Cancer stem cells and strategies for targeted drug delivery

Cao, Jin; Bhatnagar, Shubhmita; Wang, Jiawei; Qi, Xueyong; Prabha, Swayam; Panyam, Jayanth

doi:10.1007/s13346-020-00863-9

Cited by 10 publications

(7 citation statements)

References 326 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on this model, the accumulation of mutations has resulted in carcinogenesis [ 61 , 63 ]. However, upon discovery of CSCs, a new concept of tumorigenesis was introduced, known as hierarchical model that CSCs are responsible for cancer development, maintaining and tumor seeding [ 64 ].…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

View full text Add to dashboard Cite

As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

show abstract

Section: Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…12 NDDSs can be further functionalized with CSC-specific targeting ligands to promote targeted drug delivery toward CSCs. 13 Moreover, NDDSs have unique advantages in encapsulating CSC-specific drugs and cytotoxic agents, realizing simultaneous killing of CSCs and bulk cancer cells. 14 Nonetheless, considering the complicated in vivo delivery processes and pathophysiological barriers, 15 killing CSCs is not an easy task for nanotherapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…Mounting studies have documented that multidrug-resistant Pglycoproteins (P-gps) and glutathione (GSH) were overexpressed in CSCs for pumping drugs out and detoxification, respectively. 13 To be potent in killing CSCs, nanotherapeutics need to take all these requirements into consideration. Around ten years ago, we summarized five basic features of efficient nanotherapeutics (the five features principle), which consist of long circulation, tumor accumulation, deep penetration, cellular internalization, and drug release.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the EPR effect associated with the pathophysiology of solid tumors, nanomaterial drug delivery systems (NDDSs) passively accumulate in tumor tissues, thereby alleviating severe side effects toward normal viscera . NDDSs can be further functionalized with CSC-specific targeting ligands to promote targeted drug delivery toward CSCs . Moreover, NDDSs have unique advantages in encapsulating CSC-specific drugs and cytotoxic agents, realizing simultaneous killing of CSCs and bulk cancer cells .…”

Section: Introductionmentioning

confidence: 99%

“…Drug-loading nanotherapeutics primarily rely on their payloads to exert toxicity on cytoplasmic or nuclear targets and kill CSCs. Mounting studies have documented that multidrug-resistant P-glycoproteins (P-gps) and glutathione (GSH) were overexpressed in CSCs for pumping drugs out and detoxification, respectively . To be potent in killing CSCs, nanotherapeutics need to take all these requirements into consideration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rational Design of Nanotherapeutics Based on the Five Features Principle for Potent Elimination of Cancer Stem Cells

et al. 2022

View full text Add to dashboard Cite

Metrics & MoreArticle Recommendations CONSPECTUS: Cancer stem cells (CSCs), also known as tumor initiating cells or tumor repopulating cells, which comprise only a small fraction of tumor, have received tremendous attention during the past two decades, as they are considered as the ringleader for initiation and progression of tumors, therapy resistance, metastasis, and recurrence in the clinic. Hence, eradicating CSCs is critical for successful cancer treatment. To that end, various CSC-targeting therapeutic agents have been pursued. However, these CSC-specific drugs are ineffective toward bulk cancer cells. Furthermore, these anti-CSC drugs not only eradicate CSCs but also affect conventional stem cells in normal organs or tissues. By virtue of the enhanced permeability and retention (EPR) effect, nanomaterial drug delivery systems (NDDSs) passively accumulate in tumor tissues, thereby alleviating severe side effects toward normal viscera. NDDSs can be further functionalized with CSC-specific binding molecules to promote targeted drug delivery toward CSCs. Moreover, NDDSs have unique advantages in encapsulating CSC-specific drugs and cytotoxic agents, realizing synchronized killing of CSCs and bulk cancer cells both temporally and spatially. For these reasons, leveraging nanotherapeutic strategies to target CSCs has gained tremendous attention recently. Some ten years ago, we summarized five basic features of efficient nanotherapeutics (the five features principle), which consist of long circulation, tumor accumulation, deep penetration, cellular internalization, and drug release. Based on this design rationale, we constructed several NDDSs, including nanogels with adaptive hydrophobicity, CSC-derived microparticles with tailored softness, and tumor exosome sheathed porous silicon biomimetic nanoparticles, for targeted drug delivery to tumor. To our astonishment, these NDDSs that possess the five basic features achieve decent drug delivery efficiency toward not only bulk tumor cells but more importantly CSCs. Consequently, such nanotherapeutics as-designed based on the five features principle are potent in eradicating CSCs, even with only cytotoxic drugs, for instance, doxorubicin. Furthermore, commercialized nanomedicines, such as Doxil and Abraxane, can be endowed with these five basic features by hyperbaric oxygen therapy and therefore achieve outstanding drug delivery efficiency, potent CSC elimination, and efficient cancer therapy. These studies suggest that intractable CSCs can be tackled with a material-based approach, highlight the critical role of the five features principle in designing effective nanotherapeutics, and pinpoint the significance of drug delivery efficiency in eliminating CSCs and bulk cancer cells.

show abstract

The effect of chemotherapy and radiotherapy on stem cells and wound healing. Current perspectives and challenges for cell-based therapies

Zawrzykraj,

Deptuła,

Kondej

et al. 2023

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Cancer stem cells and strategies for targeted drug delivery

Cited by 10 publications

References 326 publications

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Rational Design of Nanotherapeutics Based on the Five Features Principle for Potent Elimination of Cancer Stem Cells

The effect of chemotherapy and radiotherapy on stem cells and wound healing. Current perspectives and challenges for cell-based therapies

Contact Info

Product

Resources

About