Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

Gangemi, Rosaria; Paleari, Laura; Orengo, Anna Maria; Cesario, Alfredo; Chessa, Leonardo; Ferrini, Silvano; Russo, Patrizia

doi:10.2174/092986709788186147

Cited by 121 publications

(92 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7,8 The discovery of highly tumorigenic GSCs, which comprise a self-renewing subpopulation of GSCs, suggested that therapeutic approaches to effectively eradicate these cells may improve patient outcome. 9 Furthermore, present studies have demonstrated [10][11][12] that chemotherapy only destroys the most bulky cancer cells but cannot eradicate cancer stem cells (CSCs). The existence of CSCs leads to chemoresistance and tumor recurrence.…”

Section: Introductionmentioning

confidence: 98%

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

Wang

Xue

et al. 2017

IJN

View full text Add to dashboard Cite

Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood–brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p -aminophenyl-α-D-mannopyranoside could facilitate the transport of liposomes across the blood–brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the anti-tumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p -aminophenyl-α-D-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells.

show abstract

Section: Introductionmentioning

confidence: 98%

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

Wang

Xue

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…The survival of cancer stem cells leads to chemoresistance and tumor recurrence. 23,24 Therefore, eradicating cancer stem cells may represent an effective chemotherapeutic strategy and thereby overcome tumor resistance.…”

Section: Introductionmentioning

confidence: 99%

Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells

Wang¹,

Zhang²,

Liu³

et al. 2012

IJN

View full text Add to dashboard Cite

Background and methods: Curcumin has extraordinary anticancer properties but has limited use due to its insolubility in water and instability, which leads to low systemic bioavailability. We have developed a novel nanoparticulate formulation of curcumin encapsulated in stearic acid-g-chitosan oligosaccharide (CSO-SA) polymeric micelles to overcome these hurdles. Results:The synthesized CSO-SA copolymer was able to self-assemble to form nanoscale micelles in aqueous medium. The mean diameter of the curcumin-loaded CSO-SA micelles was 114.7 nm and their mean surface potential was 18.5 mV. Curcumin-loaded CSO-SA micelles showed excellent internalization ability that increased curcumin accumulation in cancer cells. Curcumin-loaded CSO-SA micelles also had potent antiproliferative effects on primary colorectal cancer cells in vitro, resulting in about 6-fold greater inhibition compared with cells treated with a solution containing an equivalent concentration of free curcumin. Intravenous administration of curcumin-loaded CSO-SA micelles marginally suppressed tumor growth but did not increase cytotoxicity to mice, as confirmed by no change in body weight. Most importantly, curcuminloaded CSO-SA micelles were effective for inhibiting subpopulations of CD44 + /CD24+ cells (putative colorectal cancer stem cell markers) both in vitro and in vivo. Conclusion:The present study identifies an effective and safe means of using curcumin-loaded CSO-SA micelles for cancer therapy.

show abstract

“…В соответствии с этими представлениями опухоль организована иерархично, как нормальная ткань, с небольшой субпопуляцией недифференциро-ванных клеток, имеющих уникальные биологические свойства, необходимые для инициации, поддержания и распространения опухоли [14,15]. CSC расположены в нише с мезенхимальными клетками, которые обес-печивают выживание CSC, регулируют их пролифе-рацию посредством секреции растворимых факторов [16].…”

Section: пути канцерогенеза толстой кишкиunclassified

Role of stem cells in large bowel carcinogenesis

Нефёдова¹,

Мальков²

2015

Onkol. koloproktol.

View full text Add to dashboard Cite

Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

Cited by 121 publications

References 0 publications

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells

Role of stem cells in large bowel carcinogenesis

Contact Info

Product

Resources

About