Cancer theranostic platforms based on injectable polymer hydrogels

Abstract

Theranostic platforms combining therapy with diagnosis not only prevent the undesirable biological responses that may occur when these processes are conducted separately, but also supply individualized therapies for patients. Polymer...

Recent strategies to develop pH-sensitive injectable hydrogels

“…[33][34][35] This gives excellent biocompatibility to the hydrogels and allows the imbibing of hydrophilic therapeutic agents. 36,37 In this review, we describe general strategies used to develop injectable pH-responsive biomaterials for controlled delivery applications. We focus on the fabrication of different pH-responsive biomaterials prepared using either cationic copolymers or anionic polymers.…”

Advanced injectable hydrogels for cartilage tissue engineering

“…Pre-gelated hydrogels are injectable due to their self-healing and shear thinning ( Riley et al, 2019 ). As the shear rate increased (during injection), the stickiness of the hydrogel decreased dramatically, reflecting the shear-thinning behavior ( Thambi et al, 2017 ; Wang et al, 2021d ). Although the injection forces may interfere with the cross-linking structure and trigger the gel-sol transition, the following self-healing process can rebuild the gel after removing the strain ( Liu and Hsu, 2018 ).…”

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

“…19 There are various strategies to develop hydrogels, but generally, they have a three-dimensional (3D) polymer mesh structure or network that absorbs considerable amounts of water and retains their swollen state by stabilisation via non-covalent bonding of water within their interstices. 20,21 Hydrogels can be made with natural and synthetic polymers and used for different biomedical applications such as 3D cell culture, tissue engineering, and drug delivery. 22 Usually, synthetic polymers provide better reproducibility and higher mechanical strength but lower biocompatibility than natural polymers.…”