Cancer Therapy and Imaging Through Functionalized Carbon Nanotubes Decorated with Magnetite and Gold Nanoparticles as a Multimodal Tool

Saghatchi, Fatemeh; Mohseni-Dargah, Masoud; Akbari‐Birgani, Shiva; Saghatchi, Samaneh; Kaboudin, Babak

doi:10.1007/s12010-020-03280-3

Cited by 27 publications

(12 citation statements)

References 22 publications

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“…Furthermore, there are several examples of hybrid carbon structures [ 80 , 81 ]. These nanohybrids are mainly involved in investigations where two or more physical stimulations are combined to achieve tumor ablation [ 82 , 83 ].…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

“…There are nanomaterials responsive to more stimulations, as gold [ 173 ]. Otherwise, hybrid NPs comprising materials with different properties could be employed, and each component could interact with a single input [ 83 ]. This has indeed the remarkable advantage to increase the therapeutic outcomes further reducing side effects [ 174 ], and several possible strategies are reported in the literature.…”

Section: Combined Stimuli For Enhanced Therapymentioning

confidence: 99%

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Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Section: Combined Stimuli For Enhanced Therapymentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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“…Figure S9 then shows TEM images of commercially produced nanotubes. MWCNTs have been used in applications such as catalyst supports, sensors, conductive yarns, CT, and MRI imaging. , Commonly, MWCNTs are synthesized using heavy metal catalysts, which are known to be cytotoxic . Alternatively, this method uses only calcium-based material, which is one of the most abundant elements in biological systems.…”

Section: Results and Discussionmentioning

confidence: 99%

Graphene-like Carbon from Calcium Hydroxide

et al. 2021

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The development of inexpensive and environmentally friendly graphene-like carbon is critical for its integration into industrial products. This work highlights the production of graphene-like carbon structures from calcium hydroxide. The chemical vapor deposition conditions to grow graphitic carbon on a calcium hydroxide catalyst are reported. Acetylene, steam, and calcium hydroxide are used to grow a crumpled carbon morphology. The crumpled carbon resulted in a high surface area of 1276 m 2 /g and high electrical conductivity (>10 5 S/m). Additionally, the significance and origin of the C 1s X-ray photoelectron spectroscopy (XPS) π−π* plasmon loss peak as it is related to high electrical conductivity is reported. A unique mechanism for the catalytic process involving calcium acetylide is proposed. Several deposition times, steam concentration, and catalyst morphology were tested to synthesize a variety of carbon morphologies from calcium-based materials. Crumpled carbon, hollow nanospheres, bamboo-like carbon nanotubes, multi-walled carbon nanotubes, and graphene fiber morphologies were all formed using calcium-based catalysts. Multiple reaction conditions, a scaled reaction (300 g), and catalyst recyclability were investigated. Calcium-based materials were then used as catalysts for the growth of other graphene-like carbons.

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“…Besides, the small size of CNTs enables them to cross the endothelial barriers, and subsequently to become a targetable material to reach tumor regions. Saghatchi et al designed a kind of functionalized MWNTs that was modified with both magnetic Fe 3 O 4 and gold NPs, obtaining mf -MWNT/AuNPs for cancer imaging and therapy [ 145 ]. According to the ultrasonic imaging effects, these NPs showed high contrast under all of the employed concentrations, exhibiting the possibility to become a type of contrast agent in ultrasonography.…”

Section: Carbon Nanotubes In Cancer Diagnosismentioning

confidence: 99%

Insights on functionalized carbon nanotubes for cancer theranostics

et al. 2021

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Despite the exciting breakthroughs in medical technology, cancer still accounts for one of the principle triggers of death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement in cancer therapy with gigantic application potential because of their ability in achieving precise and controlled drug release, elevating drug solubility and reducing adverse effects. Carbon nanotubes (CNTs), one of the most promising carbon-related nanomaterials, have already achieved much success in biomedical field. Due to their excellent optical property, thermal and electronic conductivity, easy functionalization ability and high drug loading capacity, CNTs can be applied in a multifunctional way for cancer treatment and diagnosis. In this review, we will give an overview of the recent progress of CNT-based drug delivery systems in cancer theranostics, which emphasizes their targetability to intracellular components of tumor cells and extracellular elements in tumor microenvironment. Moreover, a detailed introduction on how CNTs penetrate inside the tumor cells to reach their sites of action and achieve the therapeutic effects, as well as their diagnostic applications will be highlighted. Graphic Abstract

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Cancer Therapy and Imaging Through Functionalized Carbon Nanotubes Decorated with Magnetite and Gold Nanoparticles as a Multimodal Tool

Cited by 27 publications

References 22 publications

Remotely Activated Nanoparticles for Anticancer Therapy

Remotely Activated Nanoparticles for Anticancer Therapy

Graphene-like Carbon from Calcium Hydroxide

Insights on functionalized carbon nanotubes for cancer theranostics

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