Cancer treatment by magneto-mechanical effect of particles, a review

Naud, Cécile; Thébault, Caroline; Carrière, Marie; Hou, Yanxia; Morel, R.; Berger, François; Diény, B.; Joisten, Hélène

doi:10.1039/d0na00187b

Cited by 67 publications

(70 citation statements)

References 104 publications

(335 reference statements)

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“…The retention of the IOP within the tumors could be beneficial if numerous AMF applications have to be performed in order to enhance the treatment efficiency 44 . After one MFH application, the ScreenMAG particles were not degraded and no modification of structures or shapes was observed (Supplementary Data S2 D), in accordance with previous reports 1 . The application of this repetitive treatment strategy is also supported by histology that showed that the IOP are within cells 7 days after AMF application.…”

Section: Discussionsupporting

confidence: 91%

“…Their larger surface enables more moieties (like antibodies, aptamers, etc.) to be grafted per particle 1 in order to increase targeting efficiency 2 . Also, due their large size and the high iron content per particle, single particles can be detected by T2*-weighted MRI 3 , which is essential for cell tracking over long periods of time.…”

Section: Introductionmentioning

confidence: 99%

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Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Dallet

Stanicki

Voisin

et al. 2021

Sci Rep

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Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Dallet

Stanicki

Voisin

et al. 2021

Sci Rep

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“…Over the last decade, the concept of glioblastoma treatment was approached based on a mechanical transduction effect rather than a heating radiative effect for tumor cell death, an approach initiated by Kim et al in 2010 [33], and recently reviewed by Naud et al [34] (2020).…”

Section: Introductionmentioning

confidence: 99%

One-Step Soft Chemical Synthesis of Magnetite Nanoparticles under Inert Gas Atmosphere. Magnetic Properties and In Vitro Study

et al. 2020

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Iron oxide nanoparticles have received remarkable attention in different applications. For biomedical applications, they need to possess suitable core size, acceptable hydrodynamic diameter, high saturation magnetization, and reduced toxicity. Our aim is to control the synthesis parameters of nanostructured iron oxides in order to obtain magnetite nanoparticles in a single step, in environmentally friendly conditions, under inert gas atmosphere. The physical–chemical, structural, magnetic, and biocompatible properties of magnetite prepared by hydrothermal method in different temperature and pressure conditions have been explored. Magnetite formation has been proved by Fourier-transform infrared spectroscopy and X-ray diffraction characterization. It has been found that crystallite size increases with pressure and temperature increase, while hydrodynamic diameter is influenced by temperature. Magnetic measurements indicated that the magnetic core of particles synthesized at high temperature is larger, in accordance with the crystallite size analysis. Particles synthesized at 100 °C have nearly identical magnetic moments, at 20 × 103 μB, corresponding to magnetic cores of 10–11 nm, while the particles synthesized at 200 °C show slightly higher magnetic moments (25 × 103 μB) and larger magnetic cores (13 nm). Viability test results revealed that the particles show only minor intrinsic toxicity, meaning that these particles could be suited for biomedical applications.

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“…Thus, there are several approaches to tune relaxation times and, therefore, the nanoparticle relaxation behavior. 32 Some comprehensive reviews and elegant studies 33,34 have reported that the Brownian rotation can be the most important mechanism for magnetic relaxation of nanoparticles with large magnetic anisotropy, such as Co-ferrite nanoparticles. In this case, the hydrodynamic diameter is a critical parameter to determine the power absorption in magnetic hyperthermia.…”

Section: Nanoscale Advances Accepted Manuscriptmentioning

confidence: 99%

Tunable magnetothermal properties of cobalt-doped magnetite–carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy

et al. 2021

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Cancer treatment by magneto-mechanical effect of particles, a review

Abstract: Cancer treatment by magneto-mechanical effect of particles (TMMEP), using low frequency magnetic stimulation, is a growing research field. This review reports the main in vitro and in vivo results, summarizing the various approaches and perspectives.

Cited by 67 publications

References 104 publications

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

One-Step Soft Chemical Synthesis of Magnetite Nanoparticles under Inert Gas Atmosphere. Magnetic Properties and In Vitro Study

Tunable magnetothermal properties of cobalt-doped magnetite–carboxymethylcellulose ferrofluids: smart nanoplatforms for potential magnetic hyperthermia applications in cancer therapy

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