Cancer Therapy; Prospects for Application of Nanoparticles for Magnetic-Based Hyperthermia

Rahban, Dariuosh; Doostan, Mahtab; Salimi, Ali

doi:10.1080/07357907.2020.1817482

Cited by 16 publications

(11 citation statements)

References 141 publications

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“…Owing to their super magnetic capabilities, biocompatibility, high specialized region, appropriate nano-sized particulates, and lower toxic effects, Fe 2 O 3 nanomaterials are one of the most promising alternatives for magnetic-responsive devices according to the researchers [ 31 , 103 , 104 ] ( Figure 3 ). Improved drug loading potential, increased carrier durability, and opportunity for future functionalization might be achieved by coating iron oxide NPs using appropriate polymers [ 67 , 105 , 106 , 107 , 108 ]. In vitro experiments using human hepatocarcinoma SMMC-7721 cells, Yan et al [ 109 ] employed a combination of Fe 2 O 3 nanomaterials and magnetic fluid hyperthermia (MFH) and found that apoptosis was dose-dependent, and proliferation was inhibited.…”

Section: Fe 2 O 3 In Magnetic-r...mentioning

confidence: 99%

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

et al. 2022

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Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. In this regard, metal oxide nanoparticles show great potential as versatile tools in biomedical science. In particular, iron oxide nanoparticles with different shape and sizes hold outstanding physiochemical characteristics, such as high specific area and porous structure that make them idoneous nanomaterials to be used in diverse aspects of medicine and biological systems. Moreover, due to the high thermal stability and mechanical strength of Fe2O3, they have been combined with several polymers and employed for various nano-treatments for specific human diseases. This review is focused on summarizing the applications of Fe2O3-based nanocomposites in the biomedical field, including nanocarriers for drug delivery, tissue engineering, and wound healing. Additionally, their structure, magnetic properties, biocompatibility, and toxicity will be discussed.

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Section: Fe 2 O 3 In Magnetic-r...mentioning

confidence: 99%

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

et al. 2022

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“…Magnetic hyperthermia treatment (MHT) utilizes heat that is generated by MNPs under an alternating MF to selectively kill tumor cells [584][585][586]. When exposed to an alternating magnetic field (AMF), MNPs can generate heat via hysteresis loss (large multidomain MNPs) or through Neel-and Brownian relaxation losses (typically small, singlecore MNPs) [587].…”

Section: Magnetic Hyperthermia Ad Cancer Treatmentmentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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“…The heat produced can be utilized for cancer cell destruction, drug release from heat‐sensitive vesicles, and heat‐sensitive receptor activation. [ 87 ] Heat‐induced cellular effects have been already extensively reviewed. [ 88 ] Finally, the third mechanism occurs when the acquired energy exerts magnetomechanical effects on cells when MNPs are subjected to gradient or homogeneous SMFs.…”

Section: Interacting With Cells Through Magnetismmentioning

confidence: 99%

“…Another route is the magnetic delivery of heat for hyperthermia, which can effectively raise the local tissue temperature, resulting in the eradication of target cancer cells, a decrease in tumor size and progression in vivo, and an enhancement of anti‐tumor drug efficacy. [ 87,88 ] Finally, cell death can also occur as a consequence of the mechanical ablation of cellular structures via force or torque application. [ 185 ] For instance, rotating MFs can actuate the rotation of magnetic carbon nanotubes, rods, or particles in the cell, causing a mechanical disruption of its intracellular components.…”

Section: Cell Processes Affected By Magnetismmentioning

confidence: 99%

Engineered Magnetic Nanocomposites to Modulate Cellular Function

Filippi

Garello

Yaşa

et al. 2021

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Magnetic nanoparticles (MNPs) have various applications in biomedicine, including imaging, drug delivery and release, genetic modification, cell guidance, and patterning. By combining MNPs with polymers, magnetic nanocomposites (MNCs) with diverse morphologies (core–shell particles, matrix‐dispersed particles, microspheres, etc.) can be generated. These MNCs retain the ability of MNPs to be controlled remotely using external magnetic fields. While the effects of these biomaterials on the cell biology are still poorly understood, such information can help the biophysical modulation of various cellular functions, including proliferation, adhesion, and differentiation. After recalling the basic properties of MNPs and polymers, and describing their coassembly into nanocomposites, this review focuses on how polymeric MNCs can be used in several ways to affect cell behavior. A special emphasis is given to 3D cell culture models and transplantable grafts, which are used for regenerative medicine, underlining the impact of MNCs in regulating stem cell differentiation and engineering living tissues. Recent advances in the use of MNCs for tissue regeneration are critically discussed, particularly with regard to their prospective involvement in human therapy and in the construction of advanced functional materials such as magnetically operated biomedical robots.

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Cancer Therapy; Prospects for Application of Nanoparticles for Magnetic-Based Hyperthermia

Cited by 16 publications

References 141 publications

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Engineered Magnetic Nanocomposites to Modulate Cellular Function

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