Cancerous Cyst of the Tail of the Pancreas Simulating Carcinosarcoma

Hartz, Philip H.; Sar, A. Van Der

doi:10.1093/ajcp/16.3.219

Cited by 8 publications

(5 citation statements)

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“…Sarcomatoid carcinoma has also been described in the small intestine, 128 colon, 129 anus, 130 liver 131 , 132 and gall bladder 133 . In the pancreas, sarcomatoid carcinoma is well recognized with 4 distinct histological subtypes: spindle cell carcinoma, pleomorphic giant cell carcinoma, round cell anaplastic carcinoma and malignant giant cell tumour 134 , 135 …”

Section: Intra‐abdominal Sarcomasmentioning

confidence: 99%

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Al‐Nafussi

Wong

2001

Histopathology

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Intra-abdominal spindle cell lesions are uncommon and often present a diagnostic challenge. An important group of such lesions are the gastrointestinal stromal tumours. Other intra-abdominal spindle cell lesions include fibromatosis, various sarcomas-in particular, leiomyosarcoma, liposarcoma, and malignant peripheral nerve sheath tumour-and, in women, endometrial stromal sarcoma. Less common lesions are inflammatory myofibroblastic tumours, the mesenteric spindle cell reactive lesions, retroperitoneal fibrosis, and solitary fibrous tumour. A variety of intra-abdominal tumours of nonmesenchymal origin may have a spindle cell/sarcomatoid morphology; these include sarcomatoid carcinoma, malignant melanoma and, in women, sarcomatoid granulosa cell tumour. Finally, metastatic sarcomas from pelvic or extra-abdominal organs need also be considered. A set of practical aids to the diagnosis of intra-abdominal spindle cell lesions is presented to assist pathologists dealing with such lesions, particularly with regards to the consideration of differential diagnoses.

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Section: Intra‐abdominal Sarcomasmentioning

confidence: 99%

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Al‐Nafussi

Wong

2001

Histopathology

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“…Squamous differentiation and neuroendocrine differentiation have been described in ACP. Pancreatic neoplasms that are known to harbor focal areas with anaplastic carcinoma include mucinous neoplasms . Awareness of this possible differentiation and careful examination of similar cases is warranted to avoid missing an aggressive component …”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic neoplasms that are known to harbor focal areas with anaplastic carcinoma include mucinous neoplasms. 2,18,[28][29][30][31][32][33][34][35][36] An epithelial origin of both the anaplastic mononuclear cells and osteoclast-like giant cells has been proposed, based on positive staining for CEA and low molecular weight cytokeratin in both groups of cells. 7,[37][38][39][40] In addition a histiocytic origin has also been proven in osteoclastlike giant cells, through positive staining with CD68.…”

Section: Discussionmentioning

confidence: 99%

Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features

Hussein

Khader

2019

Diagnostic Cytopathology

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Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under the umbrella of classic PDAC. Here, we review the most up to date data that literature provides about ACP, to bring familiarity with this entity to the cytopathology practice, and to elucidate the role cytopathologists can play in recognizing and diagnosing this subtype on pancreatic aspiration biopsy, before surgical resection. We also describe a rare case of ACP, demonstrating signet ring cell features, that was diagnosed on fine needle aspiration of a pancreatic mass.

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“…3 To the best of our knowledge, however, only 13 cases of anaplastic carcinoma arising from MCN are reported in the English language literature. [12][13][14][15][16][17][18][19][20][21] The usual findings in the aspirates from MCN, albeit benign, include pools of mucin with aggregates of mucinous columnar epithelial cells arranged in sheets with honey-comb pattern. The nuclei are round or ovoid and may have small nucleoli.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Carcinoma Arising in a Mucinous Cystic Neoplasm Masquerading as Pancreatic Pseudocyst

Aldaoud

Joudeh

Al-Momen

et al. 2016

Diagnostic Cytopathology

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Mucinous cystic neoplasms (MCN) of the pancreas can vary from benign to premalignant and malignant. Preoperative diagnosis is essential to offer the patient appropriate treatment. Occasionally these cases may harbor anaplastic carcinoma while clinically masquerade as a pseudocyst. Here in, we report an unusual case of a 37-year old female presented with recurrent abdominal pain that was suspected clinically and by imaging studies to have a pseudocyst. EUS-FNA with internal drainage of the cyst was performed. Cytological evaluation of the cyst fluid showed numerous inflammatory cells composed mainly of many neutrophils admixed with macrophages reminiscent of the usual pseudocyst content but there were scattered rare dyscohesive malignant cells which were highly pleomorphic with multinucleation. Immunostains on the cell block showed immunoreactivity of these cells including the multinucleated cells for Cam 5.2 and AE1/AE3 and focally for Ber-Ep4, Moc -31, and CA19-9. The subsequent resection confirmed the presence of anaplastic (undifferentiated) carcinoma (AC) arising in a MCN of the pancreas. Diagn. Cytopathol. 2016;44:538-542. © 2016 Wiley Periodicals, Inc.

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Cancerous Cyst of the Tail of the Pancreas Simulating Carcinosarcoma

Cited by 8 publications

References 0 publications

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features

Anaplastic Carcinoma Arising in a Mucinous Cystic Neoplasm Masquerading as Pancreatic Pseudocyst

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