The advent of cancer stem cell (CSC) hypothesis has revolutionized the cancer biology community's thinking in explaining the notorious resistance of cancer to conventional chemo-and radiotherapies. The hypothesis states that the CSCs are a subpopulation within the tumor endowed with superior resistance and with the exclusive ability to self-renew, differentiate into diverse type of progeny cancer cells, and initiate tumor. Here, we review recent literature that seek out to explain such resistance of CSCs. Sig…
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