Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Mahmoud, Yasmina K; Abdelrazek, Heba M. A.

doi:10.1016/j.biopha.2019.108783

Cited by 126 publications

(115 citation statements)

References 154 publications

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“…TQ can also undergo a non-enzymatic reduction through its interaction with glutathione (GSH) forming glutathionyl-dihydrothymoquinone with antoxidant activity. oxidoreductase can generate thymohydroquinone with potent anti-oxidant activity [25][26][27][28]. TQ can also undergo a non-enzymatic reduction through its interactions with glutathione forming glutathionyl-dihydrothymoquinone in physiological conditions [29].…”

Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

“…A number of studies have documented the role of the pro-oxidant activity of TQ in its chemopreventive and anticancer activities [26,32]. Conversion of TQ into semiquinone is accompanied by the release of reactive oxygen species (ROS) that include superoxide, peroxide, and hydroxyl radicals.…”

Section: Pro-oxidant Role Of Tq In Chemopreventionmentioning

confidence: 99%

“…Anti-oxidant activity of TQ has also been attributed to its inhibitory effect on diethylnitrosamine-induced hepatic carcinogenesis through a similar upregulation of anti-oxidant enzyme levels [49]. In addition, the anti-oxidant effect of TQ is also associated with the ability of TQ to suppress the adverse effects of chemotherapeutic agents such as cyclophosphamide [52], cisplatin [53,54], and doxorubicin [55] in non-cancerous cells and tissues [26]. Thus, TQ-mediated increase in the levels of anti-oxidant enzyme plays a significant role in the oxidative stress-induced tumorigenesis and chemically induced carcinogenesis as well as the cytoprotection against chemotherapeutic toxicity [56].…”

Section: Anti-oxidant Role Of Tq In Chemopreventionmentioning

confidence: 99%

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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

Section: Pro-oxidant Role Of Tq In Chemopreventionmentioning

confidence: 99%

Section: Anti-oxidant Role Of Tq In Chemopreventionmentioning

confidence: 99%

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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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“…2-isopropyl-5-methyl-1,4-benzoquinone). Thymoquinone is acquired from the seeds of Nigella sativa that is bound up Ranunculaceae family [11,12]. Thymoquinone has been used for various purposes such as antioxidant, anti-inflammatory, immunomodulator, anticancer, antimicrobial, antihistaminic, and antineoplastic [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

Turkoz¹,

Türköz²,

Önger³

et al. 2021

Turk J Med Sci

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The stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats Abstract Background/aim: This study was aimed to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy. Materials and methods: Twenty female Wistar Albino rats were used in our study. The rats were randomly divided into two groups as Sham and Surgery+Thymoquinone. Both groups underwent laminectomy at L1, under general anesthesia. The sham group was not subjected to any drug application. The second group was treated with intraperitoneal 10 mg/kg thymoquinone per day for a period of 28 days, following the same surgical procedure. All the groups were sacrificed after four weeks and the laminectomy area was examined in terms of new bone volume, capillary volume and fibrosis volume using stereological approaches. Results: Statistically significant differences were found between the Sham and Surgery+Thymoquinone groups, in terms of the new bone volume (p=0.01), capillary volume (p=0.01) and fibrosis volume (p<0.001). It was noted that thymoquinone caused significant increase in the new bone volume and vascular volume and a significant decrease in the fibrosis volume. Conclusion: The results of our study indicate that thymoquinone is effective in decreasing the peridural fibrosis when applied on laminectomy model.

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“…Thymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ), the richest essential of the volatile oil also existing in the fixed oil, is the organically active composite of Black Cumin seeds [13].…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone-loaded ethosome with breast cancer potential: optimization, in vitro and biological assessment

Nasri

Ebrahimi-Hosseinzadeh

Rahaie

et al. 2020

J Nanostruct Chem

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Ethosomes are most commonly used vesicular delivery system compared to other lipidic vesicles due to its ethanolic content. Thymoquinone (TQ), the main biologically active complex of Black Cumin seed, has established anticancer activities in several tumors. In this work, the preparation of ethosome for TQ encapsulation by response surface method (RSM) was developed. Central composite design (CCD) was used to optimize three effective parameters involved in ethosome structure including phospholipid, cholesterol and ethanol concentration and the combined effects of them, as well. The obtained optimum values for the variables were phospholipid 5% (W/W), ethanol 45% (V/V) and cholesterol 1.5% (W/W) which were validated by experimental assay. The ethosomal formulation was more characterized for vesicle shape, size, zeta potential and entrapment efficiency percentage. The result showed an efficiency of 99% for drug entrapment with average vesicle size and zeta potential of 20 ± 1 nm and − 63 ± 2 mv, respectively. A quadratic model with a high adequacy (R 2) for size and zeta potential of 0.9319 and 0.9338, respectively, was resulted from RSM and experimental assay. Thymoquinone (TQ) encapsulated in optimized ethosome. Also, cellular toxicity and release test was done. The toxicity and release curves were obtained and the cytotoxic activity of the ethosomic TQ against MCF-7 cell lines was greater than free TQ. IC50 values of free TQ, ethosomic TQ, were found to be 1.10 µg/ml, 0.95 µg/ml, respectively. The generated model suggests a new approach to prediction and experimental lipidic carriers.

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Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Cited by 126 publications

References 154 publications

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

Thymoquinone-loaded ethosome with breast cancer potential: optimization, in vitro and biological assessment

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