Cancer Statistics, 1971

Silverberg, B S Edwin; Holleb, Arthur I.

doi:10.3322/canjclin.21.1.13

Cited by 126 publications

(123 citation statements)

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“…This may be because of the change in the social life-style of women in most part of the developed and developing countries which is now similar to that of men [138].…”

Section: Discussionmentioning

confidence: 99%

“…This may explain the reason why all the studies in this meta-analysis reported on the cancer of the anterior two third of the tongue (Table 1) Over 6,000 new cases of oral cavity carcinomas are diagnosed every year. It accounted for 4 -5% of all malignancies in men and 2% of all malignancies in women [74,138], and accounted for 3% of all cancer deaths in men and 1% of all cancer deaths in women [138]. The morbidity from the disease usually results from the impairment of the inherent physiologic functions that usually take place in the head and neck region.…”

Section: Discussionmentioning

confidence: 99%

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A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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“…This may be because of the change in the social life-style of women in most part of the developed and developing countries which is now similar to that of men [138].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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“…Patients with adenocarcinoma of the pancreas have worse survival than patients with any other gastrointestinal malignancy (Silverberg and Lubera, 1988). The poor prognosis is principally due to difficulty in diagnosing pancreatic adenocarcinoma at a localised resectable stage and the propensity towards early tumour metastasis to regional lymph nodes and the liver.…”

mentioning

confidence: 99%

Clinical significance of midkine expression in pancreatic head carcinoma

et al. 2007

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Midkine (MK) is a heparin-binding growth factor and a product of a retinoic acid-responsive gene. Midkine is overexpressed in many carcinomas and thought to play an important role in carcinogenesis. However, no studies have been focussed on the role of MK in pancreatic carcinoma. This study sought to evaluate the clinical significance of MK expression in pancreatic head carcinoma, including the relationship between immunohistochemical expression and clinicopathologic factors such as prognosis. Immunohistochemical expression of MK and CD34 was evaluated in pancreatic head carcinoma specimens from 75 patients who underwent surgical resection. Midkine was expressed in 53.3% of patients. Midkine expression was significantly correlated with venous invasion, microvessel density, and liver metastasis (P ¼ 0.0063, 0.0025, and 0.0153, respectively). The 5-year survival rate was significantly lower for patients positive for MK vs patients negative for MK (P ¼ 0.0073). Multivariate analysis revealed that MK expression was an independent prognostic factor (P ¼ 0.0033). This is the first report of an association between MK expression and pancreatic head carcinoma. Midkine may play an important role in the progression of pancreatic head carcinoma, and evaluation of MK expression is useful for predicting malignant properties of pancreatic head carcinoma.

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“…1 On the one hand, more efforts will have to be made to detect prostate carcinoma at an early stage to lower the mortality since extended disease cannot be cured. On the other, increased prostate awareness leaves us with a large number of patients who have an elevated prostatespeci®c antigen (PSA) but have no abnormalities on digital rectal examination (DRE) and normal transrectal ultrasound (TRUS).…”

Section: Introductionmentioning

confidence: 99%

Correlation of transrectal ultrasound, computer analysis of transrectal ultrasound and histopathology of radical prostatectomy specimen

Beerlage

Aarnink

Ruijter

et al. 2001

Prostate Cancer Prostatic Dis

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A system for computerised analysis of ultrasonographic prostate images (AUDEX Automated Urologic Diagnostic EXpert system) for the detection of prostate carcinoma was developed. The ultimate goal is to develop a system that is reliable and non-observer dependent. Results of an earlier study with a small group were encouraging and this study describes the results of the computerised analysis in a larger group. Sixty-two patients who were scheduled to undergo a radical prostatectomy were prospectively analysed. The radical prostatectomy specimens were step-sectioned in the transverse plane, corresponding to the ultrasound pictures. Malignant regions identi®ed by each study were quanti®ed and compared by computer calculation. No correlation was observed between ultrasound analysis and pathology result. For the AUDEX analysis an overall sensitivity of 85% and a speci®city of 18% with only a diagnostic accuracy of 57% was noticed when presence or absence of malignancy was evaluated by octant (total 496). When applying a cut-off value of 0.5 ml the numbers were 71%, 33% and 55%, respectively. Correlation was signi®cantly better for the ventral octants. In this study the earlier results of our AUDEX system could not be con®rmed. Although sensitivity was good, speci®city and especially diagnostic accuracy were lower than expected. We have to conclude that the current settings are inappropriate for routine clinical use. Prostate Cancer and Prostatic Diseases (2001) 4, 56±62.

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Cancer Statistics, 1971

Cited by 126 publications

References 1 publication

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

Clinical significance of midkine expression in pancreatic head carcinoma

Correlation of transrectal ultrasound, computer analysis of transrectal ultrasound and histopathology of radical prostatectomy specimen

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