Cancer statistics in China, 2015

Abstract

With increasing incidence and mortality, cancer is the leading cause of death in China and is a major public health problem. Because of China's massive population (1.37 billion), previous national incidence and mortality estimates have been limited to small samples of the population using data from the 1990s or based on a specific year. With high-quality data from an additional number of population-based registries now available through the National Central Cancer Registry of China, the authors analyzed data from 72 local, population-based cancer registries (2009-2011), representing 6.5% of the population, to estimate the number of new cases and cancer deaths for 2015. Data from 22 registries were used for trend analyses (2000-2011). The results indicated that an estimated 4292,000 new cancer cases and 2814,000 cancer deaths would occur in China in 2015, with lung cancer being the most common incident cancer and the leading cause of cancer death. Stomach, esophageal, and liver cancers were also commonly diagnosed and were identified as leading causes of cancer death. Residents of rural areas had significantly higher age-standardized (Segi population) incidence and mortality rates for all cancers combined than urban residents (213.6 per 100,000 vs 191.5 per 100,000 for incidence; 149.0 per 100,000 vs 109.5 per 100,000 for mortality, respectively). For all cancers combined, the incidence rates were stable during 2000 through 2011 for males (+0.2% per year; P = .1), whereas they increased significantly (+2.2% per year; P < .05) among females. In contrast, the mortality rates since 2006 have decreased significantly for both males (-1.4% per year; P < .05) and females (-1.1% per year; P < .05). Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.

Phase Ib/II study of safety and efficacy of low‐dose decitabine‐primed chemoimmunotherapy in patients with drug‐resistant relapsed/refractory alimentary tract cancer

“…2ECOG performance‐status scores range from 0 to 5, with 0 indicating no symptoms and higher scores indicating increasing symptoms. 3Chemotherapy regimen: PT, paclitaxel and cisplatin; IP, irinotecan and cisplatin; FOLFOX, oxaliplatin, leucovorin and fluorouracil; FOLFIRI, irinotecan, leucovorin and fluorouracil.…”

“…Alimentary tract (AT) cancer is one of the leading public health problems worldwide,1 particularly in Asia, where its increasing incidence and mortality has led to a major public health burden 2, 3. Various organ cancers are categorized under AT malignancies, but the three most common are esophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC), which also account for three of the top five most frequently diagnosed and lethal cancers in China 3.…”

“…Various organ cancers are categorized under AT malignancies, but the three most common are esophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC), which also account for three of the top five most frequently diagnosed and lethal cancers in China 3. Chemotherapy is the main therapeutic option for AT cancer patients, but the prognosis has not improved significantly in recent years due to intrinsic or acquired drug resistance 4, 5, 6, 7…”

Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β‐catenin signaling pathway in breast cancer

“…In China, there was an estimated 0.27 million breast cancer cases which leaded to 0.07 million deaths in 2015 2. Breast cancer patients mainly died of cancer metastasis; however, the mechanism of breast cancer cells proliferation and metastasis was not clear, which needed further study.…”

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

“…Gastric cancer is the second most common cancer and the second leading cause of cancer death in China 1. The environmental risk factors for gastric cancer include high‐salt diet, smoking, and infectious agents 2.…”