Cancer-targeted reactive oxygen species-degradable polymer nanoparticles for near infrared light-induced drug release

Seah, Geok Leng; Yu, Jeong Heon; Koo, Bon Il; Lee, Dong Jae; Nam, Yoon Sung

doi:10.1039/c8tb02323a

Cited by 22 publications

(13 citation statements)

References 58 publications

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“…Meanwhile, inflammatory cells frequently infiltrate the tumor microenvironment and produce large amounts of ROS in the extracellular matrix (ECM) of tumors . Therefore, various ROS‐responsive species have been employed to build smart materials, including phenylboronic esters/acids, sulfides, thioketals, and selenium . The most attractive moiety is phenylboronic esters/acids as its prompt response toward H 2 O 2 (the most abundant ROS in organism) .…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release

Chen

Xiang

et al. 2019

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mabi.201900331.Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a novel redox dual-responsive amphiphilic block copolymer (ABP) that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized, and the DOX loaded nanoparticles (BSN-DOX) based on ABPs with varied hydrophobic block length are fabricated for DOX delivery. The self-immolative leaving reaction of phenylboronic ester triggered by extracellular ROS and the cleavage of disulfide linkages induced by intracellular GSH both lead to rapid DOX release from BSN-DOX, resulting in an on-demand DOX release. Moreover, BSN-DOX show better tumor inhibition and lower side effects in vivo compared with free drug.The authors declare no conflict of interest.

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Section: Introductionmentioning

confidence: 99%

Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release

Chen

Xiang

et al. 2019

Macromolecular Bioscience

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“…Moreover, a decrease in the loading yield of meso-tetraphenylporphyrin in NPs accelerated the release of PTX, thus suggesting the possibility a way to modulate the release rate of encapsulated drugs. Loaded micelles showed a high efficiency in tumor growth suppression without any significant premature drug leakage [76,77]. In another study, Sun et al explored a PEGylated polyphosphate polymer containing thioketal groups to form self-assembled NPs.…”

Section: Tk Incorporated Into Polymers and Pdtmentioning

confidence: 99%

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

et al. 2022

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Reactive oxygen species (ROS)-sensitive drug delivery systems (DDS) specifically responding to altered levels of ROS in the pathological microenvironment have emerged as an effective means to enhance the pharmaceutical efficacy of conventional nanomedicines, while simultaneously reducing side effects. In particular, the use of the biocompatible, biodegradable, and non-toxic ROS-responsive thioketal (TK) functional group in the design of smart DDS has grown exponentially in recent years. In the design of TK-based DDS, different technological uses of TK have been proposed to overcome the major limitations of conventional DDS counterparts including uncontrolled drug release and off-target effects. This review will focus on the different technological uses of TK-based biomaterials in smart nanomedicines by using it as a linker to connect a drug on the surface of nanoparticles, form prodrugs, as a core component of the DDS to directly control its structure, to control the opening of drug-releasing gates or to change the conformation of the nano-systems. A comprehensive view of the various uses of TK may allow researchers to exploit this reactive linker more consciously while designing nanomedicines to be more effective with improved disease-targeting ability, providing novel therapeutic opportunities in the treatment of many diseases.

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“…Hence, combining chemotherapy with photothermia will help to reduce the side effects and drug resistance of single chemotherapy, leading to better therapeutic outcomes 12 . Researchers can regulate the release behavior of chemotherapy drugs via heat generated by the tuned light to achieve better curative effect 13,14 . Although multifunctional nanoparticles show great advantage in synergistic therapeutic for antitumor, it is difficult to enrich and track the nanovehicle in target sites just rely on the weak enhanced permeation and retention (EPR) effect, which limited further clinic application 15 .…”

Section: Introductionmentioning

confidence: 99%

A multifunctional dual‐shell magnetic nanocomposite with near‐infrared light response for synergistic chemo‐thermal tumor therapy

Shi

Wang

et al. 2020

J Biomed Mater Res

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The synergistic tumor therapy in single nanoplatform has always been the goal for high efficacy tumor treatment while still remains great challenge. This paper reports a versatile nanotheranostic platform enlisting magnetic iron oxide nanoparticles, polydopamine (PDA), gold nanocages (Au nanocage) and metal organic framework (MOF, MIL101‐NH2) in order to achieve synergistic chemothermal tumor therapy both in vitro and in vivo. The prepared magnetic photothermal nanoparticles (MPNPs) exhibit high drug loading capacity (31.34 mg/g), superior photo‐thermal capacity (11.5°C enhancement in 180 s), low bio‐toxicity, good magnetic resonance with a low dosage of 22 μg/g, as well as high antitumor efficacy in vivo. Such a novel and multifunctional nanoplatform is expected to find promising applications in target tumor synergistic therapy.

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Cancer-targeted reactive oxygen species-degradable polymer nanoparticles for near infrared light-induced drug release

Abstract: Nanocarriers can be translocated to the peripheral region of tumor tissues through the well-known enhanced permeability and retention effects.

Cited by 22 publications

References 58 publications

Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release

Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

A multifunctional dual‐shell magnetic nanocomposite with near‐infrared light response for synergistic chemo‐thermal tumor therapy

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