Cancer-targeted chemotherapy: Emerging role of the folate anchored dendrimer as drug delivery nanocarrier

Rajani, Chitra; Borisa, Pooja; Karanwad, Tukaram; Borade, Yogeshwari; Patel, Vruti; Rajpoot, Kuldeep; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814527-2.00007-x

Cited by 30 publications

(25 citation statements)

References 102 publications

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“…Selected nanoparticles (NPs) have some essential characteristics that suggest their potential application to attain efficient targeting of the colon for the optimal effect of Met. These characteristics include: slight burst release of drug in the early phase; easy permeability; resistance to degradation; hydrophobicity; high surface charge; high drug loading; nontoxic nature; high binding as well as deep permeating ability through mucous membrane owing to their nanosize [ 10 , 11 , 12 , 13 ]. Several polymers such as alginate and chitosan (CH) [ 14 ] have been exploited not only for their mucoadhesive effect in GI but also for discovering their probable effectiveness in the colon milieu.…”

Section: Introductionmentioning

confidence: 99%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, tripolyphosphate concentration, and acetic acid concentration as material attributes, stirring speed, and stirring time as process parameters, whereby their influence on two dependent variables such as particle size (PS) and %entrapment efficiency (%EE) was studied. MetNp were synthesized by employing an ionic-gelation technique and optimized formula obtained from the QbD design study. PS and %EE studies revealed the formation of MetNp with 558.06 ± 2.52 nm and 59.07 ± 2.15%, respectively. Furthermore, a Met release study in various simulated gastro-intestinal media suggested pH-triggered (pH > 7.0) and sustained release profile of Met from Eudragit S100 enteric-coated MetNp capsule (MetNp cap). Moreover, the stability investigation of formulations confirmed good stability with respect to their PS and residual drug content (RDC) at different temperature conditions. In conclusion, the QbD method was effectively utilized in the development of MetNp and enteric-coated MetNp cap depicting their potential to release Met through MetNp cap only in the colon region and can be utilized for the treatment of amoebiasis in the colon.

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Section: Introductionmentioning

confidence: 99%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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“…Finally, it is crucial to develop ligand-conjugated nanosized delivery systems that actively target receptors specifically expressed in cancer cells; in response, due to the overwhelming accumulation in tumor sites, this strategy is speculated to outperform the passive targeting strategy. 21 , 123 , 124 …”

Section: Discussionmentioning

confidence: 99%

Nanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer

Wu¹,

Ou²,

Shang³

et al. 2021

DDDT

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Lung cancer remains the most common cancer worldwide. Although significant advances in screening have been made and early diagnosis strategies and therapeutic regimens have been developed, the overall survival rate remains bleak. Curcumin is extracted from the rhizomes of turmeric and exhibits a wide range of biological activities. In lung cancer, evidence has shown that curcumin can markedly inhibit tumor growth, invasion and metastasis, overcome resistance to therapy, and even eliminate cancer stem cells (CSCs). Herein, the underlying molecular mechanisms of curcumin were summarized by distinct biological processes. To solve the limiting factors that curtail the clinical applications of curcumin, nanoformulations encapsulating curcumin were surveyed in detail. Nanoparticles, including liposomes, micelles, carbon nanotubes (CNTs), solid lipid nanoparticles (SLNs), nanosuspensions, and nanoemulsions, were explored as proper carriers of curcumin. Moreover, it was firmly verified that curcumin has the ability to sensitize lung cancer cells to chemotherapeutic drugs, such as cisplatin and docetaxel, and to various targeted therapies. Regarding the advantages and drawbacks of curcumin, we concluded that combination therapy based on nanoparticles would be the optimal approach to broaden the application of curcumin in the clinic in the near future.

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“…Cancer is a group of disease in which abnormal cells grow and divide in a rapid way without any control. In addition, these abnormal cells are also responsible for destruction of normal body tissues [1] . According to the prevailing theory of cancer, the normal cells convert into the cancerous cells, which eventually lead to abnormal cellular, molecular and biochemical networking of normal cells.…”

Section: Introductionmentioning

confidence: 99%

“…But these treatment strategies possess potential drawback due to their non-selectivity, which produces harmful effects on normal tissues too. Hence, to overcome these serious drawbacks there is need of novel targeting treatment approaches [1] .…”

Section: Introductionmentioning

confidence: 99%

An understanding of mitochondria and its role in targeting nanocarriers for diagnosis and treatment of cancer

Choudhary

Goykar

Karanwad

et al. 2021

Asian Journal of Pharmaceutical Sciences

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Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cancer therapy due to its specificity. In cancer, several targets have been explored which could be utilized for the better treatment of disease. Mitochondria, the so-called powerhouse of cell, portrays significant role in the survival and death of cells, and has emerged as potential target for cancer therapy. Direct targeting and nanotechnology based approaches can be tailor-made to target mitochondria and thus improve the survival rate of patients suffering from cancer. With this backdrop, in present review, we have reemphasized the role of mitochondria in cancer progression and inhibition, highlighting the different targets that can be explored for targeting of disease. Moreover, we have also summarized different nanoparticulate systems that have been used for treatment of cancer via mitochondrial targeting.

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Cancer-targeted chemotherapy: Emerging role of the folate anchored dendrimer as drug delivery nanocarrier

Cited by 30 publications

References 102 publications

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Nanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer

An understanding of mitochondria and its role in targeting nanocarriers for diagnosis and treatment of cancer

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