Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007

Jung, Kyu Won; Kong, Hyun Joo; Won, Young Joo; Boo, You Kyung; Shin, Hai Rim; Park, Sohee; Lee, Jin Soo

doi:10.3346/jkms.2010.25.8.1113

Cited by 211 publications

(167 citation statements)

References 12 publications

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“…Other population data such as death certificate also are used as a supplementary data for covering the cancer patients who did not use medical service. This national cancer registry is used as an official source of national cancer data in Korea (Shin et al, 2005;Jung et al, 2010), and was also included in the Cancer Incidence in Five Continents Volume IX (Curado et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Cancer Incidence Rates between the National Cancer Registry and Insurance Claims Data in Korea

Seo¹,

Oh²,

Yoon³

2012

Asian Pacific Journal of Cancer Prevention

109

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Although much health services research has been conducted using national health insurance claims data in Korea, the validity of this method has not been ascertained. The objective of this study was to validate the use of claims data for health services research by comparing incidence rate of cancers found using insurance claims data against rates of the national cancer registry of Korea. An algorithm to estimate incidence rates using claims data was developed and applied. The claims data from 2005-2008 were acquired and the patients admitted to hospitals due to cancer in 2008 without admission to hospital from 2005-2007 by the same diagnosis code were regarded as incident cases. The acquired results were compared with the values from the National Cancer Registry of Korea. The incidence rate of all cancers found using claims data was 363.1 per 100,000 people, which is very similar to the 361.9 per 100,000 rate of the national cancer registry. Also the age-, gender-and disease-specific rates between the two data sources were similar. Therefore, national health insurance claims data may be a worthwhile resource for health services research if appropriate algorithms are applied, especially considering the cost effectiveness of this method.

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Section: Introductionmentioning

confidence: 99%

A Comparison of the Cancer Incidence Rates between the National Cancer Registry and Insurance Claims Data in Korea

Seo¹,

Oh²,

Yoon³

2012

Asian Pacific Journal of Cancer Prevention

109

View full text Add to dashboard Cite

show abstract

“…Although surgery, chemotherapy, and radiotherapy have been standard cancer treatment options for many years, these anti-cancer therapies can only offer modest benefits for cancer patients with metastases, acquired chemoresistance, and toxicity [28][29][30] . Consequently, cancer prevention using non-toxic chemical entities, commonly termed "chemoprevention," is a more realistic and fundamental strategy for the management of this disease.…”

Section: Discussionmentioning

confidence: 99%

α-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway

Shan

Cui

et al. 2014

Acta Pharmacol Sin

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Aim: To investigate the anti-tumor effects of α-mangostin, a major xanthone identified in the pericarp of mangosteen (Garcinia mangostana Linn), against human gastric adenocarcinoma cells in vitro, and the mechanisms of the effects. Methods: Human gastric adenocarcinoma cell lines BGC-823 and SGC-7901 were treated with α-mangostin. The cell viability was measured with MTT assay, and cell apoptosis was examined using flow cytometry and TUNEL assay. The expression of the relevant proteins was detected using Western blot. Results: Treatment with α-mangostin (3-10 μg/mL) inhibited the viability of both BGC-823 and SGC-7901 cells in dose-and timemanners. Furthermore, α-mangostin (7 μg/mL) time-dependently increased the apoptosis index of the cancer cells, reduced the mitochondrial membrane potential of the cancer cells, and significantly increased the release of cytochrome c and AIF into cytoplasm. Moreover, the α-mangostin treatment markedly suppressed the constitutive Stat3 protein activation, and Stat3-regulated Bcl-xL and Mcl-1 protein levels in the cancer cells. Conclusion: The anti-tumor effects of α-mangostin against human gastric adenocarcinoma cells in vitro can be partly attributed to blockade of Stat3 signaling pathway.

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“…In Korea, the situation is similar to that of the United States. In 2007, thyroid cancer became the most common type of cancer in females (73.5 individuals per 100,000) (3). Improvements in diagnostic techniques are regarded as the main reason for this sharp increase.…”

Section: Introductionmentioning

confidence: 99%

Association of CFTR gene polymorphisms with papillary thyroid cancer

Yoon

et al. 2011

Oncology Letters

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Abstract. The incidence of thyroid cancer has been on the increase in a number of countries, and certain genetic factors associated with the increased incidence of the papillary thyroid cancer (PTC) have been identified. However, little is known about the effect of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, expressed in the thyroid. We hypothesized and investigated that CFTR single nucleotide polymorphisms (SNPs) may be associated with the risk and/or progression of PTC. A total of 105 PTC patients, confirmed by pathological tests, and 323 controls, without any thyroidal disease, were recruited. One promoter SNP (rs4148682) and one coding SNP (rs213950, Val470Met) in the CFTR gene were analyzed, using direct sequencing. The PTC patients were sub-grouped and compared by their clinical and pathological characteristics of PTC. The results showed that the association between SNPs in the CFTR gene and the development of PTC was statistically insignificant. However, in the clinical and pathological features, rs4148682 was found to be correlated with multifocal tumors, location and cervical node metastasis of PTC. rs231950 was also correlated with multifocal tumors, location and nodal metastasis of PTC. The G allele of rs213950 was correlated with increased risk of multifocal tumors and bilateral lobe location. However, in cervical lymph node metastasis, the A allele of rs213950 was found to reflect high risk. Our study suggests that the CFTR gene polymorphisms studied may not be associated with the development of PTC, but that rs4148682 and rs213950 may be associated with clinical features and prognosis, such as multifocality, location of cancer and cervical lymph node metastasis of PTC.

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Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007

Cited by 211 publications

References 12 publications

A Comparison of the Cancer Incidence Rates between the National Cancer Registry and Insurance Claims Data in Korea

A Comparison of the Cancer Incidence Rates between the National Cancer Registry and Insurance Claims Data in Korea

α-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway

Association of CFTR gene polymorphisms with papillary thyroid cancer

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