Cancer Stem Cell Marker Bmi‐1 Expression is Associated with Basal‐like Phenotype and Poor Survival in Breast Cancer

Wang, Yanyang; Zhe, Hong; Ding, Zhe; Gao, Ping; Zhang, Ningmei; Li, Guofu

doi:10.1007/s00268-012-1514-3

Cited by 50 publications

(37 citation statements)

References 46 publications

(53 reference statements)

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“…In the present study, Bmi-1 protein is observed to exist in the cytoplasm of gastric lesions, opposite to its nuclear expression pattern in breast (Yin et al, 2011; Wang et al, 2012), pancreatic (Yin et al, 2011), cervical , esophageal squamous , tongue squamous (Häyry et al, 2010), colon , bladder (Qin et al, 2009) and endometric (Engelsen et al, 2008) cancer cells. Another group also found cytoplasmic Bmi-1 expression in oropharyngeal squamous cell carcinoma (Huber et al, 2011).…”

Section: Discussioncontrasting

confidence: 56%

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

Lü

Sun²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Asian Pacific J Cancer Prev, 13, 3437-3441 IntroductionGastric carcinoma ranks as the world's second leading cause of cancer mortality behind lung cancer despite a sharp worldwide decline in both its incidence and mortality since the second half of the 20th century. It continues to be a major health problem because of the slow decrease in incidence in Asia and high mortality of diagnosed gastric carcinoma in West . Therefore, it is of much significance for the prevention, treatment and prognosis evaluation of gastric cancer to clarify its molecular mechanisms and find out a good biomarker to indicate its carcinogenesis and subsequent progression.Bmi-1(B-lymphoma Moloney murine leukemia virus insertion region-1) gene was first isolated as an proto-oncogene that cooperated with c-myc in generating lymphomas in a transgenic murine model. It is a transcriptional repressor belonging to the Polycombgroup (PcG) family of proteins which play an important role in axial patterning, hematopoiesis, regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription, the self-renewal and propagation of normal and cancer stem cells. Bmi-1 is localized in 10p11.23 with its 3434b

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Section: Discussioncontrasting

confidence: 56%

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

Lü

Sun²,

Li³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Bmi-1(B-cell specific Moloney murine leukemia virus insertion site 1),a transcriptional repressor of polycomb group of transcription factors, had been found to involve in self renewal of hematopoietic [5], neuronal [6] and mammary [7] stem cells, and has been implicated in the tumorigenesis of various malignancies, including leukemia [8], lymphomas [9], non-small cell lung cancer [10], breast cancer [11] and nasopharyngeal carcinoma [12]. Moreover, Bmi-1 was also found to play a key role in tumor metastasis [13].…”

Section: Introductionmentioning

confidence: 99%

Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

Chang

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Bmi-1 status is an independent prognostic factor, which also is associated with tumor histological grade and basal-like phenotype. The high proportions of positive Bmi-1 expression in BLBC may be related to the high aggressiveness behavior of this subtype of breast cancer (Wang et al, 2012). Apart from this study, Arnes et al have evaluated the relationship between Bmi-1 expression and basal-like phenotype.…”

Section: Discussionmentioning

confidence: 95%

Clinical Significance of Basal-like Breast Cancer in Chinese Women in Heilongjiang Province

Liu

Jiang²,

Xin³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE-in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.

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Cancer Stem Cell Marker Bmi‐1 Expression is Associated with Basal‐like Phenotype and Poor Survival in Breast Cancer

Cited by 50 publications

References 46 publications

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

Clinical Significance of Basal-like Breast Cancer in Chinese Women in Heilongjiang Province

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