Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

Kachuri, Linda; Harris, Marianne; MacLeod, Jill; Tjepkema, Michael; Peters, Paul A.; Demers, Paul A.

doi:10.1186/s12885-017-3346-x

Cited by 80 publications

(77 citation statements)

References 57 publications

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“…In a previous large Canadian cohort study linked with cancer registry records, hazard ratios of the agriculture sector for lung, colon, bladder, kidney and liver cancers were found to be significantly lower than for other occupational workers . The risk reduction observed for kidney, bladder and colon cancers may be because of the working conditions of agricultural workers that involve high physical activity, a recognized modifiable risk factor for such cancers .…”

Section: Discussionmentioning

confidence: 89%

“…Such workers deal with many potential hazards that include pesticides, chemical and biological agents, and the operation of heavy equipment. However, a lower prevalence of smoking plus high occupational activity has been reported for this sector and this may have influenced the low mortality and morbidity rates from cancers observed among farmers …”

Section: Discussionmentioning

confidence: 99%

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Risk of cancer and longest‐held occupations in Japanese workers: A multicenter hospital‐based case‐control study

Kaneko

Zaitsu

Sato³

et al. 2019

Cancer Medicine

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Objectives Little is known about the risk of developing various cancers according to occupation and occupational physical activity. Methods Using nationwide clinical inpatient data (1984‐2017) in Japan, we undertook a multicentered, matched case‐control study with regard to the risk of developing various cancers according to occupation and using patients admitted with fractures as controls. Using standardized national occupation and industrial classifications, we first identified the longest‐held job for each patient. Using sales workers as the reference group, odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression, adjusted for age, admission period, and the admitting hospital, with smoking, alcohol consumption, and lifestyle diseases as covariates. The risk of high and low occupational physical activity was also estimated. Results Across all occupations, a reduced risk for all common cancers among males was observed among those occupations associated with high physical activities, such as agriculture. People in these occupations tended to show a lower risk for most cancers, including, for example, prostate cancer (OR 0.58, 95% CI 0.45‐0.75) and lung cancer (OR 0.63, 95% CI 0.51‐0.76). For females, the breast cancer risk was low in women engaged in agriculture (OR 0.58, 95% CI 0.45‐0.75) and in those occupations with high levels of occupational physical activity (OR 0.58, 95% CI 0.52‐0.66). Conclusions This study revealed differences in cancer risk among diverse occupations in Japan. Specifically, those occupations associated with high levels of physical activity may be associated with a decreased risk of cancer.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Risk of cancer and longest‐held occupations in Japanese workers: A multicenter hospital‐based case‐control study

Kaneko

Zaitsu

Sato³

et al. 2019

Cancer Medicine

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“…Persistence in the environment, ability to concentrate up the food chain, continued detection in breast milk, and ability to be stored in the adipose tissue of animals and humans are some of the reasons stated. 11,12 More studies need to be done in developing country setting for building evidence regarding this association. No significant association was observed between cancer and source of drinking water supply among residents.…”

Section: Discussionmentioning

confidence: 99%

Cancer burden and alarm signals: a community based study from Kerala, India

et al. 2020

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Background: Cancer is emerging as a major public health concern in many countries including India. Kerala state has the highest burden of cancer in the country. Objective of this study was to estimate the prevalence of diagnosed cancers, warning signs and selected risk factors of cancer in Kadapra Panchayath of Pathanamthitta district, Kerala.Methods: A total of 16,391 population was covered by door to door survey using a structured questionnaire. The questionnaire collected information on the sociodemographic variables of the residents, source of water supply, warning signs of cancer and details of diagnosed cancer cases.Results: The mean age of the population was 40.9+21 years. The prevalence of diagnosed cases of cancer in our study population was 776/100,000 population. Breast cancer was the most common cancer (43.5%) identified in the population. The prevalence of any warning sign among the study population was 220/100,000 population. Breast lump was the common warning sign identified. Increasing age and female gender were the factors found to be significantly associated with cancer.Conclusions: As prevalence of cancer was found to be high in this population, an active community based screening along with teaching self-breast examination to the women in the community are required. Improving community awareness could help in early diagnosis, treatment and prevention. Soil and water testing for carcinogens is recommended.

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“…Despite methodological issues in some studies, the exposure to potential or confirmed carcinogens such as herbicides and pesticides commonly used by agricultural workers have been pointed out as key determinants of the cancer risk observed in agricultural populations. Some studies found a different pattern of risk according to sex [86] or even in female spouses of pesticide applicators [87]. Glyphosate is the most commonly used herbicide in the world and recent meta-analysis points out a marginally significant positive association with MM [88].…”

Section: Occupational MMmentioning

confidence: 99%

Epidemiology of Multiple Myeloma

Ríos-Tamayo¹,

Rodríguez²,

Chan³

et al. 2019

Update on Multiple Myeloma

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Multiple myeloma is a heterogeneous hematological malignancy in which epidemiology plays an increasingly important role. In recent years, an unprecedented intensive research, including both clinical and molecular epidemiology, has deepened the knowledge about its pathogenesis, risk factors, and prognostic factors, leading also to the approval of new drugs. Although the etiology remains largely unknown, among the confirmed risk factors, only obesity and the exposure to certain carcinogens are potentially preventable. Familial myeloma and occupational myeloma are topics of great interest. Most population-based cancer registries show a stable incidence or only a slight trend to increase. The diagnostic delay should be avoided as much as possible. Mortality rates, including early mortality, are progressively decreasing, although infection remains the leading cause of mortality. The outcome in terms of overall survival and health-related quality of life has remarkably improved, joining the group of potentially curable malignancies. Nowadays the clinical scenario is challenging. Clinical and epidemiological variables of interest should be standardized in clinical records. Patients should be included in a population-based registry network. The clinical coordination of a multidisciplinary team in a specialized unit is needed in order to maximize the outcome of every patient.

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Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

Cited by 80 publications

References 57 publications

Risk of cancer and longest‐held occupations in Japanese workers: A multicenter hospital‐based case‐control study

Risk of cancer and longest‐held occupations in Japanese workers: A multicenter hospital‐based case‐control study

Cancer burden and alarm signals: a community based study from Kerala, India

Epidemiology of Multiple Myeloma

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