Abstract:Glioblastoma (GBM) remains among the deadliest of human malignancies. The emergence of the cancer stem cell (CSC) phenotype represents a major challenge to disease management and durable treatment response. The extrinsic, environmental, and lifestyle factors that result in CSC enrichment are not well understood. The CSC state endows cells with a fluid metabolic profile, enabling the utilization of multiple nutrient sources. Therefore, to test the impact of diet on CSC enrichment, we evaluated disease progressi… Show more
“…CSE-deficiency in these cells therefore imparts some advantages to the cancer cells in regards to increased proliferative activity. H2S deficiency has shown to increase proliferation and drug resistance in both cancerous and non-cancerous cells, such as glioblastoma and smooth muscles cells106,107 . A likely mechanism for these observations is the increase in ALDH expression in CSE deficient tissues, as evidenced by the increase in ADLH seen in CSE-KO mouse liver.…”
Title of Thesis Titre de la thèseThe interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth Name of Candidate Nom du candidat Read, Ethan
“…CSE-deficiency in these cells therefore imparts some advantages to the cancer cells in regards to increased proliferative activity. H2S deficiency has shown to increase proliferation and drug resistance in both cancerous and non-cancerous cells, such as glioblastoma and smooth muscles cells106,107 . A likely mechanism for these observations is the increase in ALDH expression in CSE deficient tissues, as evidenced by the increase in ADLH seen in CSE-KO mouse liver.…”
Title of Thesis Titre de la thèseThe interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth Name of Candidate Nom du candidat Read, Ethan
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