an observation consistent with reports that the incidence of KS is much higher in Middle Eastern OTRs (5.3%) than in those from Western countries (including the United States) (0.5%).…”

Section: Incidence and Risk Factors Of Skin Cancers In Otrsmentioning

confidence: 99%

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Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

Mudigonda

Levender

O’Neill

et al. 2013

Dermatologic Surgery

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Sun education programs and frequent screenings in organ transplant clinics have provided the best preventative strategies after transplantation, although the characteristics of the immunosuppressive regimen also play an important role. Thus, the adjuvant strategy of modifying immunosuppression may be effective when confronting severe transplant-associated skin cancer. Although the decision-making process for curbing levels of immunosuppression is difficult, further long-term, randomized controlled studies should assess the effect of using less immunosuppressant medication while preserving graft function.

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Section: Incidence and Risk Factors Of Skin Cancers In Otrssupporting

confidence: 78%

Section: Incidence and Risk Factors Of Skin Cancers In Otrsmentioning

confidence: 99%

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

Mudigonda

Levender

O’Neill

et al. 2013

Dermatologic Surgery

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“…Kaposi's sarcoma is the commonest malignancy according to Turkish study where it constituted 32 % of all malignancies (Yilderim et al, 2006). Even higher relative frequency of this tumor (41.6%) has been reported in Tunisian study (Hazrallah et al, 2008). In our study, visceral involvement of Kaposi's sarcoma (7 patients; 63.6%) was more common than cutaneous involvement which occurred in 4 patients (27.2%).…”

Section: Discussionsupporting

confidence: 43%

Posttransplant Malignancies in Renal Transplant Recipients: 22-years Experience from a Single Center in Pakistan

Yunus

Aziz²,

Mubarak³

2012

Asian Pacific Journal of Cancer Prevention

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Objective: To study the incidence, types and distribution pattern of malignant tumors in renal transplant recipients at a single center in Pakistan. Materials and methods: This retrospective study was conducted at Sindh Institute of Urology and Transplantation (SIUT) and included all transplant patients on regular follow-up from November 1986 to December 2008. The original biopsy reports and case files of all patients who developed posttransplant malignancies were reviewed and relevant demographic, clinical, radiological, and histopathological data were retrieved and analyzed. SPSS version 10.0 was used for statistical analysis. Results: Over 22 years of study period, 1816 renal transplants were carried out at our center. Among these, 44 patients developed malignancies constituting an overall incidence rate of 2.4%. All patients in this study were males with a mean age of 34.9±9.5 years (range: 9 to 60 years). The most common type of malignancy was lymphoma (27 patients, 61.4%), followed by Kaposi's sarcoma (11 patients, 25%) and skin malignancies (3 patients, 6.8%). One case each of adenocarcinoma of the gallbladder, acute myeloid leukemia (AML), conjunctival carcinoma-in-situ and seminoma were also diagnosed. Conclusion: Posttransplant malignancies occurring in our renal transplant recipients show different incidence rates and patterns as compared with western studies.

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“…Dans une cohorte de 1844 patients, Serraino et al [7] constatent que le risque de SKPT est 113 fois plus élevé chez les transplantés rénaux. En Tunisie, dans l'étude multicentrique sur les tumeurs posttransplantation rénale portant sur 36 patients réalisée par Harzallah et al [8], le SKPT représente 41,6 % des tumeurs malignes retrouvées.…”

Section: Discussionunclassified

“…La substitution des inhibiteurs de la calcineurine par le sirolimus semble être une bonne alternative. Le sirolimus inhibe la progression du SKPT, tout en exerçant un effet antirejet [8,16,34,35].…”

Section: Traitement Médicalunclassified

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

Hasna

Slama

Sahtout

et al. 2013

Med Buccale Chir Buccale

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Résumé -Abstract -Oral Kaposi sarcoma after renal transplantation: a case report and review of literature. The immunosuppressive therapies are associated with an increase in the risk of Kaposi sarcoma among transplant patients. The management of these tumours is challenging as the immunosuppression must be monitored to prevent a potential transplant rejection. In 2009, a 48-year-old patient was referred to us by the nephrology department for a suspicious palatal lesion. The patient having had a renal transplantation in 2008 was under immunosuppressants. The intra-oral examination revealed a right red-purple palatal swelling, of 2.5 cm in long axis, painless, with firm consistency on palpation. The buccal vestibule was clear. No satellite adenopathy was observed. A biopsy revealed Kaposi sarcoma. An assessment of the local and general extension concluded an absence of an underlying osseous involvement as well as other remote locations. The treatment consisted of a modification of immunosuppressants associated with tumor resection surgery. The loss of mucous substance was repaired by an advanced vestibular flap and rotational palatal flap. The histology confirmed the diagnosis of Kaposi sarcoma and the limits of curative surgery. A 14-month follow-up showed a favorable evolution. Local and regional monitoring did not reveal any recurrence signs; this was confirmed by CTscan follow-up examination. Subsequently, the patient underwent a prosthetic restoration by means of a removable partial denture.

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Cancers After Renal Transplantation in Tunisia: Multicenter Experience

Cited by 5 publications

References 0 publications

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

Posttransplant Malignancies in Renal Transplant Recipients: 22-years Experience from a Single Center in Pakistan

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

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