Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs

Gholamzad, Amir; Khakpour, Niloofar; Khosroshahi, Elaheh Mohandesi; Asadi, Saba; Koohpar, Zeinab Khazaei; Matinahmadi, Arash; Jebali, Ali; Rashidi, Mohsen; Hashemi, Mehrdad; Sadi, Farzaneh Hasani; Gholamzad, Mehrdad

doi:10.1016/j.prp.2024.155227

Cited by 4 publications

(2 citation statements)

References 183 publications

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“…Although the suppression of PDCD4 can have notable impacts on the behavior of cancer cells, there is still no conclusive evidence that it specifically targets and eliminates CSCs. Available data indicate that inhibiting PDCD4 may typically enhance tumor aggressiveness and resistance, potentially negatively impacting both CSCs and non-CSCs [ 66 ]. Further study specifically designed to examine the impact of PDCD4 inhibition on CSCs is necessary to offer a conclusive response.…”

Section: Dual Role Of Autophagy In the Maintenance Of Cancer Stem Cellmentioning

confidence: 99%

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

Rahman,

Apu,

Rakib-Uz-Zaman

et al. 2024

Cells

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Autophagy is a globally conserved cellular activity that plays a critical role in maintaining cellular homeostasis through the breakdown and recycling of cellular constituents. In recent years, there has been much emphasis given to its complex role in cancer stem cells (CSCs) and stem cell treatment. This study examines the molecular processes that support autophagy and how it is regulated in the context of CSCs and stem cell treatment. Although autophagy plays a dual role in the management of CSCs, affecting their removal as well as their maintenance, the intricate interaction between the several signaling channels that control cellular survival and death as part of the molecular mechanism of autophagy has not been well elucidated. Given that CSCs have a role in the development, progression, and resistance to treatment of tumors, it is imperative to comprehend their biological activities. CSCs are important for cancer biology because they also show a tissue regeneration model that helps with organoid regeneration. In other words, the manipulation of autophagy is a viable therapeutic approach in the treatment of cancer and stem cell therapy. Both synthetic and natural substances that target autophagy pathways have demonstrated promise in improving stem cell-based therapies and eliminating CSCs. Nevertheless, there are difficulties associated with the limitations of autophagy in CSC regulation, including resistance mechanisms and off-target effects. Thus, the regulation of autophagy offers a versatile strategy for focusing on CSCs and enhancing the results of stem cell therapy. Therefore, understanding the complex interactions between autophagy and CSC biology would be essential for creating therapeutic treatments that work in both regenerative medicine and cancer treatment.

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Section: Dual Role Of Autophagy In the Maintenance Of Cancer Stem Cellmentioning

confidence: 99%

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

Rahman,

Apu,

Rakib-Uz-Zaman

et al. 2024

Cells

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“…However, the notion of tumor stem cells was not consensual. A number of specific biomarkers of tumor stem cells (notably some biomarkers linked to the cellular surface state) were identified and thereafter abandoned [ 66 , 67 , 68 ]. Furthermore, as mentioned above, ionizing radiation does not impact the tumor stem cells pool preferentially while they induce cancer, which raises questions about the existence of tumor stem cells.…”

Section: From the 1940s To The 2000s Initiation Promotion And Progres...mentioning

confidence: 99%

When DNA Mutations Interplay with Cellular Proliferation: A Narrative History of Theories of Carcinogenesis

El Nachef,

Bouchet,

Bourguignon

et al. 2024

Cancers

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While cancer is one of the most documented diseases, how normal cells become cancerous is still debated. To address this question, in the first part of this review, we investigated the long succession of theories of carcinogenesis since antiquity. Initiated by Hippocrates, Aristotle, and Galen, the humoral theory interpreted cancer as an excess of acid, the black bile. The discovery of the circulation of blood by Harvey in 1628 destroyed the basis of the humoral theory but revived the spontaneous generation hypothesis which was also promoted by Aristotle. In 1859, the theory of microbes promoted by Pasteur demonstrated the irrelevance of this last theory and contributed to the emergence of the germ cancer theory, opposed to the cellular theory of cancer, in which cancer was supposed to be caused by microbes or transformed cells, respectively. These theories were progressively refined by the notions of initiation, promotion, and progression thanks to advances in mutagenesis and cellular proliferation. In the second part of this review, recent discoveries and paradigms in carcinogenesis, notably the role of the protein ATM, a major actor of the stress response involved in both mutagenesis and cellular proliferation, were discussed to better understand the current state of the art of carcinogenesis.

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Hyperthermia for Targeting Cancer and Cancer Stem Cells: Insights from Novel Cellular and Clinical Approaches

Smadja

2024

Stem Cell Rev and Rep

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Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs

Cited by 4 publications

References 183 publications

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

When DNA Mutations Interplay with Cellular Proliferation: A Narrative History of Theories of Carcinogenesis

Hyperthermia for Targeting Cancer and Cancer Stem Cells: Insights from Novel Cellular and Clinical Approaches

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