Cancer treatment in the lymphatic system: A prospective targeting employing nanostructured systems

Yukuyama, Megumi Nishitani; Araujo, Gabriel Lima Barros de; Löbenberg, Raimar; Barbosa, Eduardo José; Henostroza, Mirla Anali Bazán; Rocha, Nataly Paredes da; Folchini, Beatriz Rabelo; Peroni, Camilla Midori; Masiero, Jéssica Fagionato; Bou‐Chacra, Nádia Araci

doi:10.1016/j.ijpharm.2020.119697

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…In this case, NPs from 10 to 80 nm, and modified with a neutral charge, improve targeting, and thus, cargo delivery to this system. [ 129 ] In this way, intradermal administration, which favors the diffusion to lymph nodes, and the use of MSR have offered excellent results for developing a cancer vaccine.…”

Section: Discussionmentioning

confidence: 99%

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy

et al. 2022

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Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in clinics, more efforts are required to improve the limitations of current treatments related to lack of effective and targeted cancer antigens delivery to immune cells, dose‐limiting toxicity, and immune‐mediated adverse effects, among others. In recent years, the use of nanomaterials has proven promising to enhance cancer immunotherapy efficacy and reduce side effects. Among nanomaterials, attention has been recently paid to mesoporous silica nanoparticles (MSNs) as a potential multiplatform for enhancing cancer immunotherapy by considering their unique properties, such as high porosity, and good biocompatibility, facile surface modification, and self‐adjuvanticity. This review explores the role of MSN and other nano/micro‐materials as an emerging tool to enhance cancer immunotherapy, and it comprehensively summarizes the different immunotherapeutic strategies addressed to date by using MSN.

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Section: Discussionmentioning

confidence: 99%

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy

et al. 2022

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“…Typical types of integrin were found to be highly expressed in PTC cells and closely related to the recurrence and metastasis of PTC . Therefore, targeted intervention to integrin and related molecules in the pathway can hopefully restrain the poor prognosis. − Integrin-linked kinase (ILK) is a significant downstream kinase protein responding to integrin to modulate cell–matrix interactions under normal conditions. However, emerging pieces of evidences have suggested that the overexpression of ILK in PTC plays a vital role in cell proliferation, lymphangiogenesis, and metastasis during the occurrence and growth of cancer cells, which enables ILK to be a potential target in PTC treatment. − For example, ILK facilitates the formation of epithelial to mesenchymal transition that is crucial in metastasis through downregulating N-cadherin and vimentin and upregulating E-cadherin .…”

Section: Introductionmentioning

confidence: 99%

Charge Reversal Polypyrrole Nanocomplex-Mediated Gene Delivery and Photothermal Therapy for Effectively Treating Papillary Thyroid Cancer and Inhibiting Lymphatic Metastasis

Zhao²,

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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As a traditional treatment for papillary thyroid cancer (PTC), surgical resection of diseased tissues often brings lots of inconveniences to patients, and the tumor recurrence and metastasis are difficult to avoid. Herein, we developed a gene and photothermal combined therapy nanosystem based on a polypyrrole (Ppy)–poly(ethylene imine)–siILK nanocomplex (PPRILK) to achieve minimally invasive ablation and lymphatic metastasis inhibition in PTC simultaneously. In this system, gelatin-stabilized Ppy mainly acted as a photothermal- and photoacoustic (PA)-responsive nanomaterial and contributed to its well-behaved photosensitivity in the near-infrared region. Moreover, gelatin-stabilized Ppy possessed a charge reversal function, facilitating the tight conjunction of siILK gene at physiological pH (7.35–7.45) and its automatic release into acidic lysosomes (pH 4.0–5.5); the proton sponge effect generated during this process further facilitated the escape of siILK from lysosomes to the cytoplasm and played its role in inhibiting PTC proliferation and lymphatic metastasis. With the guidance of fluorescence and PA bimodal imaging, gene delivery and Ppy location in tumor regions could be clearly observed. As a result, tumors were completely eradicated by photothermal therapy, and the recurrences and metastases were obviously restrained by siILK.

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“…Nanocarriers can be used as targeted delivery aids for enhancing lymphatic absorption of small molecule chemotherapeutics based on the unique anatomical character-istics of the LS. 10 A series of parameters, such as size, charge and hydrophobicity, might influence the lymphatic portioning of nanodrugs, in which particle size is a determinant factor. 9 Ideally, the size should range between 10 and 100 nm, larger than the pore size of blood capillaries (9-12 nm) and smaller than that of lymphatic capillaries (100-300 nm), and it is more preferable when the particle size is below 50 nm.…”

Section: Introductionmentioning

confidence: 99%