Cancer-specific survival and metastasis in pancreatic mucinous cystadenocarcinoma: A SEER-based cohort study

Abstract

AimsThis study aimed to investigate the prognostic value of clinical features for cancer-specific survival (CSS) and metastasis in patients with pancreatic mucinous cystadenocarcinoma (MCAC). We further constructed and validated an effective nomogram to predict CSS.MethodsWe screened patients diagnosed with pancreatic MCAC from Surveillance Epidemiology and End Results (SEER) database. Kaplan-Meier curves were used to determine the CSS time. Univariate and multivariate Cox and logistic regression analyses were conducted to identify the prognostic factors for CSS and metastasis. The nomogram was constructed to predict the prognosis of pancreatic MCAC based on the results from the multivariate analysis. We used the concordance index (C-index), the area under the curve (AUC), and the calibration plots to determine the predictive accuracy and discriminability of the nomogram.ResultsMultivariate Cox analysis revealed that age, primary site, grade, and radiotherapy were independent prognostic factors associated with CSS. Multivariate logistic regression analysis revealed that surgery and grade were independent risk factors associated with metastasis. The independent risk factors were included to construct a prognosis prediction model for predicting CSS in patients with pancreatic MCAC. The concordance index (C-index), receiver operating characteristic (ROC) curves, and calibration plots of the training cohort and the validation cohort showed that the nomogram had an acceptable predictive performance.ConclusionWe established a nomogram that could determine the 3- and 5-year CSS, which could evaluate individual clinical outcomes and provide individualized clinical decisions.

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“…In our study, The CSS was found to be signi cantly lower in patients aged 70 years and above compared to younger patients. Similar results can be seen in previous studies [24,25]. Elderly patients often have poor physical tness, cannot tolerate treatment, and suffer from other conditions.…”

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“…In summary, effective management of pancreatic malignant neoplasm plays a vital role in improving patient survival, reducing recurrence, and enhancing overall quality of life. [4], [5], [6]…”

“…For more detailed information, it is advisable to consult with a healthcare professional. [4] Chymotrypsin-like elastase family member 3B (CELA3B) functions as an enzyme in the pancreas associated with digestive functions. Its expression is exclusive to the pancreas, and studies have explored its potential diagnostic value in distinguishing distinguishing pancreatic from non-pancreatic cancers and within differentiating acinar cell carcinoma from adenocarcinoma of the ducts.…”

“…In summary, effective management of pancreatic malignant neoplasm plays a vital role in improving patient survival, reducing recurrence, and enhancing overall quality of life. [4], [5], [6] 1.1. Associated human genes/Proteins Mutations in the KRAS gene are some of the most common genetic changes.…”