Cancer therapy's impact on lipid metabolism: Mechanisms and future avenues

Bhatnagar, Roshni; Dixit, Neal M.; Yang, Eric H.; Sallam, Tamer

doi:10.3389/fcvm.2022.925816

Cited by 13 publications

(8 citation statements)

References 188 publications

(199 reference statements)

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“…Hypogonadism predisposes patients to osteoporosis and metabolic complications, including dyslipidemia [ 26 , 27 ]. Dyslipidemia after HSCT causes injury to endothelial cells, leading to cardiovascular diseases such as hypertension and coronary artery diseases [ 28 , 29 ]. The prevalence of metabolic syndrome, characterized by obesity, insulin resistance, dyslipidemia, and hypertension, increased in patients who underwent HSCT [ 3 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…26,27) Dyslipidemia after HSCT causes injury to endothelial cells, leading to cardiovascular diseases such as hypertension and coronary artery diseases. 28,29) The prevalence of metabolic syndrome, characterized by obesity, insulin resistance, dyslipidemia, and hypertension, increased in patients who underwent HSCT. 3,24) Potential risk factors for posttransplant DM include age, hypothalamic and pituitary functions, GVHD, and immunosuppressive therapy.…”

Section: Discussionmentioning

confidence: 99%

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Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents

Hwang,

Lee,

Yoon

et al. 2024

Ann Pediatr Endocrinol Metab

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Purpose: As the survival rate from pediatric cancers has increased significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae in childhood cancer survivors who received hematopoietic stem cell transplantation (HSCT).Methods: This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. The median follow-up duration after HSCT was 14 years.Results: Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n=100) were at higher risk of endocrine complications than those who received it at prepubertal age (79% vs. 56%, <i>P</i>=0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Being female, pubertal age at HSCT, and glucocorticoid use were predictors of an increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with being female, pubertal age at HSCT, and high-dose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia.Conclusion: This study demonstrates that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents

Hwang,

Lee,

Yoon

et al. 2024

Ann Pediatr Endocrinol Metab

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“…When cancer survivors have longer life expectancy and are treated more cumulatively with cytotoxic treatments, they are more in danger of dying from CVD [39]. Jennifer L Patnaik's work counted the percentage distribution of the main reasons for death among patients with breast cancer aged 66 and above.…”

Section: Cardiovascular Risk Among Breast Cancer Survivorsmentioning

confidence: 99%

Lipoprotein(a) in patients with breast cancer after chemotherapy: exploring potential strategies for cardioprotection

Wang,

2023

Lipids Health Dis

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Developments in neoadjuvant and adjuvant chemotherapy (CHT) have led to an increase in the number of breast cancer survivors. The determination of an appropriate follow-up for these patients is of increasing importance. Deaths due to cardiovascular disease (CVD) are an important part of mortality in patients with breast cancer.This review suggests that chemotherapeutic agents may influence lipoprotein(a) (Lp(a)) concentrations in breast cancer survivors after CHT based on many convincing evidence from epidemiologic and observational researches. Usually, the higher the Lp(a) concentration, the higher the median risk of developing CVD. However, more clinical trial results are needed in the future to provide clear evidence of a possible causal relationship. This review also discuss the existing and emerging therapies for lowering Lp(a) concentrations in the clinical setting. Hormone replacement therapy, statins, proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors, Antisense oligonucleotides, small interfering RNA, etc. may reduce circulating Lp(a) or decrease the incidence of CVD.

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“…40,41 Therapeutics are often employed for prevention and treatment of diseases, in hopes of altering the expression of biomolecules back to a normal healthy state. 42 In short, endogenous species can be altered in response to an exogenous drug treatment. 42,43 This property has made MSI of exogenous therapeutics increasingly popular to study, as investigators can map therapeutics spatially and monitor how endogenous species are altered.…”

Section: Introductionmentioning

confidence: 99%

“…42 In short, endogenous species can be altered in response to an exogenous drug treatment. 42,43 This property has made MSI of exogenous therapeutics increasingly popular to study, as investigators can map therapeutics spatially and monitor how endogenous species are altered. 27,44 Since biomolecules are involved in many key biological processes and therapeutic intervention can influence their expression, they have become popular targets for biomarker discovery.…”

Section: Introductionmentioning

confidence: 99%