Cancer Treatment-Induced Bone Loss: Role of Denosumab in Non-Metastatic Breast Cancer

Dhabhar, Boman

doi:10.2147/bctt.s353332

Cited by 6 publications

(4 citation statements)

References 76 publications

(96 reference statements)

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“…However, it is still controversial whether these genes are associated with BMD. The results of a prospective cohort study showed that VDR CC genotype and COLIA1 TT genotype were associated with increased hip fracture risk in Caucasian women, and this association was independent of BMD and age ( 110 ). ER gene are not associated with osteoporotic fractures, bone mass, or bone turnover ( 111 ).…”

Section: Resultsmentioning

confidence: 99%

Recent advances in the identification of related factors and preventive strategies of hip fracture

Wang

Hou

et al. 2023

Front. Public Health

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Hip fracture is the most devastating type of osteoporosis-related fracture, and is a major worldwide public health problem with a high socioeconomic burden, morbidity rate, and mortality rate. Thus, it is crucial to uncover the risk factors and protective factors to create a hip fracture prevention strategy. In addition to a briefly review of some well accepted risk and protective factors of hip fracture, this review mainly summarized the recent advances in the identification of emerging risk or protective factors for hip fracture, in terms of regional differences in medical services, diseases, drugs, mechanical load, neuromuscular mass, genes, blood types, cultural differences. This review provides a comprehensive review of the associated factors and effective prevention measures for hip fracture, and discusses issues that need further investigation. These issues include the determination of the influencing mechanism of risk factors triggering hip fracture and their interlinked correlation with other factors, as well as the confirmation or correction of emerging factors associated with hip fracture, particularly those that are still controversial. These recent findings will aid in optimizing the strategy for preventing hip fracture.

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Section: Resultsmentioning

confidence: 99%

Recent advances in the identification of related factors and preventive strategies of hip fracture

Wang

Hou

et al. 2023

Front. Public Health

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“…Solo il Dmab 60 mg/ogni 6 mesi ha dati di efficacia sulla riduzione delle fratture nelle donne con CM trattate con inibitori dell'aromatasi e negli uomini con CP in blocco androgenico [45,46] . In una network to mantenuto per i 3 anni di follow-up [40] .…”

Section: Ctibl E Suo Managementunclassified

Joint report SIPMO-SIOMMMS sulla MRONJ in pazienti in cura con antiriassorbitivi per prevenire la CTIBL

Campisi

2024

Dental Cadmos

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OBJECTIVESThis joint report from the Italian Society of Oral Pathology and Medicine (SIPMO) and Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS) aims to define the dental management of breast and prostate cancer patients under low-dose bone modifying agents (LD-BMAs), to reduce their risk to develop Medication-Related Osteonecrosis of the Jaw (MRONJ). The group believes that there is no clarity to date in the prevention/treatment of MRONJ within breast and prostate cancer patient groups, particularly regarding LD-BMA therapy to prevent Cancer Treatment Induced Bone Loss (CTIBL) and the different BMA therapies employed at different stages of the cancer treatment path. To the best of the knowledge of the authors, there are no joint reports, consensus papers or position papers on this specific topic in the literature. MATERIALS AND METHODSAn interdisciplinary expert Italian panel, using the data available of the literature, developed these recommendations for optimal dental management for breast and prostate cancer patients undergoing LD-BMA therapy to prevent CTIBL.

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“…Breast cancer surgery may result in tissue necrosis and scarring at the operated site reducing spine, chest, shoulder girdle, and upper limb mobility, weakening the torso and upper limb muscles, and disturbing biomechanical and postural control [ 7 ]. Radiotherapy and hormonal therapy can precipitate menopause and cause hormonal imbalance contributing to bone mass reduction [ 8 , 9 ]. Immunotherapy is indicated to be associated with the inflammatory diseases of internal organs, chronic fatigue, and sometimes with adverse changes in the central nervous system [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Physical Activity on Static and Dynamic Postural Balance in Women Treated for Breast Cancer: A Systematic Review

Bula

Tatar

Wysocka³

et al. 2023

IJERPH

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Background: Therapies against breast cancer (BC) frequently involve complications that impair patients’ daily function and quality of life, the most common of which are motor coordination and balance disorders, increasing the risk of falls and injuries. In such cases, physical activity is recommended. Designed following the PRISMA guidelines, this study presents a systematic review of randomised and pilot clinical trials investigating the effect of physical exercises on postural balance in women treated for BC. Methods: Scientific databases (PubMed, EBSCO) and the online resources of grey publications were searched for trial reports published between January 2002 and February 2022. The inclusion criteria necessitated full-text, English-language reports from randomised clinical trials (RCTs) or pilot clinical trials (pilot CTs), whose authors used physical exercises to treat women with BC and the experimental and control groups consisted of at least 10 women. The methodological quality of the RCTs and pilot CTs were measured using the Physiotherapy Evidence Database (PEDro) scale and the Methodological Index for Non-Randomized Studies (MINORS), respectively. Data were extracted on the effect of exercise on the women’s static and dynamic balance. Results: Seven reports, five RCTs and two pilot CTs involving a total of 575 women (aged 18–83 years) were included in the systematic review. Their training protocols utilised a variety of aerobic, strength, endurance, sensorimotor, Pilates exercises, and fitness exercises with elements of soccer. The experimental groups usually worked out in fitness or rehabilitation centres under the supervision of physiotherapists or trainers. Training sessions of 30–150 min were held 2 or 3 times a week for 1.5–24 months. Most trials reported that static and dynamic balance in the experimental groups improved significantly more compared with the control groups. Conclusions: Physical exercises are able to improve static and dynamic postural balance in women treated for BC. However, as all evidence in support of this conclusion comes from only two pilot CT and five RCTs whose methodologies varied widely, more high quality research is needed to validate their findings and determine which exercise protocols are the most effective in improving postural control in women with BC.

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Cancer Treatment-Induced Bone Loss: Role of Denosumab in Non-Metastatic Breast Cancer

Cited by 6 publications

References 76 publications

Recent advances in the identification of related factors and preventive strategies of hip fracture

Recent advances in the identification of related factors and preventive strategies of hip fracture

Joint report SIPMO-SIOMMMS sulla MRONJ in pazienti in cura con antiriassorbitivi per prevenire la CTIBL

Effect of Physical Activity on Static and Dynamic Postural Balance in Women Treated for Breast Cancer: A Systematic Review

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