Cancer Survivorship—Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations

Travis, Lois B.; Rabkin, Charles S.; Brown, Linda Morris; Allan, James M.; Alter, Blanche P.; Ambrosone, Christine B.; Begg, Colin B.; Caporaso, Neil E.; Chanock, Stephen J.; DeMichele, Angela; Figg, William D.; Gospodarowicz, Mary K.; Hall, Eric J.; Hisada, Michie; Inskip, Peter D.; Kleinerman, Ruth A.; Little, John B.; Malkin, David; Ng, Andrea K.; Offit, Kenneth; Pui, Ching Hon; Robison, Leslie L.; Rothman, Nathaniel; Shields, Peter G.; Strong, Louise C.; Taniguchi, Toshiyasu; Tucker, Margaret A.; Greene, Mark H.

doi:10.1093/jnci/djj001

Cited by 300 publications

(222 citation statements)

References 116 publications

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“…In 1889, Billroth documented several such cases as rare events. However, in recent years, several studies have noted multiple primary cancers frequently due to the prolonged survival of patients who have previously been cured of a primary cancer [1] . Multiple primary cancers are defined as either synchronous tumors or metachronous tumors, according to whether the diagnostic intervals of the lesions are shorter or longer than six months, respectively [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Metachronous bile duct cancer nine years after resection of gallbladder cancer

Joo

Kim²,

Jeon³

et al. 2009

WJG

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We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a welldifferentiated adenocarcinoma, with negative resection margins ( T2N0M0, stage ⅠB). Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type Ⅲ a, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy. The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis (T1N1M0, stage ⅡB). Twelve months after the second operation, the patient is well, with no signs of recurrence. This case is compared with 11 other cases of metachronous biliary tract cancer published in the world medical literature.

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Section: Introductionmentioning

confidence: 99%

Metachronous bile duct cancer nine years after resection of gallbladder cancer

Joo

Kim²,

Jeon³

et al. 2009

WJG

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“…in organs adjacent to the tumor [reviewed in (Curtis et al, 2006;Hall, 2006;Little, 2001;Ron, 2003)]. With screening resulting in patients being treated at younger ages, and withincreasing patient survival times, second cancers are becoming of increasing concern (Travis et al, 2006). The long time lag between radiotherapy and second cancer incidence means that few direct data, or none, are available on second cancers induced by recently introduced treatment modalities, so that model-based predictions are important.…”

Section: Introductionmentioning

confidence: 99%

Second cancers after fractionated radiotherapy: Stochastic population dynamics effects

Sachs

Shuryak

Brenner

et al. 2007

Journal of Theoretical Biology

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When ionizing radiation is used in cancer therapy it can induce second cancers in nearby organs. Mainly due to longer patient survival times, these second cancers have become of increasing concern. Estimating the risk of solid second cancers involves modeling: because of long latency times, available data is usually for older, obsolescent treatment regimens. Moreover, modeling second cancers gives unique insights into human carcinogenesis, since the therapy involves administering well characterized doses of a well studied carcinogen, followed by long-term monitoring.In addition to putative radiation initiation that produces pre-malignant cells, inactivation (i.e. cell killing), and subsequent cell repopulation by proliferation can be important at the doses relevant to second cancer situations. A recent initiation/inactivation/proliferation (IIP) model characterized quantitatively the observed occurrence of second breast and lung cancers, using a deterministic cell population dynamics approach. To analyze if radiation-initiated pre-malignant clones become extinct before full repopulation can occur, we here give a stochastic version of this IIP model. Combining Monte Carlo simulations with standard solutions for time-inhomogeneous birth-death equations, we show that repeated cycles of inactivation and repopulation, as occur during fractionated radiation therapy, can lead to distributions of pre-malignant cells per patient with variance ≫ mean, even when pre-malignant clones are Poisson-distributed. Thus fewer patients would be affected, but with a higher probability, than a deterministic model, tracking average pre-malignant cell numbers, would predict. Our results are applied to data on breast cancers after radiotherapy for Hodgkin disease. The stochastic IIP analysis, unlike the deterministic one, indicates: a) initiated, pre-malignant cells can have a growth advantage during repopulation, not just during the longer tumor latency period that follows; b) weekend treatment gaps during radiotherapy, apart from decreasing the probability of eradicating the primary cancer, substantially increase the risk of later second cancers.

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“…The predisposing risk factors for dual malignancy include field cancerization, tobacco and alcohol, genetic predisposition (Li-Fraumeni syndrome and Beckwith-Weidemann syndrome, Cowden syndrome), history of prior external radiation, radioiodine ablation or chemotherapy, environmental risk factors and improved survival [8].…”

Section: Discussionmentioning

confidence: 99%

Hypoxemia in minimally invasive esophagectomy for squamous cell carcinoma of lower esophagus

Lam¹,

Trung²

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.comSynchronous dual malignancy of papillary carcinoma thyroid and squamous cell carcinoma tongue: A case report Tej Prakash Soni, Sajal Goel, Lalit Mohan Sharma, Anil Kumar Gupta, Shantanu Sharma, Ravindra Gothwal ABSTRACT Introduction: Patients with thyroid carcinoma have increased risk for development of second malignancy either synchronous or metachronous. We are reporting a rare case of synchronous squamous cell carcinoma oral tongue and papillary thyroid carcinoma. Case Report: A 60-year-old smoker male was presented with the complaints of non-healing ulcer (2x2 cm) at right anterolateral tongue since six months. Excision biopsy of tongue ulcer was reported as pT 0.8x0.8 cm, moderately differentiated squamous cell carcinoma. Wide local excision of tongue lesion with right modified neck dissection was done. Histopathology was reported as no residual primary tongue tumor seen, 1 out of 28 lymph nodes showed metastatic deposits of squamous cell carcinoma. Unexpectedly another one lymph node was positive of metastatic thyroid papillary carcinoma. Total thyroidectomy with central compartment neck dissection and left modified neck dissection was done. Histopathology was reported as pT 2x1 cm, papillary carcinoma right lobe of thyroid, 7 out of 32 lymph nodes showed metatstatic paillary carcinoma thyroid. Although exact cause of second malignancy is unknown but field cancerization, genetic predisposition, history of prior radiation or chemotherapy, improved survival can be attributed for increased incidence of second cancer. Conclusion: Double malignancies require multidisciplinary management approach.

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Cancer Survivorship—Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations

Cited by 300 publications

References 116 publications

Metachronous bile duct cancer nine years after resection of gallbladder cancer

Metachronous bile duct cancer nine years after resection of gallbladder cancer

Second cancers after fractionated radiotherapy: Stochastic population dynamics effects

Hypoxemia in minimally invasive esophagectomy for squamous cell carcinoma of lower esophagus

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